LEADER 00823nam0 2200301 450 001 000015161 005 20190107141434.0 100 $a20080804d1962----km-y0itay50------ba 101 0 $aita 102 $aIT 105 $ay-------001yy 200 1 $aManuale di diritto amministrativo$fAldo M. Sandulli 205 $a7. ed. 210 $aNapoli$cE. Jovene$d1962 215 $a773 p.$d24 cm 451 0$1001000001056 451 0$1001000015151 451 0$1001000015535 451 0$1001000017851 610 1 $aDiritto amministrativo 676 $a351.94$v19 676 $a342.45 700 1$aSandulli,$bAldo M.$033185 801 0$aIT$bUNIPARTHENOPE$c20080808$gRICA$2UNIMARC 912 $a000015161 951 $a351.94/101(2)$b15628$cNAVA4 996 $aManuale di diritto amministrativo$966239 997 $aUNIPARTHENOPE LEADER 01134nam 2200373 450 001 9910794141903321 005 20230822234005.0 010 $a1-83867-138-2 035 $a(CKB)4100000011135859 035 $a(MiAaPQ)EBC6183834 035 $a(EXLCZ)994100000011135859 100 $a20200806d2020 uy 0 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aAddressing student sexual violence in higher education $ea good practice guide /$fby Clarissa J. Humphreys, Graham J. Towl 210 1$aBingley, England :$cEmerald Publishing,$d[2020] 210 4$dİ2020 215 $a1 online resource (257 pages) 311 $a1-83867-141-2 606 $aSex crimes$xPrevention 615 0$aSex crimes$xPrevention. 676 $a362.88 700 $aHumphreys$b Clarissa J.$01518306 702 $aTowl$b Graham J. 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910794141903321 996 $aAddressing student sexual violence in higher education$93755794 997 $aUNINA LEADER 03342nam 2200517z- 450 001 9910345964003321 005 20210212 035 $a(CKB)4920000000094074 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/58603 035 $a(oapen)doab58603 035 $a(EXLCZ)994920000000094074 100 $a20202102d2018 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aRole of Protein-Protein Interactions in Metabolism: Genetics, Structure, Function 210 $cFrontiers Media SA$d2018 215 $a1 online resource (152 p.) 225 1 $aFrontiers Research Topics 311 08$a2-88945-385-5 330 $aGenetic variations may change the structure and function of individual proteins as well as affect their interactions with other proteins and thereby impact metabolic processes dependent on protein-protein interactions. For example, cytochrome P450 proteins, which metabolize a vast array of drugs, steroids and other xenobiotics, are dependent on interactions with redox and allosteric partner proteins for their localization, stability, (catalytic) function and metabolic diversity (reactions). Genetic variations may impact such interactions by changing the splicing and/or amino acid sequence which in turn may impact protein topology, localization, post translational modifications and three dimensional structure. More generally, research on single gene defects and their role in disease, as well as recent large scale sequencing studies suggest that a large number of genetic variations may contribute to disease not only by affecting gene function or expression but also by modulating complex protein interaction networks.The aim of this research topic is to bring together researchers working in the area of drug, steroid and xenobiotic metabolism who are studying protein-protein interactions, to describe their recent advances in the field. We are aiming for a comprehensive analysis of the subject from different approaches including genetics, proteomics, transcriptomics, structural biology, biochemistry and pharmacology. Of particular interest are papers dealing with translational research describing the role of novel genetic variations altering protein-protein interaction. Authors may submit original articles, reviews and opinion or hypothesis papers dealing with the role of protein-protein interactions in health and disease. 517 $aRole of Protein-Protein Interactions in Metabolism 606 $aPharmacology$2bicssc 610 $aBiocatalysis 610 $aCytochrome P450 610 $aDrug metabolism 610 $aMembrane-associated progesterone receptor 610 $aPharmacogenetics 610 $aPOR 610 $aPXR 610 $aSteroids 610 $aUDP-glucuronosyltransferase 610 $aUGT 615 7$aPharmacology 700 $aMichel Kranendonk$4auth$01281234 702 $aWayne L. Backes$4auth 702 $aUlrich M. Zanger$4auth 702 $aAmit V. Pandey$4auth 702 $aColin J. Henderson$4auth 702 $aYuji Ishii$4auth 906 $aBOOK 912 $a9910345964003321 996 $aRole of Protein-Protein Interactions in Metabolism: Genetics, Structure, Function$93018404 997 $aUNINA