LEADER 05489nam 22007335 450 001 996208605803316 005 20230621141316.0 010 $a3-319-16104-0 024 7 $a10.1007/978-3-319-16104-4 035 $a(CKB)3710000000403943 035 $a(SSID)ssj0001500651 035 $a(PQKBManifestationID)11852494 035 $a(PQKBTitleCode)TC0001500651 035 $a(PQKBWorkID)11518474 035 $a(PQKB)11685385 035 $a(DE-He213)978-3-319-16104-4 035 $a(MiAaPQ)EBC3110060 035 $a(MiAaPQ)EBC6422901 035 $a(Au-PeEL)EBL6422901 035 $a(OCoLC)1231608706 035 $a(PPN)185485731 035 $a(EXLCZ)993710000000403943 100 $a20150429d2015 u| 0 101 0 $aeng 135 $aurnn#008mamaa 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 14$aThe Impact of Food Bioactives on Health $ein vitro and ex vivo models /$fedited by Kitty Verhoeckx, Paul Cotter, Iván López-Expósito, Charlotte Kleiveland, Tor Lea, Alan Mackie, Teresa Requena, Dominika Swiatecka, Harry Wichers 205 $a1st ed. 2015. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2015. 215 $a1 online resource (xvii, 338 pages) $ccolour illustrations; digital, PDF file(s) 300 $aBibliographic Level Mode of Issuance: Monograph 311 $a3-319-15791-4 320 $aIncludes bibliographical references and index. 327 $aIntroduction -- Gastrointestinal digestion models, general introduction -- Static digestion models general introduction -- InfoGest consensus method -- Approaches to static digestion models -- Dynamic digestion models general introduction -- The TNO gastro-Intestinal Model (TIM) -- Dynamic Gastric Model (DGM) -- Human Gastric Simulator (Riddet model) -- The DIDGI® System -- General introduction to cells, cell lines and cell culture -- Epithelial cell models; General introduction -- Caco-2 cell line -- HT29 cell line -- The IPEC-J2 cell line -- Co-cultivation of Caco-2 and HT-29MT -- Innate and adaptive immune cells; General introduction -- THP-1 and U937 cells -- Peripheral blood mononuclear cells -- PBMC-derived T cells -- Dendritic Cells -- Co-culture Caco-2/ immune cells -- Enteroendocrine Cell Models: General introduction -- STC-1 cells -- NCI-H716 cells -- Murine GLUTag cells -- In vitro intestinal tissue models: General introduction -- Intestinal crypt organoids as experimental models -- Porcine ex vivo intestinal segment model -- Ussing chamber -- In vitro fermentation models: General Introduction -- One compartment fermentation model -- The TNO in vitro model of the colon - TIM-2 -- The Simulator of the Human Intestinal Microbial Ecosystem ? SHIME® -- The computer-controlled multicompartmental dynamic model of the gastrointestinal system SIMGI. 330 $aThis book describes in vitro and ex vivo models that can be employed to investigate effects of digested food products on the GIT, or specific components thereof. Many such models exist and include, for example, those used to study digestion and fermentation in the small and large intestine, to investigate absorption (e.g. Ussing chamber, epithelial cell systems), and to research the immune and enteroendocrine responses (e.g. macrophages, dendritic cells, co-cultures). In each case, these respective assays and models are discussed, and tips and tricks concerning their proper use are given. The Impact of Food Bioactives on Health: In Vitro and Ex Vivo Models is an asset to researchers wishing to study the health benefits of their foods and food bioactives of interest. The book highlights which in vitro/ex vivo assays are of greatest relevance to their goals, what sort of outputs/data can be generated, and highlights the strengths and weaknesses of the various assays. It is also an important resource for under-graduate students in the ?food and health? arena. 606 $aMicrobiology 606 $aFood?Biotechnology 606 $aHuman physiology 606 $aFood Microbiology$3https://scigraph.springernature.com/ontologies/product-market-codes/L23040 606 $aFood Science$3https://scigraph.springernature.com/ontologies/product-market-codes/C15001 606 $aHuman Physiology$3https://scigraph.springernature.com/ontologies/product-market-codes/B13004 615 0$aMicrobiology. 615 0$aFood?Biotechnology. 615 0$aHuman physiology. 615 14$aFood Microbiology. 615 24$aFood Science. 615 24$aHuman Physiology. 676 $a664.001579 702 $aVerhoeckx$b Kitty$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aCotter$b Paul$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aLópez-Expósito$b Iván$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aKleiveland$b Charlotte$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aLea$b Tor$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aMackie$b Alan$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aRequena$b Teresa$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aSwiatecka$b Dominika$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aWichers$b Harry$4edt$4http://id.loc.gov/vocabulary/relators/edt 801 0$bUkMaJRU 906 $aBOOK 912 $a996208605803316 996 $aThe Impact of Food Bioactives on Health$92275612 997 $aUNISA