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(L.G.) M 71$c1$g1$i2008000108229$lle008$op$pE0.00$q-$rl$s- $t0$u0$v0$w0$x0$y.i14093145$z17-06-05 996 $aForensic linguistics$91106056 997 $aUNISALENTO 998 $ale008$b17-06-05$cm$da $e-$feng$gmau$h0$i0 LEADER 09029nam 22006735 450 001 9910886075203321 005 20250305031432.0 010 $a9783031484087 010 $a3031484088 024 7 $a10.1007/978-3-031-48408-7 035 $a(CKB)34605094900041 035 $a(MiAaPQ)EBC31653355 035 $a(Au-PeEL)EBL31653355 035 $a(DE-He213)978-3-031-48408-7 035 $a(EXLCZ)9934605094900041 100 $a20240831d2024 u| 0 101 0 $aeng 135 $aur||||||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aPrinciples and Practice of Emergency Research Response /$fedited by Robert A. Sorenson 205 $a1st ed. 2024. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2024. 215 $a1 online resource (1122 pages) 311 08$a9783031484070 311 08$a303148407X 327 $aSection I. Pandemic Preparedness and Research Response: A Necessary New Field -- 1. Introduction -- 2. Clinical Research on Infectious Diseases -- 3. Guiding Principles for Emergency Research Response -- Section II. Norms for Emergency Research Response -- 4. Ethics of Pandemic Research -- 4.1. In Practice: Vaccine Efficacy and Safety Testing - An Ethical Case for Individual Randomization -- 4.2. In Practice: Research Ethics Committee Review in Public Health Emergencies -- 5. Health Emergency Research amid Global Inequities -- 6. Meeting Regulatory Criteria and Seeking Licensure -- 7. Research, Sample, and Data Sharing During Outbreaks, Pandemics, and Beyond -- Section III. Preparedness for Emergency Research Response -- 8. Building Biomedical Research Capacity in Low- and Middle-Income Countries -- 9. Laboratory Needs for Research Response -- 10. Understanding How and Where Pathogens Emerge -- 11. Accelerating Diagnostic Innovation for Pandemic Control -- 12. Vaccine Candidates for Novel Pathogens.-12.1. In Focus: Novel Manufacturing Platforms for Pandemic Preparedness and Emergency Response -- 13. Accelerating Vaccine Development -- 14. Accelerating Development of Therapeutics for Preparedness, Response, and a More Secure World -- 14.1. In Practice: The RECOVERY Trial -- Section IV. Research Response -- 15. ACTIV: A U.S. Public-Private Partnership Responds to COVID-19 -- 15.1. In Practice: Leveraging an Integrated National Health System for Research Response -- 16. Challenges for Emergency Research Interventions in Fragile, Weak, and Failed Nation States -- 16.1. In Practice: Responding to an Infectious Disease Outbreak amid a Humanitarian Emergency -- 17. Integrating Clinical Research into Ebola Response: Liberia Case Study -- 17.1. In Practice: Integration of Clinical Research and Patient Care in the DRC PALM Ebola Therapeutics Trial -- 18. Good Participatory Practice. Social Mobilization, Communications, and Community Engagement -- 18.1. In Practice: Building Community Engagement for Clinical Research Response -- 18.2. In Practice: Adapting Social Analytics for Research Response -- 19. Understanding and Reporting the Natural History of an Infectious Disease -- 20. Turning Research Results into Clinical Practice Guidelines in Public Health Emergencies -- Section V. Methodology for Research Response -- 21. Epidemiological Research in the Setting of Outbreak Response -- 21.1. In Focus: The Impact and Mechanisms of Superspreading -- 22. Vaccine Trial Designs -- 22.1. In Focus: Ring Trial Design -- 23. Data and Safety Monitoring of Clinical Trials During Public Health Emergencies -- 23.1. In Practice: Monitoring the PALM Ebola Therapeutics Study in the Democratic Republic of the Congo -- 24. Mathematical Modeling for Emergency Response -- 25. Models in the COVID-19 Pandemic -- 25.1. Case Study: Modeling Fractional-Dose Emergency Vaccination Campaigns for Yellow Fever -- 26. Social Science Evidence for Outbreak and Pandemic Response -- Section VI. Governance, Institutions, and Partnerships -- 27. A Global Framework for Research Preparedness and Response -- 28. Financing Emergency Research Response during Infectious Disease Outbreaks -- 29. International Collaboration to Advance Research Preparedness and Response -- 30. Organizational Partnerships for Preparedness and Response to Emerging and Re-Emerging Infectious Diseases -- 30.1. In Focus: Research and Medical Humanitarian NGOs -- 30.2. In Practice: