LEADER 00642nac# 22001811i 450 001 UON00408026 005 20231205104727.770 100 $a20120405f |0itac50 ba 102 $aIT 105 $a|||| ||||| 110 $ab|||||||||| 200 1 $a Guide Didattiche per la nuova scuola media 210 $aBrescia$cLa Scuola Editrice. 463 1$1001UON00408025$12001 $a Didattica della storia e dell'educazione civica$fG. Penati - E. Ziglioli$1210 $aBrescia$cLa Scuola Editrice$d1967 p. ; 20m cm. 801 $aIT$bSOL$c20240220$gRICA 912 $aUON00408026 996 $aGuide Didattiche per la nuova scuola media$93890452 997 $aUNIOR LEADER 04031nam 22010093a 450 001 9910367567503321 005 20250203235425.0 010 $a9783039212446 010 $a3039212443 024 8 $a10.3390/books978-3-03921-244-6 035 $a(CKB)4100000010106071 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/48248 035 $a(ScCtBLL)eb1e8a42-0797-4270-a119-8156881d0cff 035 $a(OCoLC)1163834607 035 $a(oapen)doab48248 035 $a(EXLCZ)994100000010106071 100 $a20250203i20192019 uu 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aG-quadruplex and Microorganisms$fSara N. Richter 210 $cMDPI - Multidisciplinary Digital Publishing Institute$d2019 210 1$aBasel, Switzerland :$cMDPI,$d2019. 215 $a1 electronic resource (208 p.) 311 08$a9783039212439 311 08$a3039212435 330 $aG-quadruplexes (G4s) are nucleic acids secondary structures that form in DNA or RNA guanine (G)-rich strands. In recent years, the presence of G4s in microorganisms has attracted increasing interest. In prokaryotes, G4 sequences have been reported in several human pathogens. Bacterial enzymes able to process G4s have been identified. In viruses, G4s have been suggested to be involved in key steps of the viral life cycle: They have been associated with the human immunodeficiency virus (HIV), herpes simplex virus 1 (HSV-1), human papilloma virus, swine pseudorabies virus, and other viruses' genomes. New evidence shows the presence of G4s in parasitic protozoa, such as the causative agent of malaria. G4 binding proteins and mRNA G4s have been implicated in the regulation of microorganisms' genome replication and translation. G4 ligands have been developed and tested both as tools to study the complexity of G4-mediated mechanisms in the viral life cycle and as therapeutic agents. Moreover, new techniques to study G4 folding and their interactions with proteins have been developed. 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The 27 papers presented in this volume were carefully reviewed and selected from a total of 73 submissions. 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