LEADER 01208nam--2200397---450 001 990001643420203316 005 20200917103423.0 035 $a000164342 035 $aUSA01000164342 035 $a(ALEPH)000164342USA01 035 $a000164342 100 $a20040510d1940----km-y0itay0103----ba 101 0 $aita 102 $aIT 105 $aa---||||001yy 200 1 $aAutunno del Medio Evo$fJohan Huizinga$gtraduzione dall'olandese di Bernardo Jasink 210 $aFirenze$cSansoni$d1940 215 $aVIII, 497 p., [9] carte di tav.$cill.$d24 cm. 225 2 $aBiblioteca storica Sansoni$iN. S.$v2 300 $aTraduzione della 3. ed olandese 410 0$12001$aBiblioteca storica Sansoni 454 1$12001$aHerfsttij der Middeleeuwen$915460 461 1$1001-------$12001 606 0 $aMedioevo$zSec. 14.-15. 676 $a840.1 700 1$aHUIZINGA,$bJohan$0292479 702 1$aJASINKI,$bBernardo 801 0$aIT$bsalbc$gISBD 912 $a990001643420203316 951 $aX.1.B. 161 (III A Coll. 31/2)$b46976 L.M.$cX.1.B. 951 $aFC M 1188$bDLM$cFC M 959 $aBK 969 $aUMA 969 $aDILAM 996 $aHerfsttij der Middeleeuwen$915460 997 $aUNISA LEADER 01899nam 2200373 450 001 9910688418103321 005 20230623121215.0 035 $a(CKB)5400000000040557 035 $a(NjHacI)995400000000040557 035 $a(EXLCZ)995400000000040557 100 $a20230623d2020 uy 0 101 0 $aeng 135 $aur||||||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aAmyotrophic Lateral Sclerosis /$fedited by Muralidhar L. Hegde 210 1$aLondon, United Kingdom :$cIntechOpen,$d2020. 215 $a1 online resource (160 pages) $cillustrations 311 $a1-83880-582-6 330 $aA flurry of recent research on the role of the RNA/DNA-binding proteins TDP-43 and FUS as well as a dozen other factors (e.g., C9ORF72 and profilin) has led to a new paradigm in our understanding of the pathobiology of the motor neuron disease, Amyotrophic Lateral Sclerosis (ALS). How these factors trigger neuromuscular dysfunction is critical for developing more effective ALS therapeutics. The 'gain-of-toxicity' or 'loss-of-function' of these etiological factors is a key question. Recent studies on the imbalance in genome damage versus repair have opened avenues for potential DNA repair-based therapeutics. This book highlights emerging science in the area of ALS and discusses key approaches and mechanisms essential for developing a cure for ALS. 517 $aAmyotrophic Lateral Sclerosis 606 $aAmyotrophic lateral sclerosis 606 $aAmyotrophic lateral sclerosis$xTreatment 615 0$aAmyotrophic lateral sclerosis. 615 0$aAmyotrophic lateral sclerosis$xTreatment. 676 $a616.83 702 $aHegde$b Muralidhar L. 801 0$bNjHacI 801 1$bNjHacl 906 $aBOOK 912 $a9910688418103321 996 $aAmyotrophic lateral sclerosis$92004420 997 $aUNINA