Building and Maintaining Preparedness for a Rapid Research Response in Indonesia -- Section VII. Research Operations -- 31. Operational Recommendations for Streamlining Emergency Research Responses to Pandemics -- 32. Launching a Clinical Research Operation -- 32.1. In Practice: Clinical Research Communications During an Outbreak -- 32.2. In Focus: Clinical Trial Insurance and Indemnification -- 33. Ethical Review of Research During an Emergency Response -- 33.1. In Practice: Ethical Review During Emergencies - The Liberian Experience -- 33.2. In Practice: Independent Monitoring of Emergency Response Clinical Trials -- 33.3. In Practice: Capacity Building for Research Ethics Review in Low- and Middle-Income Countries -- 34. Information and Communications Technology to Support Research Low-Resource Settings -- 35. Data Management in Emergency Response Research -- 36. Safety and Pharmacovigilance in Emergency Research Response -- 37. Supply and Logistics for Clinical Research in Low-Resource Settings -- 38. Pharmaceutical Management -- 39. Cold Chain and Electrical Power for Emergency Research Response -- 40. Selecting and Opening a Clinical Research Site in a Low-Resource Setting -- 40.1. In Practice: Improving Patient Care in the Field - The CUBE Isolation Unit -- 41. Management of Security for Clinical Trials During Emergencies -- 42. Locally Hired Staff for Clinical Research Sites in Low-Resource Settings. 330 $aRobust global health security requires effective preparation for and response to emerging and re-emerging pathogens. The nascent field of emergency research response and preparedness is a crucial component in preventing and mitigating outbreaks, yet it is rife with critical scientific, ethical, and policy questions. How can local, national, and global systems collaborate across disciplines and political boundaries to protect health security? How can we conduct rigorous research in fragile or failed nation-states? What is needed for equitable distribution of vaccines and therapeutic medicines in short supply? How can we accelerate trials of vaccines and therapeutics during an emergency without compromising scientific rigor or ethical standards? How do we integrate communities and stakeholders into research preparedness and response? The editors bring decades of experience to their collaboration with renowned research scientists and health policy experts. Together they have crafted a compendium that proposes normative standards and offers practical guidance for preparedness and rapid research response. This pioneering, open access textbook presents principles and practices forged from experience in health emergencies ? insights that illuminate a path forward for research response and preparedness. The goal is to stop outbreaks from becoming avoidable pandemics, and to mitigate illness, death, and social disruption if they cannot be stopped. Principles and Practice of Emergency Research Response merges historical understanding with insights into possible futures. It will serve as an indispensable compass for curtailing infectious disease threats through research, global health policy changes, and research capacity improvements where they are most needed. This book will be an ongoing reference for governments, health organizations, development agencies, researchers, policy experts, ethicists, and socialscientists. To facilitate focused and enhanced learning, it incorporates pedagogical tools such as abstracts, learning objectives, discussion questions, real-life examples, and learning tracks. 606 $aMedical microbiology 606 $aEmergency medical services 606 $aMedical sciences 606 $aInternal medicine 606 $aMedical Microbiology 606 $aEmergency Services 606 $aHealth Sciences 606 $aInternal Medicine 615 0$aMedical microbiology. 615 0$aEmergency medical services. 615 0$aMedical sciences. 615 0$aInternal medicine. 615 14$aMedical Microbiology. 615 24$aEmergency Services. 615 24$aHealth Sciences. 615 24$aInternal Medicine. 676 $a616.9041 700 $aHiggs$b Elizabeth S$01769127 701 $aSorenson$b Robert A$01769128 701 $aFallah$b Mosoka P$01769129 701 $aLurie$b Nicole$01769130 701 $aMcNay$b Laura A$01769131 701 $aSmith$b Peter G$0155758 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910886075203321 996 $aPrinciples and Practice of Emergency Research Response$94236897 997 $aUNINA