LEADER 00856nam0 2200277 450 001 000022523 005 20090204115003.0 100 $a20090204d1984----km-y0itay50------ba 101 0 $aita 102 $aIT 105 $ay-------001yy 200 1 $aScelte pubbliche e gestione dei servizi pubblici$fNino Luciani 210 $aMilano$cAngeli$dc1984 215 $a117 p.$d22 cm 225 2 $aUniversità$v16 410 0$12001$aUniversità 500 10$aScelte pubbliche e gestione dei servizi pubblici$945627 610 1 $aServizi pubblici 610 1 $aAziende pubbliche$aGestione 676 $a363$v18 700 1$aLuciani,$bNino$4070$0112733 801 0$aIT$bUNIPARTHENOPE$c20090203$gRICA$2UNIMARC 912 $a000022523 951 $a326/62$b4565$cNAVA2$d2009 996 $aScelte pubbliche e gestione dei servizi pubblici$945627 997 $aUNIPARTHENOPE LEADER 04427nam 22007095 450 001 9910845489803321 005 20250808093347.0 010 $a9783031550225 010 $a3031550226 024 7 $a10.1007/978-3-031-55022-5 035 $a(MiAaPQ)EBC31230582 035 $a(Au-PeEL)EBL31230582 035 $a(DE-He213)978-3-031-55022-5 035 $a(CKB)31120757800041 035 $a(OCoLC)1428259932 035 $a(MiAaPQ)EBC31574236 035 $a(Au-PeEL)EBL31574236 035 $a(EXLCZ)9931120757800041 100 $a20240326d2024 u| 0 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aCellular and Molecular Aspects of Ageing /$fedited by Valquiria Bueno 205 $a1st ed. 2024. 210 1$aCham :$cSpringer Nature Switzerland :$cImprint: Springer,$d2024. 215 $a1 online resource (159 pages) 311 08$a9783031550218 311 08$a3031550218 320 $aIncludes bibliographical references. 327 $a1. Introduction: Daniela Frasca & Valquiria Bueno -- 2. Cellular Senescence: Laura Haynes -- 3. Genomic instability: Carlos López-Otín -- 4. Telomeres:Rodrigo do Tocantins C.S.Rodrigues -- 5. Epigenetic: Miriam Galvonas Jasiulionis -- 6. Proteostasis: Ana Maria Cuervo -- 7. Deregulated nutrient-sensing: Pedro Manoel M.M.Vieira -- 8. Mitochondria/Oxidative Stress: Tiago Rodrigues -- 9. Stem cell exhaustion: Michael D Milsom -- 10. Cell-to-cell communication: Ana O'Loghlen -- 11. Senescence-associated secretory phenotype (SASP): Janet M Lord. 330 $aEven though life expectancy increased in the last decades, ageing has been considered a strong risk factor for age-related diseases, disability and death. The further understanding of cellular and molecular aspects of ageing could predict the onset of diseases in advance, prevent functional decline and identify targets for interventions focused in healthy ageing. The hypothesis that organismal ageing and dysfunction is influenced by the accumulation of senescent cells had origin in Hayflick and Moorhead results from cultured human fibroblasts. It was shown that fibroblasts presented a limited capacity for proliferation reaching thus the state of irreversible growth arrest (replicative senescence). In 2011, van Deusen et al. showed that p16Ink4a accumulation was associated with premature ageing in a mouse model and the inactivation of the p16Ink4a gene mitigated the ageing phenotype. Thus, the cell cycle arrest due to the expression of p16Ink4a and p21CIP (cell cycle inhibitors) is the main characteristic of senescence. In addition to cellular senescence, the hallmarks of ageing include genomic instability, telomere shortening , epigenetic alterations, loss of proteostasis, deregulated nutrient-sensing, mitochondrial dysfunction, stem cell exhaustion, altered intercellular communication, and a pro-inflammatory senescence-associated secretory phenotype (SASP). In this book, researchers will comprehensively discuss relevant changes occurring at cellular and molecular levels (human and animal models) based on the hallmarks of ageing. The impact of lifestyle and benefits of physical activity and nutrition will be also discussed. Unravelling cellular and molecular aspects of ageing is crucial for the unanswered questions about ageing and for guiding interventions such as changes in lifestyle, senolytic (kills senescent cells), and senomorphic (interrupts deleterious intercellular communication) therapies. 606 $aMolecular biology 606 $aCytology 606 $aGenetics 606 $aImmunology 606 $aMedical sciences 606 $aMolecular Biology 606 $aCell Biology 606 $aGenetics and Genomics 606 $aImmunology 606 $aHealth Sciences 615 0$aMolecular biology. 615 0$aCytology. 615 0$aGenetics. 615 0$aImmunology. 615 0$aMedical sciences. 615 14$aMolecular Biology. 615 24$aCell Biology. 615 24$aGenetics and Genomics. 615 24$aImmunology. 615 24$aHealth Sciences. 676 $a612.67 702 $aBueno$b Valquiria 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910845489803321 996 $aCellular and Molecular Aspects of Ageing$94430289 997 $aUNINA