LEADER 04368nam 22009853u 450 001 9910790969803321 005 20230207232340.0 010 $a1-4522-5039-1 035 $a(CKB)2550000001194229 035 $a(EBL)1598455 035 $a(SSID)ssj0001119764 035 $a(PQKBManifestationID)12483152 035 $a(PQKBTitleCode)TC0001119764 035 $a(PQKBWorkID)11148568 035 $a(PQKB)11728838 035 $a(MiAaPQ)EBC1598455 035 $a(EXLCZ)992550000001194229 100 $a20140127d1997|||| u|| | 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aDelinquent Violent Youth$b[electronic resource] $eTheory and Interventions 210 $aThousand Oaks $cSAGE Publications$d1997 215 $a1 online resource (329 p.) 225 1 $aAdvances in Adolescent Development 300 $aDescription based upon print version of record. 311 $a1-322-41954-X 311 $a0-7619-1334-3 327 $aCover; Contents; Introduction; Chapter 1 - Reflections on Delinquency, Dickens, and Twain; Chapter 2 - Juvenile Justice and Delinquency Prevention in the United States: The Influence of Theories and Traditions on Policies and Practices; Chapter 3 - The Influence of Families, Friends, Schools, and Community on Delinquent Behavior; Chapter 4 - Adolescent Drug Use, Delinquency, and Other Behaviors; Chapter 5 - Life Imitating Art: Adolescents and Television Violence; Chapter 6 - Violent Offending in Adolescence: Epidemiology, Correlates, Outcomes, and Treatment 327 $aChapter 7 - Youth Gangs: A Developmental PerspectiveChapter 8 - A Comprehensive Review of Community-Based Approaches for the Treatment of Juvenile Offenders; Chapter 9 - Incarcerated Juvenile Offenders: Integrating Trauma-Oriented Treatment with State-of-the-Art Delinquency Interventions; Chapter 10 - Preventing Juvenile Delinquency and Promoting Juvenile Rightency; Index; About the Editors; About the Contributors 330 $aThis interdisciplinary volume provides a wide-ranging overview of the causes of criminal behaviour in children and adolescents. Following a literary and historical introduction, the contributors to this volume explore the theory and social policy that have shaped society's responses to young people in trouble. They then examine a number of key current issues, including: how families, peers, schools and the community influence delinquent behaviour; the role of substance abuse; the influence of television on violent behaviour; the nature and treatment of violent behaviour in adolesc 410 0$aAdvances in Adolescent Development 606 $aAdolescent Behavior 606 $aJuvenile delinquency -- Prevention 606 $aJuvenile Delinquency 606 $aAt-risk youth$xBehavior modification 606 $aViolence -- in adolescence 606 $aViolence in children 606 $aSocial Problems 606 $aCrime 606 $aBehavior 606 $aAge Groups 606 $aSociology 606 $aBehavior and Behavior Mechanisms 606 $aPersons 606 $aCriminology 606 $aSocial Sciences 606 $aMental Disorders 606 $aAdolescent Behavior 606 $aAdolescent 606 $aViolence 606 $aJuvenile Delinquency 615 4$aAdolescent Behavior. 615 4$aJuvenile delinquency -- Prevention. 615 4$aJuvenile Delinquency. 615 4$aAt-risk youth$xBehavior modification. 615 4$aViolence -- in adolescence. 615 4$aViolence in children. 615 2$aSocial Problems 615 2$aCrime 615 2$aBehavior 615 2$aAge Groups 615 2$aSociology 615 2$aBehavior and Behavior Mechanisms 615 2$aPersons 615 2$aCriminology 615 2$aSocial Sciences 615 2$aMental Disorders 615 2$aAdolescent Behavior 615 2$aAdolescent 615 2$aViolence 615 2$aJuvenile Delinquency 676 $a364.36 700 $aGullotta$b Thomas P$0938856 701 $aAdams$b Gerald R$0938857 701 $aMontemayor$b Raymond$01518505 801 0$bAU-PeEL 801 1$bAU-PeEL 801 2$bAU-PeEL 906 $aBOOK 912 $a9910790969803321 996 $aDelinquent Violent Youth$93859271 997 $aUNINA LEADER 02456nas 2200733-a 450 001 996201307803316 005 20240413023812.0 011 $a1918-7750 035 $a(CKB)110978984442921 035 $a(CONSER)cn-85039059- 035 $a(DE-599)ZDB2599234-X 035 $a(EXLCZ)99110978984442921 100 $a19841024b1984201u --- a 101 0 $aeng 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aScientia canadensis 210 $aThornhill, Ont. $cHSTC Publications$d©1984- 215 $a1 online resource 300 $aRefereed/Peer-reviewed 300 $aTitle from cover. 300 $a"Official journal of the history of Canadian science, technology and medicine." 300 $aPublished: Ottawa, Ont. : Canadian Science and Technology Historical Association, <1999-> 311 08$aPrint version: Scientia canadensis. 0829-2507 (DLC)cn 85039059 (OCoLC)11305775 517 1 $aJournal of the history of Canadian science, technology, and medicine 517 1 $aRevue d'histoire des sciences, des techniques et de la médecine au Canada 531 $aSCI CAN 531 0 $aSci. can. 606 $aScience$zCanada$xHistory$vPeriodicals 606 $aTechnology$zCanada$xHistory$vPeriodicals 606 $aMedicine$zCanada$xHistory$vPeriodicals 606 $aSciences$zCanada$xHistoire$vPériodiques 606 $aTechnologie$zCanada$xHistoire$vPériodiques 606 $aMedicine$2fast$3(OCoLC)fst01014893 606 $aScience$2fast$3(OCoLC)fst01108176 606 $aTechnology$2fast$3(OCoLC)fst01145078 606 $aHistory of Medicine 606 $aScience$xhistory 606 $aTechnology$xhistory 607 $aCanada$2fast 607 $aCanada 608 $aHistory.