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Stati Uniti- Medio Oriente$v22 700 1$aPETERSEN$bTore T.$3UONV236635$0783282 712 $aSussex Academic Press$3UONV259077$4650 801 $aIT$bSOL$c20240220$gRICA 899 $aSIBA - SISTEMA BIBLIOTECARIO DI ATENEO$2UONSI 912 $aUON00480866 950 $aSIBA - SISTEMA BIBLIOTECARIO DI ATENEO$dSI IV POL A 2169 $eSI 23698 5 2169 $sBuono 951 $aSIBA - SISTEMA BIBLIOTECARIO DI ATENEO$bSI20171213 1J 20170913Inventariato su preventivo 996 $aAnglo-American policy toward the Persian Gulf, 1978-1985$91739966 997 $aUNIOR LEADER 04164nam 22007575 450 001 9910765489503321 005 20240119223855.0 010 $a981-15-8473-7 024 7 $a10.1007/978-981-15-8473-2 035 $a(MiAaPQ)EBC30960497 035 $a(Au-PeEL)EBL30960497 035 $a(DE-He213)978-981-15-8473-2 035 $a(CKB)29019344600041 035 $a(EXLCZ)9929019344600041 100 $a20231120d2023 u| 0 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aRole of Signaling Pathways in Brain Tumorigenesis /$fby Mehdi Hayat Shahi 205 $a1st ed. 2023. 210 1$aSingapore :$cSpringer Nature Singapore :$cImprint: Springer,$d2023. 215 $a1 online resource (215 pages) 311 08$aPrint version: Shahi, Mehdi Hayat Role of Signaling Pathways in Brain Tumorigenesis Singapore : Springer,c2024 327 $aIntroduction of Cell signalling Pathways and Brain Tumours -- Wnt cell signalling pathway and brain tumours development -- Notch cell signalling pathway and Brain Tumours -- Shh cell signalling pathway and paediatric brain tumour ?Medulloblastoma? -- Role of Shh cell signalling pathway in ?glioma? -- Role of stem cell marker NANOG in brain tumours development -- Stem cell factor Sox2 and Brain Tumours Development -- Role of Neurotrophins in brain tumor development -- Role of NFk? in brain tumour development -- Role of Myc in brain tumours development -- Role of P53 in Medulloblastoma Development -- Role of Gene TP53 in glioblastoma development -- Role of HIF-1 in Brain Tumour Development -- EGFR and its role in glioma development -- Role of EFGR in medulloblastoma development -- Role of OCT4 in glioblastoma development -- Role of OCT4 in paediatric brain tumour ?medulloblastoma? development -- Role of Mitogen activated protein (MAP) Kinase in paediatric brain tumour ?medulloblastoma?. 330 $aThis book provides acomprehensive overview of cell signalling pathways and morphogens in the genesis of brain tumours. It also explains the role of brain tumour stem cells in the brain tumour progression. It also elucidates the novel early biomarkers that can be utilized to diagnose brain tumours. It presents the basic developmental pathways and morphogens, including retinoic acid and TGF-b that promote brain tumorigenesis. The chapters illustrate the role of stem cells and stem cells mediated cell signalling pathways including, Sonic hedgehog, Notch, Wnt in the brain tumour growth. The chapters also emphasize the role of transcription factors, mainlyNanog, Sox, BMI1, HIF1 and Pax6 in the brain tumouriogensis. It highlights the role of NF-kb, Myc and neurotrophins in the brain tumour development. 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