LEADER 05393nam 2200673Ia 450 001 996202135403316 005 20230421044603.0 010 $a1-281-75874-4 010 $a9786611758745 010 $a3-527-61569-5 010 $a3-527-61568-7 035 $a(CKB)1000000000376626 035 $a(EBL)482205 035 $a(SSID)ssj0000251428 035 $a(PQKBManifestationID)11191525 035 $a(PQKBTitleCode)TC0000251428 035 $a(PQKBWorkID)10247309 035 $a(PQKB)11422153 035 $a(MiAaPQ)EBC482205 035 $a(MiAaPQ)EBC482364 035 $a(OCoLC)184983907 035 $a(EXLCZ)991000000000376626 100 $a19941013d1995 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aStereoselective synthesis$b[electronic resource] $ea practical approach /$fMiha?ly No?gra?di ; foreword by A.I. Meyers 205 $a2nd, thoroughly rev. and updated ed. 210 $aWeinheim ;$aNew York $cVCH$d1995 215 $a1 online resource (390 p.) 300 $aDescription based upon print version of record. 311 $a3-527-29243-8 311 $a3-527-29242-X 320 $aIncludes bibliographical references (p. [315]-358) and index. 327 $aStereoselective Synthesis; Contents; List of Symbols and Abbreviations; Introduction; 1 General Concepts of Stereoselective Synthesis; 1.1 Principles of Differentiating Molecules; 1.2 Characterization of Stereoisomers. Conformation and Configuration; 1.3 Intramolecular Symmetry. Topicity and Prochirality; 1.4 Selectivity in Chemistry; 1.4.1 Substrate Selectivity; 1.4.1.1 Substrate Diastereoselectivity (Diastereomer Selectivity); 1.4.1.2 Substrate Enantioselectivity (Enantiomer Selectivity). Kinetic Resolution; 1.4.2 Product Selectivity; 1.4.2.1 Formation of Stereoisomers 327 $a1.4.2.2 Conditions Necessary for Stereoselectivity1.4.2.3 Concept of Stereodifferentiation; 1.4.2.4 Methods for Inducing Stereoselectivity; 1.4.3 Stereoselective Synthetic Strategies; 1.4.3.1 Enantioconvergent Synthesis; 1.4.3.2 Selective Preparation of Both Enantiomers from a Single Substrate; 1.5 Kinetics and Thermodynamics of Stereoselective Reactions; 2 Stereoselective Catalytic Reductions; 2.1 Stereoselective Homogeneous Hydrogenations with Rhodium-, Ruthenium- and Iridium-Phosphine Catalysts; 2.1.1 Hydrogenation of Olefinic Bonds; 2.1.1.1 Chiral Phosphorus Containing Ligands 327 $a2.1.2 Enantioselective Catalytic Hydrogenation of Ketones and Imines2.1.3 Diastereoselective Hydrogenations in Homogeneous Phase; 2.2 Catalytic Hydrosilylation; 2.3 Heterogeneous Stereoselective Catalytic Hydrogenations; 2.3.1 Enantioselective Heterogeneous Catalytic Hydrogenations; 2.3.2 Diastereoselective Heterogeneous Catalytic Hydrogenations; 3 Stereoselective Non-Catalytic Reductions; 3.1 Enantioselective Reductions; 3.1.1 Chiral Lithium Aluminum Hydrides; 3.1.1.1 Reduction of Carbonyl Groups; 3.1.1.2 Reduction of C=N and C=C Bonds; 3.1.2 Chirally Modified Hydridoborates 327 $a3.1.3 Chiral Boranes and Boronates3.1.4 Enantioselective Reductions with Hydride Transfer from Carbon; 3.1.4.1 Chiral Trialkylboranes; 3.1.4.2 Chiral Metal Alkyls; 3.1.4.3 Chiral Metal Alkoxides; 3.1.4.4 Chiral 1 ,4-Dihydropyridines; 3.1.5 Correlation of Substrate Constitution and Enantioselectivity; 3.2 Diastereoselective Reductions of Carbonyl Groups; 3.2.1 Stereochemistry of Diastereoselective Ketone Reductions; 3.2.2 Practical Aspects of Diastereoselective Ketone Reductions; 4 Stereoselective Oxidations; 4.1 Enantioselective Oxidations; 4.1.1 Epoxidation with Chiral Oxidants 327 $a4.1.2 Oxidations in the Presence of Chiral Catalysts4.2 Diastereoselective Oxidations; 4.2.1 Diastereoselective Epoxidation; 4.2.2 Various Diastereoselective Oxidations; 5 Stereoselective Carbon-Carbon Bond Forming Reactions by Nucleophilic Addition to Carbonyl Groups; 5.1 Addition of Simple Nucleophiles to Carbonyl Compounds; 5.1.1 Enantioselective Additions; 5.1.2 Diastereoselective Additions; 5.1.3 Additions to C=N Bonds; 5.2 Additions Involving Allylmetal and Allylboron Compounds; 5.2.1 General Aspects of Allylmetal Addition; 5.2.2 Addition of Allylboron Compounds 327 $a5.2.3 Addition of Allyltitanium Compounds 330 $aThe state-of-the-art in stereoselective synthesis!Thoroughly revised and updated, this enlarged second edition offers a plethora of valuable information on methods and reagents in stereoselective synthesis. Methods have been selected for high efficiency and selectivity; mechanistic aspects are treated succinctly, with a strong emphasis on practical applications. For this new edition, material has been added on* homogeneous diastereoselective hydrogenations* enantioselective oxidations* novel, efficient chiral auxiliariesMuch of the information given is presented in figu 606 $aStereochemistry 606 $aStereoisomers 606 $aOrganic compounds$xSynthesis 615 0$aStereochemistry. 615 0$aStereoisomers. 615 0$aOrganic compounds$xSynthesis. 676 $a541.223 676 $a541.39 700 $aNo?gra?di$b M$01232052 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a996202135403316 996 $aStereoselective synthesis$92860701 997 $aUNISA