LEADER 05234nam 2200625Ia 450 001 996201852203316 005 20230421045032.0 010 $a1-4443-1373-8 010 $a1-282-37172-X 010 $a9786612371721 010 $a1-4443-1374-6 010 $a1-4051-4943-4 035 $a(CKB)1000000000457069 035 $a(EBL)470741 035 $a(OCoLC)609849778 035 $a(SSID)ssj0000112075 035 $a(PQKBManifestationID)11133968 035 $a(PQKBTitleCode)TC0000112075 035 $a(PQKBWorkID)10086493 035 $a(PQKB)10018760 035 $a(MiAaPQ)EBC470741 035 $a(EXLCZ)991000000000457069 100 $a19960724d1996 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $2rdacontent 182 $2rdamedia 183 $2rdacarrier 200 14$aThe biology of plasmids$b[electronic resource] /$fDavid K. Summers 210 $aOxford ;$aCambridge, Mass. $cBlackwell Science$dc1996 215 $a1 online resource (169 p.) 300 $aDescription based upon print version of record. 311 $a0-632-03436-X 320 $aIncludes bibliographical references and index. 327 $aThe Biology of Plasmids; Contents; Preface; 1: The Anatomy of Bacterial Plasmids; Prologue; The first word; 1.1 Early plasmid research; 1.1.1 Fertile beginnings; 1.1.2 Plasmids and antibiotic resistance; 1.2 Plasmid-encoded phenotypes; 1.2.1 The diversity of plasmid-borne genes; 1.2.2 Bacteriocin production and resistance; 1.2.3 Colicin production; 1.3 Plasmid classification; 1.3.1 Early attempts; 1.3.2 Incompatibility classification; 1.3.3 The molecular basis of plasmid incompatibility; 1.3.4 Shortcomings of incompatibility testing; 1.4 The structure and organization of plasmids 327 $a1.4.1 Topological considerations1.5 The preparation of plasmid DNA; 1.5.1 Caesium chloride density gradient centrifugation; 1.5.2 Rapid plasmid purification; 1.5.3 Gel electrophoresis of plasmid DNA; 1.6 Plasmid anatomy revisited; 1.6.1 Linear plasmids of Streptomyces; 1.6.2 Linear plasmids of Borrelia; 1.6.3 Linear plasmid telomeres; 2: The Unity of Plasmid Biology; 2.1 Essential plasmid functions; 2.1.1 Persistence; 2.1.2 Proliferation; 2.1.3 Cryptic plasmids; 2.2 Plasmids and prokaryote evolution; 2.2.1 Changing and yet staying the same; 2.2.2 Plasmids as libraries of genetic information 327 $a2.2.3 The division of labour between plasmid and chromosome2.2.4 Do plasmids ever carry essential genes?; 2.3 Structural fluidity of plasmid genomes; 2.3.1 Transposons and plasmid structure; 2.3.2 Recombination and plasmid structure; 2.4 Where do plasmids come from?; 2.4.1 Plasmids and bacteriophages; 2.4.2 Parasites or symbionts?; 2.4.3 Plasmids, bacteriophages and transposons; 3: Plasmid Replication and its Control; 3.1 Essential components of replication control systems; 3.1.1 The need for replication control; 3.1.2 Basic principles of copy number control; 3.1.3 The basic replicon 327 $a3.1.4 Replication origins3.1.5 Multireplicon plasmids; 3.2 Strategies of replication control; 3.2.1 Passive control; 3.2.2 Active control; 3.3 Model systems of replication control; 3.3.1 The formulation of negative control models; 3.3.2 The Inhibitor Dilution model; 3.3.3 The Autorepressor model; 3.3.4 The kinetics of control: oscillation and over-shoot; 3.4 Genetic analysis of replication control; 3.4.1 cop and rep mutations; 3.4.2 Incompatibility studies; 3.5 The initiation of plasmid replication; 3.5.1 The role of Rep proteins; 3.5.2 Direct priming of replication 327 $a3.6 The control of plasmid replication3.6.1 Antisense RNA inhibitors; 3.6.2 ColEl-like plasmids; 3.6.3 Rom: a matchmaker protein; 3.6.4 pT181: transcriptional attenuation; 3.6.5 Plasmid R1: antisense control of a low copy number plasmid; 3.6.6 l-dv: regulation by a trans-acting protein; 3.6.7 The P1 prophage: titration and handcuffing; 3.7 The two-tier organization of control circuits; 3.7.1 CopB: a secondary inhibitor of R1 replication; 3.7.2 The role of ColE1 Rom; 3.8 Quantitative modelling of plasmid replication control; 4: Plasmid Inheritance; 4.1 The nature of plasmid instability 327 $a4.1.1 Segregational instability 330 $aPlasmids are closed, circular pieces of DNA that are able to self-replicate and are carried by many bacteria. They provide unique functions for bacteria by allowing them to sexually replicate and to pass on genetic material between each other. Plasmids are also responsible for the genetic factors that give resistance to antibiotics, and provide the enzymes needed to break down poorly metabolised food resources. The author has provided an updated treatment of the structure, function and application of plasmids suitable for undergraduates and medical students. 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