LEADER 00947cam0-2200325---450- 001 990008556420403321 005 20071217083253.0 010 $a88-243-1398-1 020 $aIT$b2002-7603 035 $a000855642 035 $aFED01000855642 035 $a(Aleph)000855642FED01 035 $a000855642 100 $a20070928d2001----km-y0itay50------ba 101 0 $aita 102 $aIT 105 $ay-------001yy 200 1 $a<>prova indiziaria e il giusto processo$el'art. 192 C.P.P. e la Legge 63/2001$fVincenzo Russo, Antonio Abet 210 $aNapoli$cJovene$dc2001 215 $aVII, 246 p.$d24 cm 676 $a345.45064$v21$zita 700 1$aRusso,$bVincenzo$0191358 701 1$aAbet,$bAntonio$0303833 801 0$aIT$bUNINA$gRICA$2UNIMARC 901 $aBK 912 $a990008556420403321 952 $aXIII D 167$b42933*$fFGBC 959 $aFGBC 996 $aProva indiziaria e il giusto processo$9709107 997 $aUNINA LEADER 05318nam 2200649Ia 450 001 996218619503316 005 20230721030648.0 010 $a1-281-32024-2 010 $a9786611320249 010 $a0-470-98874-6 010 $a0-470-99422-3 035 $a(CKB)1000000000401063 035 $a(EBL)350928 035 $a(OCoLC)476169700 035 $a(SSID)ssj0000102932 035 $a(PQKBManifestationID)11108581 035 $a(PQKBTitleCode)TC0000102932 035 $a(PQKBWorkID)10061034 035 $a(PQKB)10096807 035 $a(MiAaPQ)EBC350928 035 $a(EXLCZ)991000000000401063 100 $a20060519d2007 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aAnalysis of drug impurities$b[electronic resource] /$fedited by Richard J. Smith and Michael L. Webb 210 $aOxford ;$aAmes, Iowa $cBlackwell$d2007 215 $a1 online resource (290 p.) 225 1 $aAnalytical chemistry series 300 $aDescription based upon print version of record. 311 $a1-4051-3358-9 320 $aIncludes bibliographical references and index. 327 $aAnalysis of Drug Impurities; Contents; Preface; List of contributors; 1 Organic impurities in drug substance: origin, control, and measurement; 1.1 Introduction; 1.2 Origin of impurities; 1.2.1 Process impurities; 1.2.2 Degradation impurities; 1.2.3 Contamination impurities; 1.2.4 Other impurities; 1.3 Control of drug substance impurities; 1.3.1 Control of residual solvents; 1.3.2 Control of synthetic impurities; 1.3.3 Control of impurities in biological and botanical products; 1.3.4 Purification processes; 1.3.5 Control of impurities from packaging; 1.3.6 Control of contamination impurities 327 $a1.3.7 Control of degradants on stability1.4 Measurement of drug substance impurities; 1.4.1 HPLC; 1.4.2 GC; 1.4.3 CE; 1.4.4 General considerations; 1.5 Conclusions; Disclaimer; References; 2 Organic impurities in drug products: origin, control and measurement; 2.1 Introduction; 2.2 Analytical methodology; 2.3 Drug-excipient compatibility experimental design; 2.4 Degradation mechanisms; 2.5 Excipients' role in drug product destabilisation; 2.6 Processing as a source of moisture; 2.7 Hydrolysis; 2.8 Oxidation; 2.9 Photolysis; 2.10 Impact of processing on photostability 327 $a2.11 Miscellaneous reactions2.12 Container-closure systems; References; 3 Stereochemical impurities; 3.1 Introduction; 3.2 Separation techniques: direct resolution; 3.2.1 HPLC using CSPs; 3.2.2 HPLC using chiral mobile-phase additives; 3.2.3 Capillary electrophoresis using chiral selectors; 3.2.4 Supercritical fluid chromatography using chiral stationary phases; 3.2.5 Gas chromatography using chiral stationary phases; 3.3 Separation techniques: indirect resolution; 3.4 Non-separation techniques; 3.4.1 Chiroptical spectroscopy; 3.4.2 Nuclear magnetic resonance spectroscopy; 3.5 Conclusions 327 $aAcknowledgementsReferences; 4 Low-level measurement of potent toxins; 4.1 Introduction; 4.2 Classes of genotoxic impurity; 4.2.1 Alkylating agents; 4.2.2 Reactive amines; 4.2.3 Fused tricyclics; 4.2.4 Substituted purines and pyrimidines; 4.2.5 Hydroperoxides; 4.3 The analytical challenge of genetic; 4.4 Gas chromatography; 4.4.1 Sample introduction techniques; 4.4.2 Detectors; 4.5 High-performance liquid chromatography; 4.5.1 Separation modes; 4.5.2 Detection techniques; 4.6 Supercritical fluid chromatography; 4.7 Thin-layer chromatography; 4.8 Sample pre-concentration 327 $a4.8.1 Liquid-liquid extraction4.8.2 Solid-phase extraction; 4.8.3 Solid-phase microextraction; 4.8.4 Liquid-phase microextraction; 4.9 Other techniques; 4.9.1 Electrochemical measurements; 4.9.2 Derivatisation methods; 4.10 Adapting analytical methods from fields beyond pharmaceuticalsimpurities analysis; 4.10.1 Antineoplastic agents; 4.10.2 Other fields; 4.11 Validation of trace analytical methods; 4.11.1 Sensitivity; 4.11.2 Specificity; 4.11.3 