LEADER 01198nam--2200349---450 001 990002095760203316 005 20220616100314.0 035 $a000209576 035 $aUSA01000209576 035 $a(ALEPH)000209576USA01 035 $a000209576 100 $a20041020d1983----km-y0itay0103----ba 101 0 $aita 102 $aIT 105 $a||||||||001yy 200 1 $a<> riserve nell'economia dell'impresa$eriserve del bilancio, riserve operative, riserve di ricettivitą$fEnrico Cavalieri 210 $aPadova$cCEDAM$d1983 215 $aXV, 262 p.$d24 cm 225 2 $aPubblicazioni dell'Istituto di ragioneria, Facoltą di conomia e commercio, Universitą di Napoli$hSer. 2., 3 410 0$12001$aPubblicazioni dell'Istituto di ragioneria, Facoltą di conomia e commercio, Universitą di Napoli$iSer. 2., 3 454 1$12001 461 1$1001-------$12001 606 0 $aImprese$xEconomia$xRiserve 676 $a338 700 1$aCAVALIERI,$bEnrico$0108662 801 0$aIT$bsalbc$gISBD 912 $a990002095760203316 951 $aX 13 XVIII 3$b17540 E.C.$cX 13 XVIII 959 $aBK 969 $aGIU 996 $aRiserve nell'economia dell'impresa$962083 997 $aUNISA LEADER 04175nam 22006735 450 001 9910911294103321 005 20250807152858.0 010 $a9783031666865 010 $a3031666860 024 7 $a10.1007/978-3-031-66686-5 035 $a(MiAaPQ)EBC31805202 035 $a(Au-PeEL)EBL31805202 035 $a(CKB)36681978600041 035 $a(DE-He213)978-3-031-66686-5 035 $a(MiAaPQ)EBC31851879 035 $a(Au-PeEL)EBL31851879 035 $a(EXLCZ)9936681978600041 100 $a20241126d2024 u| 0 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aEpigenetic Mechanisms in Breast Cancer Therapy and Resistance /$fedited by Sanchita Bhatnagar 205 $a1st ed. 2024. 210 1$aCham :$cSpringer Nature Switzerland :$cImprint: Springer,$d2024. 215 $a1 online resource (108 pages) 225 1 $aAdvances in Experimental Medicine and Biology,$x2214-8019 ;$v1465 311 08$a9783031666858 311 08$a3031666852 320 $aIncludes bibliographical references and index. 327 $aChapter 1 - MDIG in breast cancer progression and metastasis -- Chapter 2 - Tumor Microenvironment and Epigenetic Implications in Breast Cancer Progression -- Chapter 3 - The Epigenetic Landscape of Breast Cancer, Metabolism, and Obesity -- Chapter 4 - Epigenetic Modulations by Microbiome in Breast Cancer -- Chapter 5 - Facilitates chromatin transcription in breast and other cancers -- Chapter 6 - Advances in epigenetic therapeutics for breast cancer -- Chapter 7 - Detection methods for epigenetic mechanisms in breast cancer. 330 $aEpigenetic mechanisms are essential for normal mammalian development and maintenance of gene expression patterns. Disruption of epigenetic processes can lead to altered transcriptional regulation, gene levels, and malignant cellular transformation. Global alterations of the epigenetic landscape are a hallmark of tumorigenesis and metastasis. Conventionally, cancer was thought to be a genetic disease, but recent advancement in the field identified an abundance of epigenetic abnormalities along with genetic alterations. The extensive reprogramming of epigenetic machinery in cancer includes DNA methylation, histone modifications, nucleosome positioning and non-coding RNAs, specifically microRNA expression. Additionally, the reversible nature of epigenetic aberrations has led to the emergence of the promising field of epigenetic therapy, and recent FDA approval of epigenetic drugs for cancer treatment. This book focuses on the epigenetic mechanisms in breast cancertherapy and resistance. It is organized into three sections, including epigenetic mechanisms in breast cancer, targeting epigenetic mechanisms for new therapies, and new and emerging methodologies to study epigenetic alterations in breast cancer. Chapters highlight various epigenetic regulations that prevent breast cancer growth and progression, as well as epigenetic alterations that contribute to breast cancer progression. This text is a useful methodology book for researchers and students interested in epigenetics in breast cancer and the fundamentals of cancer biology. 410 0$aAdvances in Experimental Medicine and Biology,$x2214-8019 ;$v1465 606 $aCancer$xGenetic aspects 606 $aEpigenetics 606 $aCancer$xTreatment 606 $aMedical microbiology 606 $aCancer Genetics and Genomics 606 $aEpigenetics 606 $aCancer Therapy 606 $aMedical Microbiology 615 0$aCancer$xGenetic aspects. 615 0$aEpigenetics. 615 0$aCancer$xTreatment. 615 0$aMedical microbiology. 615 14$aCancer Genetics and Genomics. 615 24$aEpigenetics. 615 24$aCancer Therapy. 615 24$aMedical Microbiology. 676 $a616.99449042 702 $aBhatnagar$b Sanchita 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910911294103321 996 $aEpigenetic Mechanisms in Breast Cancer Therapy and Resistance$94294552 997 $aUNINA