LEADER 01194nam a2200277 i 4500 001 991002185729707536 005 20020508191923.0 008 000223s1986 it ||| | ita 035 $ab10971798-39ule_inst 035 $aPARLA156904$9ExL 040 $aDip.to Scienze Storiche Fil. e Geogr.$bita 100 1 $aDel Boca, Angelo$0136788 245 13$aLa caduta dell'impero /$cAngelo Del Boca 260 $aRoma ; Bari :$bLaterza,$c1986 300 $a2 v. (XI, 618 p. compless.) ;$c21 cm. 440 4$aGli Italiani in Africa orientale BUL 490 0 $aBiblioteca universale Laterza ;$v186 651 4$aItalia$xPolitica coloniale 907 $a.b10971798$b23-02-17$c28-06-02 912 $a991002185729707536 945 $aLE009 STOR.65-136/V$g1$i2009000038653$lle009$o-$pE0.00$q-$rn$so $t0$u1$v0$w1$x0$y.i11082598$z28-06-02 945 $aLE009 STOR.65-136a$cV. 2$g1$i2009000038660$lle009$o-$pE0.00$q-$rn$so $t0$u1$v0$w1$x0$y.i11082604$z28-06-02 945 $aLE009 STOR.65-136/VI$cV. 2$g3$i2009000038677$lle009$o-$pE0.00$q-$rl$s- $t0$u1$v0$w1$x0$y.i11082616$z28-06-02 996 $aCaduta dell'impero$997777 997 $aUNISALENTO 998 $ale009$b01-01-00$cm$da $e-$fita$git $h3$i3 LEADER 03652oam 2200625I 450 001 9910800078703321 005 20230725051239.0 010 $a0-429-13666-8 010 $a1-283-27446-9 010 $a9786613274465 010 $a1-4398-1994-7 024 7 $a10.1201/b10714 035 $a(CKB)2550000000048814 035 $a(EBL)773634 035 $a(OCoLC)754582408 035 $a(SSID)ssj0000517107 035 $a(PQKBManifestationID)11318529 035 $a(PQKBTitleCode)TC0000517107 035 $a(PQKBWorkID)10478681 035 $a(PQKB)11377437 035 $a(MiAaPQ)EBC773634 035 $a(Au-PeEL)EBL773634 035 $a(CaPaEBR)ebr10495986 035 $a(CaONFJC)MIL327446 035 $a(EXLCZ)992550000000048814 100 $a20180331d2011 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aHandbook of analysis of oligonucleotides and related products /$fedited by Jose V. Bonilla, G. Susan Srivatsa 210 1$aBoca Raton, Fla. :$cCRC Press,$d2011. 215 $a1 online resource (502 p.) 300 $aDescription based upon print version of record. 311 $a1-4398-1993-9 320 $aIncludes bibliographical references and index. 327 $aFront Cover; Contents; Preface; Editors; Contributors; Introduction; Chapter 1: Purity Analysis and Impurities Determination by Reversed-Phase High-Performance Liquid Chromatography; Chapter 2: Purity Analysis and Impurities Determination by AEX-HPLC; Chapter 3: Purity Analysis and Molecular Weight Determination by Size Exclusion HPLC; Chapter 4: Analysis of Oligonucleotides by Liquid Chromatography and Mass Spectrometry; Chapter 6: Tm Analysis of Oligonucleotides; Chapter 7: Purity and Content Analysis of Oligonucleotides by Capillary Gel Electrophoresis 327 $aChapter 8: Bioanalysis of Therapeutic Oligonucleotides Using Hybridization-Based Immunoassay TechniquesChapter 9: Oligonucleotide Assay and Potency; Chapter 10: Microbial Analysis : Endotoxin Testing; Chapter 11: Analysis of Residual Solvents by Head Space Gas Chromatography; Chapter 12: Determination of Extinction Coefficient; Chapter 13: Structural Determination by NMR; Chapter 14: Infrared Analysis of Oligonucleotides; Chapter 15: Stability Indicating Methods for Oligonucleotide Products; Chapter 16: Analysis by Hydrophilic Interaction Chromatography 327 $aChapter 17: Determination of Base CompositionChapter 19: Regulatory Considerations for the Development of Oligonucleotide Therapeutics; Back Cover 330 $aOligonucleotides represent one of the most significant pharmaceutical breakthroughs in recent years, showing great promise as diagnostic and therapeutic agents for malignant tumors, cardiovascular disease, diabetes, viral infections, and many other degenerative disorders. The Handbook of Analysis of Oligonucleotides and Related Products is an essential reference manual on the practical application of modern and emerging analytical techniques for the analysis of this unique class of compounds. 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