Accuracy; 4.11.4 Solution stability; 4.11.5 Linearity and precision; 4.12 Conclusions; References; 5 A systematic approach to impurity identification 327 $a5.1 Introduction 330 $aA key component of the overall quality of a pharmaceutical is control of impurities, as their presence, even in small amounts, may affect drug safety and efficacy. The identification and quantification of impurities to acceptable standards presents a significant challenge to the analytical chemist. Analytical science is developing rapidly and provides increasing opportunity to identify the structure, and therefore the origin and safety implications of these impurities, and the challenges of their measurement drives the development of modern quantitative methods.Written for both practic 410 0$aAnalytical chemistry series. 606 $aDrugs$xAnalysis 606 $aMateria medica 615 0$aDrugs$xAnalysis. 615 0$aMateria medica. 676 $a615.1901 676 $a615/.1901 701 $aSmith$b Richard J$0118377 701 $aWebb$b Michael L$092608 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a996218619503316 996 $aAnalysis of drug impurities$92202139 997 $aUNISA LEADER 03745nam 2200481 450 001 9910808187503321 005 20220602195958.0 010 $a987-760-219-9 035 $a(CKB)4100000009152184 035 $a(MiAaPQ)EBC5885707 035 $a(Au-PeEL)EBL5885707 035 $a(OCoLC)1114972015 035 $a(MiAaPQ)EBC6802594 035 $a(Au-PeEL)EBL6802594 035 $a(OCoLC)1285782551 035 $a(OCoLC)1230507016 035 $a(FINmELB)ELB117737 035 $a(EXLCZ)994100000009152184 100 $a20220602d2018 uy 0 101 0 $aspa 135 $aurcnu|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aNarrativas pedago?gicas y TIC $eexperiencias de supervisio?n, gestio?n directiva y pra?ctica docente /$fcompilado por Pablo Rube?n Tenaglia ; pro?logo de Arturo Moya 210 1$aCo?rdoba :$cEditorial Brujas,$d[2018] 210 4$d©2018 215 $a1 online resource (216 pages) 311 $a987-760-184-2 327 $aNarrativas pedago?gicas y TIC -- Pa?gina legal -- I?ndice -- Pro?logo -- Introduccio?n -- Capi?tulo I. "Investigando ¡Gestamos cultura de paz! TIC-TAC- TEP" -- Capi?tulo II. "Laboratorio de Visiones" -- Capi?tulo III. "El Pi?lulas de Extensa?o: memoria institucional a trave?s de podcasts" -- Capi?tulo IV. "El uso de las TIC en la escolaridad secundaria" -- Capi?tulo VI. "Uso pedago?gico de las netbooks en elISFD "Dra. Carolina Tobar Garci?a" -- Capi?tulo VII. "La experiencia del autoconcepto en (...) -- Capi?tulo VIII. "Del recreo sin celular al mundode las pantallas" -- Capi?tulo IX. "Recursos educativos contextualizados (...) -- Capi?tulo X. "Construyendo ciudadani?a" -- Capi?tulo XI. "Una experiencia de acompan?amiento en (...) -- Capi?tulo XII. "Metodologi?a de la ensen?anza del disen?o (...) -- Capi?tulo XIII. "La comunicacio?n desde la perspectiva Tecnolo?gica Digital" -- Capi?tulo XIV. "Una experiencia de narrar: movimiento en revista" -- Capi?tulo XV. "Un di?a programando con un gato (...) -- Capi?tulo XVI. "Los programas acade?micos virtuales en (...) -- Capi?tulo XVII. "Las tutorias virtuales en la formacio?n (...). 330 $aEl siglo XXI y todos los cambios producidos en funcio?n del avance de la "Era Digital" hacen que los docentes se deban adaptar a un nuevo paradigma dida?ctico con diferentes competencias a adquirir en funcio?n de las demandas de los estudiantes.A su vez, en este nuevo y potencial marco educativo, las narrativas propician ser un buen ge?nero para la socializacio?n e intercambio de experiencias pedago?gicas significativas. E?stas, siempre a partir de su sistematizacio?n y documentacio?n posibilitan la circulacio?n constante de buenas pra?cticas educativas, actos de gestio?n y/o supervisio?n, las que facilitan una nueva forma de ensen?ar a partir de las nuevas ganas de aprender.El presente libro abarca una compilacio?n de relatos a?ulicos y extra-a?ulicos que narran vivencias originales y u?nicas en el contexto latinoamericano, haciendo que una nueva ensen?anza pase a ser el protagonista principal de este proceso, siempre, en todo al uso y apropiacio?n de las Tecnologi?as de Informacio?n y Comunicacio?n (TIC), herramientas, recursos y materiales fundamentales y fundacionales de esta nueva e?poca. 606 $aInformation technology 615 0$aInformation technology. 676 $a004 700 $aTenaglia$b Pablo Rube?n$01205432 702 $aMoya Moreno$b Arturo 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910808187503321 996 $aNarrativas pedago?gicas y TIC$93997782 997 $aUNINA