LEADER 05756nam 22007214a 450 001 996205512603316 005 20230617005459.0 010 $a1-280-74787-0 010 $a9786610747870 010 $a0-470-98845-2 010 $a1-4051-7319-X 035 $a(CKB)1000000000341982 035 $a(EBL)284301 035 $a(OCoLC)437176174 035 $a(SSID)ssj0000228135 035 $a(PQKBManifestationID)12029325 035 $a(PQKBTitleCode)TC0000228135 035 $a(PQKBWorkID)10148758 035 $a(PQKB)11629985 035 $a(MiAaPQ)EBC284301 035 $a(EXLCZ)991000000000341982 100 $a20041217d2005 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aProcess analytical technology$b[electronic resource] $espectroscopic tools and implementation strategies for the chemical and pharmaceutical industries /$fedited by Katherine A. Bakeev 210 $aOxford, UK ;$aAmes, Iowa $cBlackwell Pub.$d2005 215 $a1 online resource (476 p.) 300 $aDescription based upon print version of record. 311 $a1-4051-2103-3 320 $aIncludes bibliographical references and index. 327 $aProcess Analytical Technology : Spectroscopic Tools and Implementation Strategies for the Chemical and Pharmaceutical Industries; Contents; Contributors; Preface; List of Abbreviations; 1 Process Analytical Chemistry: Introduction and Historical Perspective; 1.1 Historical perspective; 1.2 Early instrument development; 1.3 Sampling systems; 1.4 Examples; References; 2 Implementation of Process Analytical Technologies; 2.1 Introduction to implementation of process analytical technologies (PATs) in the industrial setting; 2.1.1 Definition of process analytics 327 $a2.1.2 Differences between process analyzers and laboratory analysis2.1.3 General industrial drivers for process analytics; 2.1.4 Types of applications (R&D vs. Manufacturing); 2.1.5 Organizational considerations; 2.2 Generalized process analytics work process; 2.2.1 Project identification and definition; 2.2.2 Analytical application development; 2.2.3 Design, specify and procure; 2.2.4 Implementation in production; 2.2.5 Routine operation; 2.2.6 Continuous improvement; 2.3 Differences between implementation in chemical and pharmaceutical industries; 2.3.1 Introduction; 2.3.2 Business model 327 $a2.3.3 Technical differences2.3.4 Regulatory differences; 2.4 Conclusions; References; 3 Near-Infrared Spectroscopy for Process Analytical Chemistry: Theory, Technology and Implementation; 3.1 Introduction; 3.2 Theory of near-infrared spectroscopy; 3.2.1 Molecular vibrations; 3.2.2 Anharmonicity of the potential well; 3.2.3 Combination and overtone absorptions in the near-infrared; 3.2.4 Examples of useful near-infrared absorption bands; 3.3 Analyser technologies in the near-infrared; 3.3.1 The scanning grating monochromator; 3.3.2 Light sources and detectors for near-infrared analysers 327 $a3.3.3 The polychromator photodiode-array analyser3.3.4 The acousto-optic tunable (AOTF) analyser; 3.3.5 Fourier transform near-infrared analysers; 3.4 The sampling interface; 3.4.1 Introduction; 3.4.2 Further discussion of sampling issues; 3.4.3 The use of fibre-optics; 3.5 Conclusion; Bibliography; 4 Infrared Spectroscopy for Process Analytical Applications; Abstract; 4.1 Introduction; 4.2 Basic IR spectroscopy; 4.3 Instrumentation design and technology; 4.4 Process IR instrumentation; 4.4.1 Commercially available IR instruments; 4.4.2 Important IR component technologies 327 $a4.4.3 New technologies for IR components and instruments4.4.4 Requirements for process infrared analyzers; 4.4.5 Sample handling for IR process analyzers; 4.4.6 Issues for consideration in the implementation of process IR; 4.5 Applications of process IR analyzers; 4.6 Process IR analyzers: A review; 4.7 Trends and directions; References; 5 Process Raman Spectroscopy; 5.1 How Raman spectroscopy works; 5.2 When Raman spectroscopy works well and when it does not; 5.2.1 Advantages; 5.2.2 Disadvantages and risks; 5.3 What are the special design issues for process Raman instruments?; 5.3.1 Safety 327 $a5.3.2 Laser wavelength selection 330 $aThe use of real or near real time measurement of chemical production process parameters as the basis for achieving control or optimisation of a manufacturing process has wide application in the petrochemical, food and chemical industries. Process analytical chemistry (PAC), or process analytical technology (PAT) as it has recently been called, is now being deployed in the pharmaceutical industry, where it is seen as a technology that can help companies to improve their conformity with manufacturing compliance regulations. The objective of this book is to provide a starting point 606 $aChemical process control$xIndustrial applications 606 $aChemistry, Technical 606 $aChemistry, Analytic$xTechnological innovations 606 $aChemistry, Analytic$xTechnique 606 $aSpectrum analysis 606 $aPharmaceutical chemistry 615 0$aChemical process control$xIndustrial applications. 615 0$aChemistry, Technical. 615 0$aChemistry, Analytic$xTechnological innovations. 615 0$aChemistry, Analytic$xTechnique. 615 0$aSpectrum analysis. 615 0$aPharmaceutical chemistry. 676 $a660.2 676 $a660.29 676 $a660/.2 701 $aBakeev$b Katherine A$0942478 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a996205512603316 996 $aProcess analytical technology$92126814 997 $aUNISA