LEADER 03649nam 2200637 450 001 9910137224603321 005 20230621141328.0 010 $a9782889192694$b(ebook) 035 $a(CKB)3710000000520088 035 $a(WaSeSS)IndRDA00058532 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/60236 035 $a(EXLCZ)993710000000520088 100 $a20160628h20142014 fy 0 101 0 $aeng 135 $aur||#|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aSudden arrhythmic death $efrom basic science to clinical practice /$ftopic editors, Ian N. Sabir, Christopher L.-H. Huang and Gareth D. Matthews 210 $cFrontiers Media SA$d2014 210 1$a[Lausanne, Switzerland] :$cFrontiers Media SA,$d2014. 210 4$d©2014 215 $a1 online resource (136 pages) $cillustrations; digital file(s) 225 1 $aFrontiers Research Topics,$x1664-8714 300 $a"Published in: Frontiers in Physiology" -- front cover. 311 08$aPrint version: 2889192695 320 $aIncludes bibliographical references. 330 $aWith upwards of 4.5 million deaths worldwide each year, and more than one tenth of these occurring in those with no previously documented heart disease, sudden arrhythmic death (SAD) is both a major public health burden and a highly emotive issue for society at large. Recent years have witnessed a marked expansion in our knowledge of the physiology underlying SAD, both in the context of hereditary and acquired cardiac disorders. Thanks largely to work in genetically modified animals, the growth in our understanding of mechanisms underlying arrhythmia in the hereditary channelopathies has been particularly marked. Our growing knowledge of the fundamental mechanisms underlying SAD has so far failed to spur substantial developments in clinical practice. Despite a large body of work in both humans and animals, it remains impossible to confidently identify those at high risk of SAD, making pre-emptive therapy a challenge. What is more, with the thankful exception of the implantable cardioverter-defibrillators and pharmacological agents in very specific situations, there has been depressingly little progress in finding new and effective therapies. This Research Topic aims to go some way towards bridging the gap between advances in basic science and the development and delivery of new therapies. 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