LEADER 00753nam0 2200229 450 001 000011691 005 20181207115522.0 100 $a20080522d1949----km-y0itay50------ba 101 0 $aita 102 $aIT 105 $ay-------001yy 200 1 $a<>guida legale bancaria$e(ad uso degli Istituti di credito, degli avvocati, notai e per la preparazione ai concorsi bancari)$fGiovanni Verrei 210 $aNapoli$cTip. S. I. F. A. C.$d1949 215 $a[14], 96 p.$d22 cm 610 1 $aBanche$aDiritto 676 $a346.082$v18 700 1$aVerrei,$bGiovanni$0631330 801 0$aIT$bUNIPARTHENOPE$c20080522$gRICA$2UNIMARC 912 $a000011691 951 $a346.082/100$bs. i.$cNAVA4 996 $aGuida legale bancaria$91204300 997 $aUNIPARTHENOPE LEADER 03565nam 2200577 a 450 001 9910437807603321 005 20200520144314.0 010 $a1-299-19802-3 010 $a4-431-54231-0 024 7 $a10.1007/978-4-431-54231-5 035 $a(CKB)2670000000338071 035 $a(EBL)1106269 035 $a(OCoLC)827212112 035 $a(SSID)ssj0000878733 035 $a(PQKBManifestationID)11476027 035 $a(PQKBTitleCode)TC0000878733 035 $a(PQKBWorkID)10837179 035 $a(PQKB)11715896 035 $a(DE-He213)978-4-431-54231-5 035 $a(MiAaPQ)EBC1106269 035 $a(PPN)168332620 035 $a(EXLCZ)992670000000338071 100 $a20121212d2013 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aDevelopment of novel hydrogen-bond donor catalysts $edoctoral thesis accepted by Kyoto University, Japan /$fTsubasa Inokuma 205 $a1st ed. 2013. 210 $aNew York $cSpringer$d2013 215 $a1 online resource (118 p.) 225 1 $aSpringer theses : recognizing outstanding Ph.D. research,$x2190-5053 300 $aDescription based upon print version of record. 311 $a4-431-54745-2 311 $a4-431-54230-2 320 $aIncludes bibliographical references. 327 $aIntroduction -- Development of HB donor catalysts -- Development and properties of novel HB donor catalysts -- Asymmetric Michael addition to alpha,beta-unsaturated imides catalyzed by HB donors -- Asymmetric Hydrazination of activated methylene compounds catalyzed by HB donors -- Development of hydroxy thiourea catalysts -- Asymmetric Michael addition of gamma-hydroxyenones and alkenylboronic acids -- Asymmetric Petasis Reaction of N-aryl-alpha-iminoamides and Alkenylboronates -- Conclusion. 330 $aThis work describes novel, effective hydrogen-bond (HB) donor catalysts based on a known bifunctional tertiary amine-thiourea, a privileged structure, which has been proven to be one of the most widely used organocatalysts. These HB donor catalysts derived from quinazoline and benzothiadiazine were initially synthesized as novel HB donors with their HB-donating abilities being measured by analytical methods. They were found to be effective for a variety of asymmetric transformations including Michael reactions of a, b-unsaturated imides and hydrazination reactions of 1,3-dicarbonyl compounds. Thiourea catalysts that have an additional functional group are also described. Specifically, thioureas that bear a hydroxyl group were synthesized and subsequently used as novel bifunctional organocatalysts for catalytic, asymmetric Petasis-type reactions involving organoboronic acids as nucleophiles. These addition reactions were difficult to achieve using existing organocatalysts. One of the developed catalytic methods can be applied to the synthesis of biologically interesting peptide-derived compounds possessing unnatural vinyl glycine moieties. These findings introduce new criteria required for the development of organocatalysts for asymmetric reactions, thus making a significant contribution to the field of organocatalysis. 410 0$aSpringer theses. 606 $aHydrogen bonding 615 0$aHydrogen bonding. 676 $a547.215 700 $aInokuma$b Tsubasa$01060621 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910437807603321 996 $aDevelopment of Novel Hydrogen-Bond Donor Catalysts$92514657 997 $aUNINA