LEADER 00835nam0 2200241 450 001 000024242 005 20090311111832.0 010 $a88-13-27081-X 100 $a20090311d2007----km-y0itay50------ba 101 0 $aita 102 $aIT 105 $ay-------001yy 200 1 $a<>reati societari$ecommentario aggiornato alla Legge 28 dicembre 2005 n. 262 sulla tutela del risparmio$fa cura di Alessio Lanzi e Alberto Cadoppi 210 $aPadova$cCedam$dc2007 215 $aX, 547 p.$d25 cm 500 10$a<>reati societari$959707 610 1 $aReati societari 676 $a345.450268$v19$9Reati di natura finanziaria, economica, professionale. Italia 801 0$aIT$bUNIPARTHENOPE$c20090311$gRICA$2UNIMARC 912 $a000024242 951 $a345-R/4$b41195$cNAVA1$d2009 996 $aReati societari$959707 997 $aUNIPARTHENOPE LEADER 03738nam 2200481 450 001 9910717369103321 005 20221025085117.0 035 $a(CKB)3710000000362763 035 $a(NjHacI)993710000000362763 035 $a(OCoLC)903315260$z(OCoLC)1117842648 035 $a(EXLCZ)993710000000362763 100 $a20221025d2013 uy 0 101 0 $aeng 135 $aur||||||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aAntimicrobial stewardship programs in inpatient settings $ea systematic review /$fGregory Filice [and eight others] 210 1$aWashington, D. C. :$cDepartment of Veterans Affairs (US),$d[2013] 210 4$dİ2013 215 $a1 online resource (v, 144 pages) $cillustrations 225 1 $aEvidence-based synthesis program 300 $a"Evidence-based synthesis program." 300 $a"September 2013." 320 $aIncludes bibliographical references. 330 3 $aIt is estimated that in 2009, more than 3 million kilograms of antimicrobials were administered to human patients in the United States. While the life-saving benefits of antimicrobials are indisputable, the consequences of use and misuse must also be considered. Major concerns related to the use of antimicrobials are increasing resistance, higher incidence of Clostridium difficile (C. difficile) infection (CDI) and increased healthcare costs (including costs related to adverse events associated with antimicrobial use). While much of the discussion focuses on overuse, there is also evidence of adverse outcomes associated with inadequate antimicrobial therapy. Antimicrobial stewardship programs (ASPs) are a focused effort by a health care system, a hospital, or a portion of a hospital (e.g., an intensive care unit) to optimize the use of antimicrobial agents. The goals of an ASP are to improve patient outcomes, reduce adverse consequences, reduce or prevent an increase in antimicrobial resistance, and deliver cost-effective therapy. The emphasis is on appropriate selection, dosing, route, and duration of antimicrobial therapy. The purpose of this review is to synthesize the evidence about the effectiveness of antimicrobial stewardship programs implemented in hospital settings. We focus on ASPs including one or more of the following components: prospective audit and feedback, formulary restriction, pre-authorization of prescriptions, guidelines for prescribing and/or modifying therapy, computerized decision support, or laboratory testing. The topic was nominated by Matthew Goetz, MD, Chief, Infectious Diseases, VA Greater Los Angeles Healthcare System, on behalf of the VA Antimicrobial Stewardship Task Force, and is intended to provide a summary of the evidence on inpatient antimicrobial stewardship programs to guide clinical practice and policy within the Veterans Healthcare System. 410 0$aEvidence-based synthesis program (Series) 517 $aAntimicrobial stewardship programs in inpatient settings 606 $aAnti-infective agents$xSide effects 607 $aUnited States$2fast 615 0$aAnti-infective agents$xSide effects. 676 $a615.792 700 $aFilice$b Gregory$01354251 712 02$aUnited States.$bDepartment of Veterans Affairs.$bHealth Services Research and Development Service, 712 02$aQuality Enhancement Research Initiative (U.S.) 712 02$aMinneapolis VA Health Care System (U.S.).$bVA Evidence Synthesis Program. 712 02$aEvidence-based Synthesis Program (U.S.) 801 0$bNjHacI 801 1$bNjHacl 906 $aBOOK 912 $a9910717369103321 996 $aAntimicrobial stewardship programs in inpatient settings$93314991 997 $aUNINA