LEADER 01861nam 2200373 n 450 001 996392250903316 005 20200824121629.0 035 $a(CKB)4940000000107559 035 $a(EEBO)2240960801 035 $a(UnM)99861854e 035 $a(UnM)99861854 035 $a(EXLCZ)994940000000107559 100 $a19920723d1647 uh | 101 0 $aeng 135 $aurbn||||a|bb| 200 13$aAn ordinance of the Lords and Commons assembled in Parliament$b[electronic resource] $eConcerning the growth and spreading of errors, heresies, and blasphemies. Setting a part a day of publike humiliation, to seeke Gods assistance for the suppressing and preventing the same. Die Jovis 4. Febr. 1646. Ordered by the Lords assembled in Parliament, that this ordinance shall be printed and published; and that the sheriffs, or their under sheriffs, shall take care to carry downe the said ordinances; and that they be delivered unto the severall ministers of every parish church and chappell within the counties of the kingdome of England and dominion of Wales; who are to take notice of the said ordinance accordingly. Jo. Brown. Cler. Parliamentorum 210 $aLondon $cPrinted for John Wright at the Kings Head in the old Bayley.$d1646. [i.e. 1647] 215 $a[2], 5, [1] p 300 $aReproduction of the original in the British Library. 330 $aeebo-0018 606 $aHeresy$vEarly works to 1800 606 $aBlasphemy$vEarly works to 1800 607 $aGreat Britain$xChurch history$y17th century 615 0$aHeresy 615 0$aBlasphemy 712 02$aEngland and Wales.$bParliament. 801 0$bCu-RivES 801 1$bCu-RivES 801 2$bCStRLIN 801 2$bWaOLN 906 $aBOOK 912 $a996392250903316 996 $aAn ordinance of the Lords and Commons assembled in Parliament$92298865 997 $aUNISA LEADER 01050nam 2200313 a 450 001 996247860803316 005 20221028200051.0 035 $a(dli)HEB01383 035 $a(CKB)1000000000397582 035 $a(EXLCZ)991000000000397582 100 $a20020522d1958 uy 0 101 0 $aeng 135 $aurmnummmmuuuu 200 10$aMachiavelli & the Renaissance$b[electronic resource] /$fFederico Chabod ; translated from the Italian by David Moore ; with an introduction by A.P. D'Entre?ves 210 $aLondon $cBowes & Bowes$d1958 215 $axviii, 258 p. ;$d22 cm 320 $aIncludes bibliographical references (p. 201-247) and index. 410 0$aACLS Humanities E-Book. 517 3 $aMachiavelli and the Renaissance 606 $aRenaissance$zItaly 615 0$aRenaissance 700 $aChabod$b Federico$0138093 712 02$aAmerican Council of Learned Societies. 801 0$bMiU 801 1$bMiU 906 $aBOOK 912 $a996247860803316 996 $aMachiavelli & the Renaissance$92950826 997 $aUNISA LEADER 06711nam 22007575 450 001 9910298642403321 005 20251117075859.0 010 $a3-662-43787-2 024 7 $a10.1007/978-3-662-43787-2 035 $a(CKB)3710000000268435 035 $a(EBL)1968099 035 $a(OCoLC)896848767 035 $a(SSID)ssj0001372314 035 $a(PQKBManifestationID)11734757 035 $a(PQKBTitleCode)TC0001372314 035 $a(PQKBWorkID)11304081 035 $a(PQKB)10251010 035 $a(MiAaPQ)EBC1968099 035 $a(DE-He213)978-3-662-43787-2 035 $a(PPN)182099415 035 $a(EXLCZ)993710000000268435 100 $a20141024d2014 u| 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 14$aThe Blood Brain Barrier (BBB) /$fedited by Gert Fricker, Melanie Ott, Anne Mahringer 205 $a1st ed. 2014. 210 1$aBerlin, Heidelberg :$cSpringer Berlin Heidelberg :$cImprint: Springer,$d2014. 215 $a1 online resource (169 p.) 225 1 $aTopics in Medicinal Chemistry,$x1862-2461 ;$v10 300 $aDescription based upon print version of record. 311 08$a3-662-43786-4 320 $aIncludes bibliographical references and index. 