LEADER 01165nam--2200385---450- 001 990003028460203316 005 20071205110550.0 010 $a978-0-333-97602-9 035 $a000302846 035 $aUSA01000302846 035 $a(ALEPH)000302846USA01 035 $a000302846 100 $a20071205h2002----km-y0itay50------ba 101 $aeng 102 $aUS 105 $aah--||||001yy 200 1 $aGrammar foundations$fMichael Vince, Grazia Cerulli 210 $aOxford$cMacmillan Education$dcopyr. 2002 215 $a320 p.$cill.$d26 cm 606 0 $aLingua inglese$xGrammatica 676 $a428.2451 700 1$aVINCE,$bMichael$0260578 701 1$aCERULLI,$bGrazia$0425635 801 0$aIT$bsalbc$gISBD 912 $a990003028460203316 951 $aVII.3.D. 571$b57483 G.$cVII.3.$d00065396 951 $aVII.3.D. 571a$b57481 G.$cVII.3.$d00065386 951 $aVII.3.D. 571b$b57482 G.$cVII.3.$d00065391 959 $aBK 969 $aUMA 979 $aPAOLA$b90$c20071205$lUSA01$h1056 979 $aPAOLA$b90$c20071205$lUSA01$h1103 979 $aPAOLA$b90$c20071205$lUSA01$h1105 996 $aGrammar foundations$91025745 997 $aUNISA LEADER 02965nam 2200469z- 450 001 9910136802503321 005 20210212 035 $a(CKB)3710000000631105 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/57138 035 $a(oapen)doab57138 035 $a(EXLCZ)993710000000631105 100 $a20202102d2015 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aProgenitor diversity and neural cell specification in the central nervous system 210 $cFrontiers Media SA$d2015 215 $a1 online resource (107 p.) 225 1 $aFrontiers Research Topics 311 08$a2-88919-683-6 330 $aThe central nervous system continuously perceives, integrates, processes and generates information. These complex functions rely on the detailed elaboration of its cellular network and on the myriads of individual, highly differentiated and specialized cell types, classically subdivided into neurons, astrocytes and oligodendrocytes. The specification of these individual populations begins early during development with less differentiated, yet already partly restricted, progenitor cells. Anatomically located in dedicated germinative niches, neural progenitors perceive the influence of diffusible molecules of various natures and concentrations. These signals result in the initial specialization of cohorts of progenitors that express unique combinations of transcription factors. It is now clearly established that both extrinsic and intrinsic signals act in concert to determine the fate potentials of these progenitor cohorts. This limitation increases over time, adult neural progenitors being more restricted than their developmental counterparts. Nevertheless, recent data have shown that the fate restriction of neural progenitors, as well as that of their progenies, can be overwritten upon selected intrinsic factor expression, not only during development but also in adulthood. This e-book is a collection of original research studies along with review articles that, together, provide insights into the vast spatiotemporal diversity of neural progenitors, and the various factors that govern their fate potential. 606 $aNeurosciences$2bicssc 610 $aAstrocytes 610 $aCentral Nervous System 610 $aExtrinsic Signals 610 $aFate Restriction 610 $aneural progenitors 610 $aneurogenic niches 610 $aNeurons 610 $aoligodendrocytes 610 $aspecification 610 $aTranscription Factors 615 7$aNeurosciences 700 $aMarcos R. Costa$4auth$01280857 702 $aCecilia Hedin-Pereira$4auth 702 $aCaroline Rouaux$4auth 906 $aBOOK 912 $a9910136802503321 996 $aProgenitor diversity and neural cell specification in the central nervous system$93017544 997 $aUNINA