LEADER 05745nam 2200817Ia 450 001 9910813135703321 005 20240516113421.0 010 $a9783527640003 010 $a3527640002 010 $a9781283869904 010 $a128386990X 010 $a9783527640010 010 $a3527640010 010 $a9783527639991 010 $a3527639993 035 $a(CKB)3340000000000196 035 $a(EBL)843677 035 $a(OCoLC)797919435 035 $a(SSID)ssj0000622277 035 $a(PQKBManifestationID)11392464 035 $a(PQKBTitleCode)TC0000622277 035 $a(PQKBWorkID)10637770 035 $a(PQKB)10335196 035 $a(MiAaPQ)EBC843677 035 $a(Au-PeEL)EBL843677 035 $a(CaPaEBR)ebr10577567 035 $a(CaONFJC)MIL418240 035 $a(PPN)194594017 035 $a(Perlego)1001425 035 $a(EXLCZ)993340000000000196 100 $a20110806d2012 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aGenome organization and function in the cell nucleus /$fedited by Karsten Rippe 205 $a1st ed. 210 $aHeidelberg, Germany $cWiley-VCH$dc2012 215 $a1 online resource (596 p.) 300 $aDescription based upon print version of record. 311 08$a9783527326983 311 08$a3527326987 320 $aIncludes bibliographical references and index. 327 $aGenome Organization and Function in the Cell Nucleus; Contents; Preface; List of Contributors; 1: Deciphering DNA Sequence Information; 1.1: Introduction; 1.2: Genes and Transcribed Regions; 1.2.1: Open Reading Frames; 1.2.2: Mapping Transcriptional Start Sites; 1.2.3: Mapping Untranslated Regions on mRNA; 1.3: Non-Coding Genomic Elements; 1.3.1: Pseudogenes; 1.3.2: Repeats; 1.3.3: Structural Variants; 1.3.4: Methods for SV Detection; 1.3.5: Transposons and Retrotransposons; 1.4: Regulatory Information; 1.4.1: Classes of Regulatory Elements; 1.4.2: Transcription Factor Binding Motifs 327 $a1.4.3: Allele-Specific Expression1.5: Individual Genetic Polymorphisms and Their Effect on Gene Expression; 1.6: Conclusion; 2: DNA Methylation; 2.1: Introduction; 2.1.1: Discovery of 5-Methylcytosine in DNA; 2.1.2: Epigenetic Control of Gene Expression; 2.2: Eukaryotic DNA Methyltransferases; 2.2.1: Dnmt1; 2.2.2: The Dnmt3 Family; 2.2.3: Cooperative Function of Dnmts; 2.3: Distribution of 5-Methylcytosine in the Mammalian Genome; 2.3.1: Spatial Distribution of 5-Methylcytosine; 2.3.2: CpG Islands and Promoter Regulation; 2.3.3: Repetitive DNA Sequences 327 $a2.3.4: Temporal Distribution of 5-Methylcytosine2.4: Control of Gene Expression by DNA Methylation; 2.4.1: Loss of Transcription Factor Binding; 2.4.2: Methyl-CpG Binding Proteins; 2.4.3: Interconnection of DNA Methylation with Other Epigenetic Pathways; 2.4.4: DNA Methylation, Higher Order Chromatin Structure, and Nuclear Architecture; 2.5: DNA Demethylation; 3: Nucleosomes as Control Elements for Accessing the Genome; 3.1: Introduction and Basic Terminology; 3.2: Nucleosomes are the Building Blocks of Chromatin; 3.2.1: Histones; 3.2.2: Protein DNA Interactions in the Nucleosome 327 $a3.2.3: The Structure of Nucleosomal DNA3.3: Nucleosomes Are Dynamic Macromolecular Assemblies; 3.3.1: Mechanisms to Promote Histone Exchange In Vivo; 3.3.2: In Vitro Determination of Nucleosome Stability; 3.4: Histone Variants and Their Effect on Nucleosome Structure and Dynamics; 3.4.1: Variant Nucleosome Structures; 3.5: Histone Modifications in Nucleosome and Chromatin Structure; 3.6: DNA Sequence and Nucleosome Positioning; 3.6.1: Mechanisms for Nucleosome Exclusion; 3.6.2: Features that Promote Nucleosome Formation; 3.7: Histone Chaperones and Chromatin Dynamics; 3.7.1: Transcription 327 $a3.7.2: DNA Replication3.7.3: DNA Repair; 3.7.4: Mechanism of Chaperone-Mediated Nucleosome Assembly and Disassembly; 3.8: Outlook and Concluding Remarks; 4: Histone Modifications and Their Role as