327 $a""Preface""; ""Contents""; ""The Blood-Brain Barrier: An Introduction to Its Structure and Function""; ""1 The BBB: A Historical Perspective""; ""2 Evolutionary Development of a BBB""; ""3 Anatomic Principles of the BBB""; ""4 Pericytes""; ""5 Astrocyte: Endothelium Interactions""; ""6 Neurons""; ""7 Basal Membrane""; ""8 Junctional Complexes at the BBB""; ""9 Transport Proteins at the BBB""; ""10 Cytotic Processes at the BBB""; ""11 Outlook""; ""References""; ""In Vivo Approaches to Assessing the Blood-Brain Barrier""; ""1 Introduction"" 327 $a""2 Pharmacokinetic Principles of Blood-Brain Barrier Transport""""3 Methods""; ""3.1 Brain Uptake Index (Carotid Artery Single Injection Technique)""; ""3.2 The i.v. Injection Technique""; ""3.3 In Situ Brain Perfusion""; ""3.4 Brain Efflux Index""; ""3.5 Percentage of the Injected Dose""; ""3.6 Microdialysis""; ""3.7 CSF Sampling""; ""3.8 Positron Emission Tomography""; ""3.9 Combinatorial Mapping of Kp,uu,brain""; ""4 Conclusions""; ""References""; ""ABC Transporters at the Blood-Brain Barrier""; ""1 Introduction""; ""2 ABC Transporters at the Blood-Brain Barrier"" 327 $a""2.1 Assessing ABC Transporter Activity/Expression""""3 Modulation of ABC Transporter Expression and Activity""; ""3.1 Altered Transporter Expression""; ""3.1.1 Response to Xenobiotics""; ""3.1.2 Response to Disease""; ""3.2 Altered Transporter Activity Through Signaling""; ""3.2.1 Regulation of P-Glycoprotein Activity Through Sphingolipid Signaling""; ""3.2.2 Regulation of P-Glycoprotein Activity Through VEGF Signaling""; ""3.2.3 Regulation of BCRP Activity Through Estrogen Signaling""; ""3.2.4 Mechanisms Underlying Decreased Transporter Activity""; ""4 Perspectives""; ""References"" 327 $a""Nanoparticles as Blood-Brain Barrier Permeable CNS Targeted Drug Delivery Systems""""1 Introduction""; ""1.1 Blood-Brain Barrier""; ""1.2 Blood-Cerebrospinal Fluid Barrier (BCB) and CSF-Brain Barrier""; ""1.3 CNS Drug Delivery Strategies""; ""1.4 Nanomedicine Exploitation""; ""1.5 Nanomedicines for BBB Crossing: General Considerations""; ""2 BBB Crossing Nanocarriers""; ""2.1 Poly(n-butylcyanoacrylate) (PBCA) NPs""; ""2.2 Methoxypoly(ethylene glycol)-polylactide or Poly(lactide-co-glycolide) (mPEG-PLA/PLGA) NPs""; ""2.3 Liposomes""; ""2.4 Inorganic Nanosystems""; ""3 Conclusions"" 327 $a""References""""Blood-Brain Barrier and Stroke""; ""1 Introduction""; ""2 Injury to BBB Cell Components After Stroke""; ""2.1 Endothelial Cells""; ""2.2 Pericytes""; ""2.3 Astrocytes""; ""3 Basement Membrane, Extracellular Matrix, and Stroke""; ""4 Systemic and Local Inflammation and BBB Permeability After Stroke""; ""4.1 Chemokines, Adhesion Molecules, and Leukocyte Trafficking""; ""4.2 Parenchymal Brain Cells""; ""4.3 Perivascular Inflammatory Cells""; ""5 Post-ischemic Vascular and Brain Repair""; ""6 BBB Responses to Stroke in the Perinatal Period"" 327 $a""7 BBB Integrity, Angiogenesis, and Brain Repair After Stroke During the Perinatal Period"" 330 $aMedicinal chemistry is both science and art. The science of medicinal chemistry offers mankind one of its best hopes for improving the quality of life. The art of medicinal chemistry continues to challenge its practitioners with the need for both intuition and experience to discover new drugs. Hence sharing the experience of drug research is uniquely beneficial to the field of medicinal chemistry. Drug research requires interdisciplinary team-work at the interface between chemistry, biology and medicine. Therefore, the topic-related series Topics in Medicinal Chemistry covers all relevant aspects of drug research, e.g. pathobiochemistry of diseases, identification and validation of (emerging) drug targets, structural biology, drugability of targets, drug design approaches, chemogenomics, synthetic chemistry including combinatorial methods, bioorganic chemistry, natural compounds, high-throughput screening, pharmacological in vitro and in vivo investigations, drug-receptor interactions on the molecular level, structure-activity relationships, drug absorption, distribution, metabolism, elimination, toxicology and pharmacogenomics. 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