LEADER 00958nam0 2200301 450 001 000019899 005 20081216092153.0 010 $a0340190086 100 $a20081125d1978----km-y0itay50------ba 101 0 $aeng 102 $aGB 105 $ay-------001yy 200 1 $aFirst steps in numerical analysis$fR. J. Hosking, D. C. Joyce, J. C. Turner 210 $aLondon [etc.]$cHodder and Stoughton$d1978 215 $a202 p.$d21 cm 500 10$aFirst steps in numerical analysis$933579 517 1 $aNumerical analysis 610 1 $aAnalisi numerica 676 $a519.4$v20$9Analisi numerica applicata 700 1$aHosking,$bR. J.$0632461 701 1$aJoyce,$bD. C.$0632462 701 1$aTurner,$bJ. C.$016018 801 0$aIT$bUNIPARTHENOPE$c20081125$gRICA$2UNIMARC 912 $a000019899 951 $aM 519.4/34$bM 69$cDSA$d2008 951 $aG 511/4$bG 13$cDSA$d2008 996 $aFirst steps in numerical analysis$933579 997 $aUNIPARTHENOPE LEADER 00967nam0-22002891i-450- 001 990006194990403321 005 19980601 035 $a000619499 035 $aFED01000619499 035 $a(Aleph)000619499FED01 035 $a000619499 100 $a19980601d1960----km-y0itay50------ba 105 $a--------00-yy 200 1 $aInternationales Steuerrecht (I St R) und Internationales Privatrecht (I P R)$eein Systematischer Versuch$fOttmar Buhler. 210 $aAmsterdam$cInternationales Steuerdokumentationsburo$d1960 215 $a88 p.$d24 cm 225 1 $a"International Bureau of Fiscal Documentation. Publications$v13 676 $a341 700 1$aBühler,$bOttmar$0412202 801 0$aIT$bUNINA$gRICA$2UNIMARC 901 $aBK 912 $a990006194990403321 952 $aBUSTA 10 (6) 5$b64869$fFGBC 959 $aFGBC 996 $aInternationales Steuerrecht (I St R) und Internationales Privatrecht (I P R$9648956 997 $aUNINA DB $aGIU01 LEADER 03713nam 2200445z- 450 001 9910261146703321 005 20210212 035 $a(CKB)4100000002484625 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/59991 035 $a(oapen)doab59991 035 $a(EXLCZ)994100000002484625 100 $a20202102d2016 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aState-of-the-Art Research on C1q and the Classical Complement Pathway 210 $cFrontiers Media SA$d2016 215 $a1 online resource (100 p.) 225 1 $aFrontiers Research Topics 311 08$a2-88945-058-9 330 $aC1q is the target recognition protein of the classical complement pathway and a major connecting link between innate and acquired immunity. As a charge pattern recognition molecule of innate immunity, C1q can engage a broad range of ligands derived from self, non-self and altered self via its heterotrimeric globular (gC1q) domain and thus trigger the classical complement pathway. The trimeric gC1q signature domain has been identified in a variety of non-complement proteins that can be grouped together as a C1q family. C1q circulates in serum as part of the C1 complex, in association with a catalytic tetrameric assembly of two homologous yet distinct serine proteases, C1r and C1s. Binding of C1q to appropriate targets leads to sequential activation of C1r and C1s, the latter being able to cleave complement components C4 and C2 thereby triggering the complement cascade. Activation of the classical pathway plays an important role in innate immune protection against pathogens and damaged elements from self. However, its involvement has been shown in various pathologies including ischemia-reperfusion injury and hereditary angioedema. Unexpected roles for the classical pathway have also been discovered recently, linked to both physiological and pathological aspects of development, including brain and cancer cells. These new perspectives should arouse renewed interest in a search for specific inhibitors of the classical pathway. In addition, C1q has recently been shown to have a number of functions that are independent of the activation of the classical pathway. This research topic is aimed at providing a state-of-the-art overview of the classical pathway, including, but not restricted to emerging functions of C1q and of the C1 complex, as well as pathological consequences of C1 activation or of the presence of anti-C1q autoantibodies . Contributions are included in the areas such as structural basis of C1q ligand recognition, C1q family proteins, inhibitors of the classical pathway identified in pathogens and improved derived inhibitors, structural determinants of the substrate specificities of C1r and C1s, elucidation of the architecture of C1, structural and functional homology of C1 with the initiating complexes of the lectin complement pathway, and novel involvement of C1q in processes such as ageing, cancer, synaptic pruning, and pregnancy. 606 $aMedicine and Nursing$2bicssc 610 $aAutoimmunity 610 $aC1 complex 610 $ac1q 610 $aC1s 610 $aclassical pathway activation 610 $acomplement 610 $aemerging functions 610 $agC1q structure 615 7$aMedicine and Nursing 700 $aChristine Gaboriaud$4auth$01329298 702 $aNicole M. Thielens$4auth 702 $aUday Kishore$4auth 906 $aBOOK 912 $a9910261146703321 996 $aState-of-the-Art Research on C1q and the Classical Complement Pathway$93039398 997 $aUNINA