$2fast 608 $aPeriodicals.$2fast 608 $aPeriodicals.$2rbgenr 608 $aPeriodicals.$2lcgft 608 $aPeriodical. 615 0$aScience$xHistory 615 0$aTechnology$xHistory 615 0$aMedicine$xHistory 615 6$aSciences$xHistoire 615 6$aTechnologie$xHistoire 615 7$aMedicine. 615 7$aScience. 615 7$aTechnology. 615 2$aHistory of Medicine. 615 2$aScience$xhistory. 615 2$aTechnology$xhistory. 676 $a509/.71 906 $aJOURNAL 912 $a996201307803316 920 $aexl_impl conversion 996 $aScientia canadensis$92233942 997 $aUNISA LEADER 04576nam 22006375 450 001 9910424631003321 005 20251223190519.0 010 $a3-030-52321-7 024 7 $a10.1007/978-3-030-52321-3 035 $a(CKB)4100000011528432 035 $a(MiAaPQ)EBC6381831 035 $a(DE-He213)978-3-030-52321-3 035 $a(MiAaPQ)EBC6647494 035 $a(Au-PeEL)EBL6381831 035 $a(OCoLC)1235598745 035 $a(Au-PeEL)EBL6647494 035 $a(PPN)26030185X 035 $a(EXLCZ)994100000011528432 100 $a20201029d2020 u| 0 101 0 $aeng 135 $aurnn#008mamaa 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aMechanisms of Gene Regulation: How Science Works /$fby Carsten Carlberg, Ferdinand Molnár 205 $a1st ed. 2020. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2020. 215 $a1 online resource (XVI, 149 p. 71 illus., 70 illus. in color.) 311 08$a3-030-52320-9 320 $aIncludes bibliographical references. 327 $aCentral dogma of molecular biology -- Impact of chromatin structure -- Epigenetics enables gene expression -- Gene regulation in the context of nuclear architecture -- Core promoter -- TATA box and other core promoter elements -- Genome-wide core promoter identification -- TFIID and Mediator as paradigms of multi-protein complexes -- Site-specific transcription factors and their domains -- Classification of transcription factors -- Activation of transcription factors -- Programing cellular differentiation by transcription factors -- Inflammatory signaling via NF-KB -- Sensing cellular stress via p53 -- The nuclear receptor superfamily -- Molecular interactions of nuclear receptors -- Physiological role of nuclear receptors -- Next-generation sequencing -- Gene regulation in the context of Big Biology -- Exploring genome-wide transcription factor binding -- Integrating epigenome-wide datasets -- Cytosines and their methylation -- Histone modifications -- Gene regulation via chromatin modifiers -- Sensing energy metabolism via chromatin modifiers -- Epigenetics and chromatin -- Genome-wide understanding of epigenetics -- CTCF and genetic imprinting -- Epigenetics in health and disease -- Nucleosome positioning at promoters -- Chromatin remodeling -- Transcriptional dynamics in the presence of chromatin -- Organization of the nucleus -- Non-coding RNAs -- miRNAs and their regulatory potential -- Long ncRNAs -- Enhancer RNAs. 330 $aThis textbook aims to describe the fascinating area of eukaryotic gene regulation for graduate students in all areas of the biomedical sciences. Gene expression is essential in shaping the various phenotypes of cells and tissues and as such, regulation of gene expression is a fundamental aspect of nearly all processes in physiology, both in healthy and in diseased states. Th is pivotal role for the regulation of gene expression makes this textbook essential reading for students of all the biomedical sciences, in order to be better prepared for their specialized disciplines. A complete understanding of transcription factors and the processes that alter their activity is a major goal of modern life science research. The availability of the whole human genome sequence (and that of other eukaryotic genomes) and the consequent development of next-generation sequencing technologies have significantly changed nearly all areas of the biological sciences. For example, the genome-wide location of histone modifications and transcription factor binding sites, such as provided by the ENCODE consortium, has greatly improved our understanding of gene regulation. Therefore, the focus of this book is the description of the post-genome understanding of gene regulation. 606 $aMedicine$xResearch 606 $aBiology$xResearch 606 $aBiochemistry 606 $aGenetics 606 $aBiomedical Research 606 $aBiochemistry 606 $aGenetics and Genomics 615 0$aMedicine$xResearch. 615 0$aBiology$xResearch. 615 0$aBiochemistry. 615 0$aGenetics. 615 14$aBiomedical Research. 615 24$aBiochemistry. 615 24$aGenetics and Genomics. 676 $a572.865 700 $aCarlberg$b Carsten$0849346 702 $aMolna?r$b Ferdinand 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910424631003321 996 $aMechanisms of Gene Regulation$92496674 997 $aUNINA