LEADER 01125nam--2200373---450- 001 990003377920203316 005 20100310110726.0 010 $a978-88-15-12565-1 035 $a000337792 035 $aUSA01000337792 035 $a(ALEPH)000337792USA01 035 $a000337792 100 $a20100310d2009----km-y0itay50------ba 101 $aita 102 $aIT 105 $a||||||||001yy 200 1 $a<> seta in Italia$euna grande industria prima della rivoluzione$fCarlo Poni$ga cura di Vivian R. Gruder, Edmund Leites, Roberto Scazzieri 210 $aBologna$cIl Mulino$d2009 215 $aXXII, 598 p.$d22 cm 410 0$12001 454 1$12001 461 1$1001-------$12001 606 0 $aSeta$xIndustria$zSec. 16-18$2BNCF 676 $a338.47677390945 700 1$aPONI,$bCarlo$071346 801 0$aIT$bsalbc$gISBD 912 $a990003377920203316 951 $a338.476 PON 1$b65241 G.$c338.476 PON$d00256535 959 $aBK 969 $aECO 979 $aFIORELLA$b90$c20100310$lUSA01$h1105 979 $aFIORELLA$b90$c20100310$lUSA01$h1107 996 $aSeta in Italia$9243576 997 $aUNISA LEADER 03847nam 22006135 450 001 9910484259103321 005 20251113174211.0 010 $a3-030-66014-1 024 7 $a10.1007/978-3-030-66014-7 035 $a(CKB)4100000011891304 035 $a(MiAaPQ)EBC6566463 035 $a(Au-PeEL)EBL6566463 035 $a(OCoLC)1246644357 035 $a(PPN)255289820 035 $a(DE-He213)978-3-030-66014-7 035 $a(EXLCZ)994100000011891304 100 $a20210413d2021 u| 0 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aAge-related Macular Degeneration $eFrom Clinic to Genes and Back to Patient Management /$fedited by Emily Y. Chew, Anand Swaroop 205 $a1st ed. 2021. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2021. 215 $a1 online resource (317 pages) 225 1 $aAdvances in Experimental Medicine and Biology,$x2214-8019 ;$v1256 311 08$a3-030-66013-3 327 $a1. Age-Related Macular Degeneration: Epidemiology and Clinical Aspects -- 2. Ocular Imaging for Enhancing the Understanding, Assessment, and Management of Age-Related Macular Degeneration -- 3. Histopathology of Age-Related Macular Degeneration and Implications for Pathogenesis and Therapy -- 4. Bruch?s Membrane and the Choroid in Age-Related Macular Degeneration -- 5. Innate Immunity in Age-Related Macular Degeneration -- 6. Immunological Aspects of Age-Related Macular Degeneration -- 7. AMD Genetics: Methods and Analyses for Association, Progression, and Prediction -- 8. Making Biological Sense of Genetic Studies of Age-Related Macular Degeneration -- Age-Related Macular Degeneration: From Epigenetics to Therapeutic Implications -- 10. Mitochondria: The Retina?s Achilles? Heel in AMD -- 11. Cell-Based Therapies for Age-Related Macular Degeneration -- 12. Current Management of Age-Related Macular Degeneration. 330 $aThis edited book focuses on the recent advances in our understanding of age-related macular degeneration (AMD), combining epidemiology and clinical diagnosis, with genetics and immunological aspects as well as the role of proteostasis and mitochondria before diving into new therapies including stem cell based approaches. AMD is a leading cause of largely incurable blindness worldwide and projected to double from 2.07 million to 5.44 million individuals by 2050 in the United States. Globally, 288 million individuals are projected to have AMD by 2040. The disease has enormous socioeconomic impact on the affected individuals, their families and the society. This book will bring together the state of the art basic science knowledge with clinically relevant findings and address the challenges for future research in AMD. The intersection of different disciplines will provide potential areas for further investigations to reduce the burden of blindness from AMD. This book offers an appealing and insightful resource for clinicians, scientists, students and fellows. 410 0$aAdvances in Experimental Medicine and Biology,$x2214-8019 ;$v1256 606 $aMedical genetics 606 $aOphthalmology 606 $aHuman physiology 606 $aMedical Genetics 606 $aOphthalmology 606 $aHuman Physiology 615 0$aMedical genetics. 615 0$aOphthalmology. 615 0$aHuman physiology. 615 14$aMedical Genetics. 615 24$aOphthalmology. 615 24$aHuman Physiology. 676 $a617.7 676 $a617.735 702 $aChew$b Emily Y. 702 $aSwaroop$b Anand 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910484259103321 996 $aAge-related macular degeneration$92116600 997 $aUNINA