LEADER 05195nam 22006374a 450 001 996214620903316 005 20230617005414.0 010 $a1-280-19691-2 010 $a9786610196913 010 $a0-470-98842-8 010 $a1-4051-4471-8 035 $a(CKB)1000000000342018 035 $a(EBL)233024 035 $a(OCoLC)130848715 035 $a(SSID)ssj0000226491 035 $a(PQKBManifestationID)11200484 035 $a(PQKBTitleCode)TC0000226491 035 $a(PQKBWorkID)10258088 035 $a(PQKB)11040762 035 $a(MiAaPQ)EBC233024 035 $a(EXLCZ)991000000000342018 100 $a20040722d2005 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aPreparative enantioselective chromatography$b[electronic resource] /$fedited by Geoffrey B Cox 205 $a1st ed. 210 $aAmes, Iowa $cBlackwell Pub.$d2005 215 $a1 online resource (346 p.) 300 $aDescription based upon print version of record. 311 $a1-4051-1870-9 320 $aIncludes bibliographical references and index. 327 $aPreparative Enantioselective Chromatography; Contents; Contributors; Preface; 1. Chiral chromatography in support of pharmaceutical process research; 1.1 Introduction; 1.2 A brief introduction to chirality; 1.3 Why chirality is important; 1.4 Accessing enantiopurity: a brief overview of approaches; 1.4.1 Enantiopure starting materials: the chiral pool; 1.4.2 Removable enantioenriched auxiliaries; 1.4.3 Enantioselective catalysis; 1.4.4 Resolution technologies: introduction; 1.4.5 Chromatographic productivity is the key metric for preparative chromatography 327 $a1.4.6 Stationary phases for preparative chiral chromatography1.4.7 Advantages of preparative chiral chromatography over other approaches for accessing enantiopure materials; 1.4.8 Simulated moving bed enantioseparation; 1.5 Green enantioseparation; 1.6 What is the appropriate role of preparative chromatography in organic synthesis?; 1.7 Fording the river at the easiest point: some observations on the appropriate placement of a chromatographic resolution within a chiral synthesis; 1.8 Origins of preparative chiral chromatography 327 $a1.9 Practical tips for preparative chromatographic enantioseparation1.10 Conclusion; 2. Introduction to preparative chromatography; 2.1 Introduction; 2.2 Adsorption isotherms; 2.2.1 The simple case - the Langmuir isotherm; 2.2.2 Other isotherms; 2.2.3 Competitive isotherms; 2.3 Kinetics; 2.4 Metrics for preparative operations; 2.4.1 Throughput; 2.4.2 Production rate; 2.4.3 Productivity; 2.4.4 Specific productivity; 2.4.5 Cost; 2.5 The influence of chromatographic parameters on preparative chromatography; 2.5.1 Effect of particle size on preparative performance; 2.5.2 Effects of pressure 327 $a2.5.3 Effects of column efficiency2.5.4 Effect of column length; 2.5.5 The effects of selectivity; 2.6 Economics of preparative separations; 2.6.1 Point of insertion of the chromatographic resolution in the synthetic route; 3 Chiral stationary phases for preparative enantioselective chromatography; 3.1 Summary; 3.2 Introduction; 3.3 Historical development of CSPs for preparative chromatography; 3.4 Preparative CSPs; 3.4.1 Classification of CSPs; 3.4.2 Polymeric phases; 3.4.3 Brush-type CSPs; 3.4.4 Chiral phases for ligand-exchange chromatography; 3.4.5 Imprinted phases 327 $a3.5 Chemical and physical properties of CSPs3.5.1 Loading capacity; 3.5.2 Chemical and physical stability; 3.5.3 Solubility of the chiral solute; 3.6 New and future developments in the field of preparative CSPs; 3.6.1 CSPs with improved loading capacity; 3.6.2 CSPs with improved selectivity; 3.6.3 Immobilised polysaccharide-based CSPs; 3.7 Conclusion; 4 Method development for preparative enantioselective chromatography; 4.1 Introduction; 4.2 Chiral stationary phases for enantioselective chromatography; 4.3 Screening and optimisation strategy for preparative chiral chromatography 327 $a4.3.1 Choice of the stationary phase 330 $aThe development of chiral liquid chromatography, facilitating the straightforward separation of enantiomers, was a significant advance in chromatography, leading to widespread application in analytical chemistry. Application in preparative chromatography has been less rapid, but with the development of single enantiomer pharmaceuticals its use is increasingly common in chemical synthesis at laboratory, pilot plant and even full production scale. Brings non-experts up to speed quickly and comprehensively, facilitating the rapid development of effective separations of enantiomeri 606 $aLiquid chromatography 606 $aEnantiomers$xSeparation 615 0$aLiquid chromatography. 615 0$aEnantiomers$xSeparation. 676 $a543.089 676 $a543.84 676 $a543/.84 701 $aCox$b Geoffrey J.$f1952-$0969193 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a996214620903316 996 $aPreparative enantioselective chromatography$92202110 997 $aUNISA