LEADER 03992nam 2200697 a 450 001 996206964103316 005 20230417204558.0 010 $a1-280-78393-1 010 $a9786613694324 010 $a0-470-72058-1 010 $a0-470-71826-9 035 $a(CKB)1000000000688127 035 $a(EBL)703897 035 $a(OCoLC)797918458 035 $a(SSID)ssj0000926872 035 $a(PQKBManifestationID)11559803 035 $a(PQKBTitleCode)TC0000926872 035 $a(PQKBWorkID)10899755 035 $a(PQKB)11251924 035 $a(SSID)ssj0000715467 035 $a(PQKBManifestationID)11956100 035 $a(PQKBTitleCode)TC0000715467 035 $a(PQKBWorkID)10703731 035 $a(PQKB)11525710 035 $a(MiAaPQ)EBC703897 035 $a(Au-PeEL)EBL703897 035 $a(CaPaEBR)ebr10575687 035 $a(CaONFJC)MIL369432 035 $a(EXLCZ)991000000000688127 100 $a19800512d1980 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aProtein degradation in health and disease 210 1$aAmsterdam ;$aNew York :$cExcerpta Medica,$d1980. 215 $a1 online resource (430 pages) $cillustrations 225 1 $aCiba Foundation symposium ;$v75 (new ser.) 300 $aDescription based upon print version of record. 311 0 $a0-470-66386-3 311 0 $a0-444-90148-5 320 $aIncludes bibliographical references and indexes. 327 $aProtein Degradation in Health and Disease; Contents; Discussion; Introduction: the classification of proteinases; Discussion; Lysosomal cysteine proteinases; Discussion; Cathepsin D: the lysosomal aspartic proteinase; Discussion; Human leucocyte elastase and cathepsin G: structural and functional characteristics; Discussion; Human collagenases: comparative and immunolocalization studies; Discussion; Proteinases in connective tissue breakdown; Discussion; Cellular mechanisms of proteinase release from inflammatory cells and the degradation of extracellular proteins; Discussion 327 $aInactivation of cytosol enzymes by a liver membrane protein; Discussion; Lysosomes and protein degradation; Discussion; Insights into mechanisms of intracellular protein turnover from studies on pinocytosis; Discussion; Turnover and degradation of mitochondria and their proteins; Discussion; Protein degradation in cells in culture; Discussion; Regulation of protein breakdown in hepatocyte monolayers; Discussion; A possible role for neutral proteolysis in the degradation of intracellular proteins; Discussion; Studies of the ATP dependence of protein degradation in cells and cell extracts 327 $aDiscussion; Coordination of protein synthesis and degradation; Discussion; General discussion Sites of protein degradation; Application of liver perfusion as an in vitro model in studies of intracellular protein degradation; Protein degradation and the regulation of protein balance in muscle; Discussion; Protein degradation in metabolic and nutritional disorders; Discussion; Proteinase inhibitors in severe inflammatory processes (septic shock and experimental endotoxaemia): biochemical, pathophysiological and therapeutic aspects; Discussion; Neutral proteinases of leucocytes and the inflammatory process; Discussion; Final general discussion; Concluding remarks; Index of contributors; Subject index 410 0$aCiba Foundation symposium ;$vnew ser. 75. 606 $aProteins$xMetabolism$vCongresses 606 $aProteolytic enzymes$vCongresses 606 $aPhysiology, Pathological$vCongresses 615 0$aProteins$xMetabolism 615 0$aProteolytic enzymes 615 0$aPhysiology, Pathological 676 $a616.3/995 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a996206964103316 996 $aProtein degradation in health and disease$92205631 997 $aUNISA