LEADER 01073nam0 22002771i 450 001 UON00326256 005 20231205104201.483 100 $a20090713d1984 |0itac50 ba 101 $apor 102 $aBR 105 $a|||| ||||| 200 1 $aCadeira de balanço$ecronicas$fCarlos Drummond de Andrade$gestudo da Angela Vaz Leao 205 $a15a ed 210 $aRio de Janeiro$cLivraria José Olympio Editora$d1984 215 $a157 p.$d21 cm. 606 $aLetteratura brasiliana$xNarrativa$3UONC042279$2FI 620 $aBR$dRio de Janeiro$3UONL001554 676 $a969$cIsole dell'oceano Indiano meridionale$v21 700 1$aANDRADE$bCarlos Drummond de$3UONV122428$0601449 712 $aJosé Olympio$3UONV275444$4650 801 $aIT$bSOL$c20251107$gRICA 899 $aSIBA - SISTEMA BIBLIOTECARIO DI ATENEO$2UONSI 912 $aUON00326256 950 $aSIBA - SISTEMA BIBLIOTECARIO DI ATENEO$dSI III 0637 $eSI LO 48818 5 0637 996 $aCadeira de balanço$91369330 997 $aUNIOR LEADER 04361nam 22006975 450 001 9910298585703321 005 20200702042534.0 010 $a3-319-77706-8 024 7 $a10.1007/978-3-319-77706-1 035 $a(CKB)4100000004243814 035 $a(DE-He213)978-3-319-77706-1 035 $a(MiAaPQ)EBC5404503 035 $a(PPN)227399323 035 $a(EXLCZ)994100000004243814 100 $a20180528d2018 u| 0 101 0 $aeng 135 $aurnn|008mamaa 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aCarbohydrate-Based Interactions at the Molecular and the Cellular Level /$fby Kieran L. Hudson 205 $a1st ed. 2018. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2018. 215 $a1 online resource (XXIX, 198 p. 98 illus., 49 illus. in color.) 225 1 $aSpringer Theses, Recognizing Outstanding Ph.D. Research,$x2190-5053 311 $a3-319-77705-X 327 $aIntroduction -- Protein-Carbohydrate Interactions in Protein X-ray Crystal Structures -- The Nature of Protein-Carbohydrate Interactions -- The Modifiable Scaffold for Tissue Engineering -- Carbohydrate Modifiers for Tissue Engineering Scaffolds -- Conclusions and Future Directions -- Experimental Details and Supplementary Data. 330 $aThis book offers a clearly written and highly accessible account of two different aspects of carbohydrate chemistry. Carbohydrates are an essential component of life and have many important biological functions, but the details of how carbohydrates interact with other biomolecules to mediate biological signalling remain unclear. Firstly, this thesis details innovative methods to mine protein structural data to uncover new features of carbohydrate-based interactions. It also explains these findings using physical chemistry, specifically CH?pi interactions associated with the properties of the interacting partners. Carbohydrates are also critical for tissue growth and development, yet are underexploited in the materials science that underpins much of regenerative medicine. As such, the second part of this thesis describes a diverse array of techniques ranging from synthetic chemistry and enzymatic synthesis to prepare a wide variety of carbohydrates, and materials chemistry to prepare glycosylated hydrogels, to cell biology to determine the effects on cellular development for tissue engineering applications. 410 0$aSpringer Theses, Recognizing Outstanding Ph.D. Research,$x2190-5053 606 $aCarbohydrates 606 $aProteins 606 $aChemistry, Physical and theoretical 606 $aRegenerative medicine 606 $aTissue engineering 606 $aChemistry, Physical and theoretical 606 $aAnalytical chemistry 606 $aCarbohydrate Chemistry$3https://scigraph.springernature.com/ontologies/product-market-codes/C19030 606 $aProtein-Ligand Interactions$3https://scigraph.springernature.com/ontologies/product-market-codes/L14060 606 $aTheoretical and Computational Chemistry$3https://scigraph.springernature.com/ontologies/product-market-codes/C25007 606 $aRegenerative Medicine/Tissue Engineering$3https://scigraph.springernature.com/ontologies/product-market-codes/L16080 606 $aPhysical Chemistry$3https://scigraph.springernature.com/ontologies/product-market-codes/C21001 606 $aAnalytical Chemistry$3https://scigraph.springernature.com/ontologies/product-market-codes/C11006 615 0$aCarbohydrates. 615 0$aProteins. 615 0$aChemistry, Physical and theoretical. 615 0$aRegenerative medicine. 615 0$aTissue engineering. 615 0$aChemistry, Physical and theoretical. 615 0$aAnalytical chemistry. 615 14$aCarbohydrate Chemistry. 615 24$aProtein-Ligand Interactions. 615 24$aTheoretical and Computational Chemistry. 615 24$aRegenerative Medicine/Tissue Engineering. 615 24$aPhysical Chemistry. 615 24$aAnalytical Chemistry. 676 $a547.78 700 $aHudson$b Kieran L$4aut$4http://id.loc.gov/vocabulary/relators/aut$0768763 906 $aBOOK 912 $a9910298585703321 996 $aCarbohydrate-Based Interactions at the Molecular and the Cellular Level$91566608 997 $aUNINA