Epigenetic Marks; 4.1: The Complexity of Histone Modifications; 4.2: Regulating Histone Modifications in Chromatin; 4.3: The ""Histone Code"" Hypothesis; 4.3.1: Defining Histone ""Marks."" Why Is Histone Modification so Complex?; 4.3.2: Recognizing Histone Modifications: ""Reader"" Domains; 4.4: Exploiting the Complexity of the Histone Code: ""Crosstalk"" Between Different Modifications 327 $a4.4.1: Histone ""Crosstalk"": Increased Code Complexity and Signal Integration 330 $aBy way of its clear and logical structure, as well as abundant highresolution illustrations, this is a systematic survey of the players and pathways that control genome function in the mammalian cell nucleus. As such, this handbook and reference ties together recently gainedknowledge from a variety of scientific disciplines and approaches, dissecting all major genomic events: transcription, replication, repair,recombination and chromosome segregation. A special emphasis is put on transcriptional control, including genome-wide interactions andnon-coding RNAs, chromatin structure, ep 606 $aMammals$xGenetics 606 $aGenomes 606 $aMolecular genetics 608 $aAufsatzsammlung. 608 $aAufsatzsammlung.$2gnd 615 0$aMammals$xGenetics. 615 0$aGenomes. 615 0$aMolecular genetics. 676 $a572.8619 686 $aWE 4000$2rvk 686 $a570$2sdnb 686 $aQU 350$2sdnb 701 $aRippe$b Karsten$01632846 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910813135703321 996 $aGenome organization and function in the cell nucleus$93972284 997 $aUNINA LEADER 01498nam0 22003371i 450 001 UON00493648 005 20231205105343.172 010 $a37-7201-296-5 100 $a20190327d1980 |0itac50 ba 101 $ager 102 $aDE 105 $a|||| ||||| 200 1 $aˆDie ‰italienische Literatur des Mittelalters$eDante, Petrarca, Boccaccio$fWilhelm Theodor Elwert 210 $aMünchen$cFrancke$d1980 215 $a292 p.$d19 cm. 316 $aDono Prof. Alberto Varvaro.$5IT-UONSI F. 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Varvaro0830 $eSI 28644 7 Dono Prof. Alberto Varvaro. 996 $aItalienische Literatur des Mittelalters$91548606 997 $aUNIOR LEADER 03164nam 22006135 450 001 9910484453303321 005 20251230061136.0 010 $a3-030-37497-1 024 7 $a10.1007/978-3-030-37497-6 035 $a(CKB)4100000009940118 035 $a(MiAaPQ)EBC5987663 035 $a(DE-He213)978-3-030-37497-6 035 $a(PPN)24376801X 035 $a(EXLCZ)994100000009940118 100 $a20191130d2020 u| 0 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aAdvances in Engineering Research and Application $eProceedings of the International Conference on Engineering Research and Applications, ICERA 2019 /$fedited by Kai-Uwe Sattler, Duy Cuong Nguyen, Ngoc Pi Vu, Banh Tien Long, Horst Puta 205 $a1st ed. 2020. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2020. 215 $a1 online resource (753 pages) 225 1 $aLecture Notes in Networks and Systems,$x2367-3389 ;$v104 311 08$a3-030-37496-3 320 $aIncludes bibliographical references and index. 330 $aThis proceedings volume gathers the outcomes of the International Conference on Engineering Research and Applications (ICERA 2019), which was held at Thai Nguyen University of Technology, Vietnam, on December 1?2, 2019 and provided an international forum for disseminating the latest theories and practices in engineering research and applications. The conference focused on original research work in a broad range of areas, including Mechanical Engineering, Materials and Mechanics of Materials, Mechatronics and Micromechatronics, Automotive Engineering, Electrical and Electronics Engineering, and Information and Communication Technology. 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