LEADER 03041nam 2200601 450 001 9910484381203321 005 20240124234403.0 010 $a981-336-613-3 024 7 $a10.1007/978-981-33-6613-8 035 $a(CKB)4100000011743155 035 $a(DE-He213)978-981-33-6613-8 035 $a(MiAaPQ)EBC6463810 035 $a(PPN)253250927 035 $a(EXLCZ)994100000011743155 100 $a20210405d2021 uy 0 101 0 $aeng 135 $aurnn#008mamaa 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aDevelopment of in-tether carbon chiral center-induced helical peptide $emethodology and applications /$fKuan Hu 205 $a1st ed. 2021. 210 1$aSingapore :$cSpringer,$d[2021] 210 4$dİ2021 215 $a1 online resource (XV, 102 p. 75 illus., 65 illus. in color.) 225 1 $aSpringer Theses 311 $a981-336-612-5 327 $aIntroduction -- Method to construct in-tether chiral center constrained helical peptide -- Application in disrupting p53/MDM2 protein-protein interactions -- Fabrication of nanomaterials with in-tether chiral center constrained helical peptide. 330 $aThis book focuses on the development of stapled peptides, a novel molecular modality used to regulate aberrant intracellular protein?protein interactions (PPIs). The author designs and presents a novel helical peptide stabilization methodology by constructing a chiral cross-linker moiety, namely ?chiral center induced peptide helicity (CIH)?. The book demonstrates that a precisely positioned carbon chiral center on tether can decisively determine the secondary structure of a peptide, and that the R-configured peptide is helical, while the S-configured peptide is non-helical. Further, it reports that helicity-enhanced R isomer peptides displayed significantly enhanced cell permeability and target binding affinity, as well as tumor inhibition efficiency, in comparison to S isomer peptides. The book will not only advance readers? understanding of the basic principle of stapled peptides, but also accelerate the clinical transformation of stapled peptide drugs. . 410 0$aSpringer theses. 606 $aPeptides$xSynthesis 606 $aCancer$xResearch 606 $aPeptides$xBiotechnology 606 $aChemistry Techniques, Synthetic 606 $aPeptides$xtherapeutic use 606 $aPeptides, Cyclic 606 $aBiomedical Research 615 0$aPeptides$xSynthesis. 615 0$aCancer$xResearch. 615 0$aPeptides$xBiotechnology. 615 2$aChemistry Techniques, Synthetic. 615 2$aPeptides$xtherapeutic use. 615 2$aPeptides, Cyclic. 615 2$aBiomedical Research. 676 $a547.756 700 $aHu$b Kuan$01223385 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910484381203321 996 $aDevelopment of In-Tether Carbon Chiral Center-Induced Helical Peptide$92837879 997 $aUNINA LEADER 01794nam 2200397z- 450 001 9910585995003321 005 20220803 035 $a(CKB)5590000000936506 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/90650 035 $a(oapen)doab90650 035 $a(EXLCZ)995590000000936506 100 $a20202208d2022 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aWorked to the Bone$eA Study of Gilded-Age Transatlantic Scientific Networks in Paleontology 210 $aHamburg$cHamburg University Press$d2022 215 $a1 online resource (434 p.) 311 08$a3-943423-95-6 330 $aIn the American "Wild West" the nation's predominant paleontologists O. C. Marsh and E. D. Cope raced for the discovery of the most spectacular dinosaur fossils the world had ever seen. The "Bone Wars" not only unearthed triceratops, stegosaurus, and brontosaurus, they also made US paleontology world-famous. This book analyzes international scientific networks, carves out German influences on the evolution of US paleontology and higher education, and examines the link between the rise of US nationalism and science. So-far neglected by scholars, the perspectives of O. C. Marsh's German assistants take center stage. 517 $aWorked to the Bone 606 $aLiterary theory$2bicssc 610 $a1860-1900 610 $aCultural history 610 $aGilded Age 610 $aHistory of knowledge 610 $aHistory of paleontology 610 $aUSA 615 7$aLiterary theory 700 $aWendler$b Philipp$4auth$01278274 906 $aBOOK 912 $a9910585995003321 996 $aWorked to the Bone$93013003 997 $aUNINA LEADER 01203nam0 22002891i 450 001 UON00406505 005 20231205104721.2 100 $a20120308d1960 |0itac50 ba 101 $apol 102 $aPL 105 $a|||| 1|||| 200 1 $aNauka jezyka polskiego we Wroclawiu (koniec wieku 16 205 $apolowa wieku 17.)$fAleksander Rombowski 210 $aWroclaw$cOssolineum$d1960 215 $a279 p., 4 c. di tav.$d25 cm. 410 1$1001UON00406506$12001 $aMonografie slaskie Ossolineum$fpod redakcja Jozefa Gierowskiego. Wroclaw$eOssolineum, 19xx- $1210 $av.$acm.$v1 606 $aLingua polacca$xStudi$3UONC079882$2FI 620 $aPL$dWroc?aw$3UONL003154 676 $a491.85$cLINGUA POLACCA$v21 700 1$aROMBOWSKI$bAleksander$3UONV208207$0708062 712 $aOssolineum$3UONV261461$4650 801 $aIT$bSOL$c20250912$gRICA 899 $aSIBA - SISTEMA BIBLIOTECARIO DI ATENEO$2UONSI 912 $aUON00406505 950 $aSIBA - SISTEMA BIBLIOTECARIO DI ATENEO$dSI FL 31 0007 $eSI SL 1816 5 0007 $sBuono 996 $aNauka jezyka polskiego we Wroclawiu (koniec wieku 16$91345921 997 $aUNIOR