LEADER 01234nam1 2200409 450 001 990000705620203316 035 $a0070562 035 $aUSA010070562 035 $a(ALEPH)000070562USA01 035 $a0070562 100 $a20011023d--------km-y0itay0103----ba 101 $alat 102 $aBE 105 $a||||||||001yy 200 1 $aHermes Latinus$fdirettore del progetto Paolo Lucentini$gcomtato di redazione Lucia Ghilli, Sylvain Matton, Vittoria Perrone Compagni 210 $aTurnholti$cBrepols 215 $av.$d26 cm 410 $12001 676 $a299.93 700 1$aHERMES :$cTrismegistus$0187565 702 1$aGHILLI,$bLucia 702 1$aMATTON,$bSylvain 702 1$aPERRONE COMPAGNI,$bVittoria 702 1$aLUCENTINI,$bPaolo 801 0$aIT$bsalbc$gISBD 912 $a990000705620203316 951 $aIV A 854 BIS/144$bLM$cIV A 959 $aBK 969 $aUMA 979 $aPATTY$b90$c20011023$lUSA01$h2008 979 $aPATTY$b90$c20011023$lUSA01$h2022 979 $aPATTY$b90$c20011023$lUSA01$h2023 979 $c20020403$lUSA01$h1719 979 $aPATRY$b90$c20040406$lUSA01$h1649 979 $aANNAMARIA$b90$c20120720$lUSA01$h1157 996 $aHermes Latinus$9961406 997 $aUNISA LEADER 03694nam 2200685 450 001 9910463928103321 005 20211207030721.0 010 $a1-4008-5146-7 024 7 $a10.1515/9781400851461 035 $a(CKB)2670000000544965 035 $a(EBL)1642467 035 $a(OCoLC)874563217 035 $a(SSID)ssj0001136059 035 $a(PQKBManifestationID)12483332 035 $a(PQKBTitleCode)TC0001136059 035 $a(PQKBWorkID)11102797 035 $a(PQKB)11054121 035 $a(MiAaPQ)EBC1642467 035 $a(StDuBDS)EDZ0001059597 035 $a(MdBmJHUP)muse49017 035 $a(DE-B1597)454003 035 $a(OCoLC)979758913 035 $a(DE-B1597)9781400851461 035 $a(Au-PeEL)EBL1642467 035 $a(CaPaEBR)ebr10850252 035 $a(CaONFJC)MIL583051 035 $a(EXLCZ)992670000000544965 100 $a20140404h20142014 uy 0 101 0 $aeng 135 $aurnn#---|u||u 181 $ctxt 182 $cc 183 $acr 200 10$aHomology, genes, and evolutionary innovation /$fGu?nter P. Wagner 205 $aCourse Book 210 1$aPrinceton, New Jersey :$cPrinceton University Press,$d2014. 210 4$dİ2014 215 $a1 online resource (495 p.) 300 $aDescription based upon print version of record. 311 0 $a0-691-18067-9 311 0 $a0-691-15646-8 320 $aIncludes bibliographical references and index. 327 $tFront matter --$tContents --$tPreface --$tIntroduction: What This Book Aims to Do and What It Is Not --$tPart I. Concepts and Mechanisms --$tPart II. Paradigms and Research Programs --$tReferences --$tIndex 330 $aHomology-a similar trait shared by different species and derived from common ancestry, such as a seal's fin and a bird's wing-is one of the most fundamental yet challenging concepts in evolutionary biology. This groundbreaking book provides the first mechanistically based theory of what homology is and how it arises in evolution. Günter Wagner, one of the preeminent researchers in the field, argues that homology, or character identity, can be explained through the historical continuity of character identity networks-that is, the gene regulatory networks that enable differential gene expression. He shows how character identity is independent of the form and function of the character itself because the same network can activate different effector genes and thus control the development of different shapes, sizes, and qualities of the character. Demonstrating how this theoretical model can provide a foundation for understanding the evolutionary origin of novel characters, Wagner applies it to the origin and evolution of specific systems, such as cell types; skin, hair, and feathers; limbs and digits; and flowers. The first major synthesis of homology to be published in decades, Homology, Genes, and Evolutionary Innovation reveals how a mechanistically based theory can serve as a unifying concept for any branch of science concerned with the structure and development of organisms, and how it can help explain major transitions in evolution and broad patterns of biological diversity. 606 $aDevelopmental genetics 606 $aEvolution (Biology) 606 $aGenetic regulation 608 $aElectronic books. 615 0$aDevelopmental genetics. 615 0$aEvolution (Biology) 615 0$aGenetic regulation. 676 $a571.8/5 700 $aWagner$b Gu?nter P.$0352381 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910463928103321 996 $aHomology, genes, and evolutionary innovation$92458559 997 $aUNINA