LEADER 00873nam0 22002531i 450 001 UON00342749 005 20231205104304.947 100 $a20091103d1949 |0itac50 ba 101 $ager 102 $aDE 105 $a|||| 1|||| 200 1 $aˆDer ‰Henker$eRoman$fEdzard Schaper 210 $aZürich$cAtlantis$d1949 215 $a765 p.$d20 cm. 620 $aCH$dZürich$3UONL003145 676 $a833$cLetteratura narrativa tedesca$v21 700 1$aSCHAPER$bEdzard$3UONV192258$0132174 712 $aAtlantis$3UONV250332$4650 801 $aIT$bSOL$c20240220$gRICA 899 $aSIBA - SISTEMA BIBLIOTECARIO DI ATENEO$2UONSI 912 $aUON00342749 950 $aSIBA - SISTEMA BIBLIOTECARIO DI ATENEO$dSI TED 25 I SCHA 03 $eSI ST 5491 5 03 996 $aHenker$91361433 997 $aUNIOR LEADER 03497nam 22004935 450 001 9910300451903321 005 20251116191253.0 010 $a981-10-5336-7 024 7 $a10.1007/978-981-10-5336-8 035 $a(CKB)4100000000587413 035 $a(DE-He213)978-981-10-5336-8 035 $a(MiAaPQ)EBC5049902 035 $a(PPN)204532019 035 $a(EXLCZ)994100000000587413 100 $a20170918d2018 u| 0 101 0 $aeng 135 $aurnn#008mamaa 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aAntibiotic Pharmacokinetic/Pharmacodynamic Considerations in the Critically Ill /$fedited by Andrew A. Udy, Jason A. Roberts, Jeffrey Lipman 205 $a1st ed. 2018. 210 1$aSingapore :$cSpringer Singapore :$cImprint: Adis,$d2018. 215 $a1 online resource (X, 275 p. 22 illus., 9 illus. in color.) 311 08$a981-10-5335-9 320 $aIncludes bibliographical references. 327 $a1. Basic Pharmacokinetic Principles -- 2. Antibiotic Pharmacodynamics -- 3. Physiological Manifestations of Critical Illness -- 4. Dosing in Obese Critically Ill Patients -- 5. Hypoalbuminemia and Altered Protein Binding -- 6. Antibacterial Pharmacokinetic/Pharmacodynamic Considerations in the Critically ill -- 7. Augmented Renal Clearance -- 8. Antibiotic Dosing During Extracorporeal Membrane Oxygenation -- 9. Therapeutic Drug Monitoring: More than Avoiding Toxicity -- 10. Generic and Optimised Antibacterial Dosing Strategies in the Critically Ill -- 11. Antifungal PK/PD in the Critically Ill -- 12. Antibiotic Dosing in Pediatric Critically Ill Patients -- 13. Antibiotic Stewardship in the Intensive Care Unit. 330 $aThis book provides unique insights into the issues that drive modified dosing regimens for antibiotics in the critically ill. Leading international authors provide their commentary alongside a summary of existing evidence on how to effectively dose antibiotics. Severe infection frequently necessitates admission to the intensive care unit (ICU). Equally, nosocomial sepsis often complicates the clinical course in ICU.  Early, appropriate application of antibiotic therapy remains a cornerstone of effective management. However, this is challenging in the critical care environment, given the significant changes in patient physiology and organ function frequently encountered. Being cognisant of these factors, prescribers need to consider modified dosing regimens, not only to ensure adequate drug exposure, and therefore the greatest chance of clinical cure, but also to avoid encouraging drug resistance. 606 $aChemotherapy 606 $aPharmaceutical technology 606 $aPharmacotherapy$3https://scigraph.springernature.com/ontologies/product-market-codes/H69000 606 $aPharmaceutical Sciences/Technology$3https://scigraph.springernature.com/ontologies/product-market-codes/B21010 615 0$aChemotherapy. 615 0$aPharmaceutical technology. 615 14$aPharmacotherapy. 615 24$aPharmaceutical Sciences/Technology. 676 $a615.1 702 $aUdy$b Andrew A.$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aRoberts$b Jason A$g(Jason Alexander),$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aLipman$b Jeffrey$4edt$4http://id.loc.gov/vocabulary/relators/edt 906 $aBOOK 912 $a9910300451903321 996 $aAntibiotic Pharmacokinetic$91963855 997 $aUNINA