LEADER 03784nam 22006735 450 001 9910300183103321 005 20200701085207.0 010 $a3-319-12679-2 024 7 $a10.1007/978-3-319-12679-1 035 $a(CKB)3710000000315943 035 $a(EBL)1966000 035 $a(SSID)ssj0001408324 035 $a(PQKBManifestationID)11746697 035 $a(PQKBTitleCode)TC0001408324 035 $a(PQKBWorkID)11346665 035 $a(PQKB)10877915 035 $a(DE-He213)978-3-319-12679-1 035 $a(MiAaPQ)EBC1966000 035 $a(PPN)183153359 035 $a(EXLCZ)993710000000315943 100 $a20141211d2015 u| 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aNeuroanatomy and Pathology of Sporadic Alzheimer's Disease /$fby Heiko Braak, Kelly Del Tredici 205 $a1st ed. 2015. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2015. 215 $a1 online resource (168 p.) 225 1 $aAdvances in Anatomy, Embryology and Cell Biology,$x0301-5556 ;$v215 300 $a"With 48 figures." 311 $a3-319-12678-4 320 $aIncludes bibliographical references. 327 $aPrologue -- General Morphology of Alzheimer-associated intraneuronal pathology -- Consistent and systematic changes in the distribution pattern of intraneuronal inclusions render staging possible -- Basic organization of involved structures -- Presymptomatic stages -- General morphology of Alzheimer-associated extracellular pathology -- Symptomatic stages -- The progression of cortical lesions mimics the pattern of myelination in reverse order -- Tauopathies -- CSF biomarkers and imaging techniques -- The staging hypothesis: assumptions, challenges, potential -- Technical considerations.   . 330 $aAs indicated by its title, this monograph deals chiefly with morphologically recognizable deviations from the normal anatomical condition of the human CNS. The AD-associated pathology is illustrated from its beginnings (sometimes even in childhood) to its final form, which is reached late in life. The AD process commences much earlier than the clinically recognizable phase of the disorder, and its timeline includes an extended preclinical phase. The further the pendulum swings away from the symptomatic final stages towards the early pathology, the more obvious the lesions become, although from a standpoint of severity they are more unremarkable and thus frequently overlooked during routine neuropathological assessment. For this reason, the authors deal with the hallmark lesions in the early phases of the AD process in considerable detail. 410 0$aAdvances in Anatomy, Embryology and Cell Biology,$x0301-5556 ;$v215 606 $aNeurosciences 606 $aPathology 606 $aGeriatrics 606 $aNeurosciences$3https://scigraph.springernature.com/ontologies/product-market-codes/B18006 606 $aPathology$3https://scigraph.springernature.com/ontologies/product-market-codes/H4800X 606 $aGeriatrics/Gerontology$3https://scigraph.springernature.com/ontologies/product-market-codes/H33150 615 0$aNeurosciences. 615 0$aPathology. 615 0$aGeriatrics. 615 14$aNeurosciences. 615 24$aPathology. 615 24$aGeriatrics/Gerontology. 676 $a616.83107 700 $aBraak$b Heiko$4aut$4http://id.loc.gov/vocabulary/relators/aut$01058353 702 $aDel Tredici$b Kelly$4aut$4http://id.loc.gov/vocabulary/relators/aut 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910300183103321 996 $aNeuroanatomy and Pathology of Sporadic Alzheimer's Disease$92499521 997 $aUNINA LEADER 00979nam0 22002531i 450 001 UON00529892 005 20251124114602.813 100 $a20251124d1985 |0itac50 ba 101 $aita 102 $aIT 105 $a|||| ||||| 200 1 $aDizionario degli errori$eprontuario per correggere istantaneamente 4000 errori di italiano$fMauro Magni 210 $aMilano$cGiovanni De Vecchi Editore$d1985 215 $a414 p.$d21 cm. 606 $aLingua italiana$xErrori$xDizionario$3UONC105294$2FI 620 $aIT$dMilano$3UONL000005 700 1$aMagni$bMauro$3UONV298087$0252626 712 $aDe Vecchi$3UONV261837$4650 801 $aIT$bSOL$c20251128$gRICA 899 $aSIBA - SISTEMA BIBLIOTECARIO DI ATENEO$2UONSI 912 $aUON00529892 950 $aSIBA - SISTEMA BIBLIOTECARIO DI ATENEO$dSI B 0033 $eSI FP 1564 7 0033 $sBuono 996 $aDizionario degli errori$9822961 997 $aUNIOR