LEADER 01116nam0 22002771i 450 001 UON00306080 005 20231205104032.714 100 $a20080108d1964 |0itac50 ba 101 $ajpn$aENG 102 $aJP 105 $a|||| 1|||| 200 1 $aAinu-go hogen jiten$dAn ainu dialect dictionary with Ainu, Japanese and English indexes$fHattori Shiro hen 210 $aTokyo$cIwanami Shoten$d1964 215 $a556 p.$d27 cm 510 1$3UON00377499$aˆAn ‰Ainu dialect dictionary with Ainu, Japanese and English indexes 606 $aLINGUA GIAPPONESE$xAINU$3UONC000492$2FI 620 $aJP$dTo?kyo?$3UONL000031 686 $aGIA II D$cGIAPPONE - DIALETTOLOGIA$2A 702 0$aHATTORI Shiro$3UONV009521 712 $aIwanami shoten$3UONV246463$4650 801 $aIT$bSOL$c20240220$gRICA 899 $aSIBA - SISTEMA BIBLIOTECARIO DI ATENEO$2UONSI 912 $aUON00306080 950 $aSIBA - SISTEMA BIBLIOTECARIO DI ATENEO$dSI GIA II D 014 $eSI MR 81014 7 014 996 $aAinu-go hogen jiten$91378077 997 $aUNIOR LEADER 02715nam 2200373 n 450 001 9910598192603321 005 20230221100949.0 035 $a(CKB)4920000000095212 035 $a(NjHacI)994920000000095212 035 $a(EXLCZ)994920000000095212 100 $a20230221d2018 uy 0 101 0 $aeng 135 $aur||||||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aCyclic nucleotide signaling and the cardiovascular system /$fedited by Thomas Brand and Enno Klussmann 210 1$aBasel, Switzerland :$cMDPI - Multidisciplinary Digital Publishing Institute,$d[2018] 210 4$d©2018 215 $a1 online resource (306 pages) $cillustrations 311 $a3-03842-989-9 320 $aIncludes bibliographical references. 330 $aThe cyclic nucleotides 3',5'-adenosine monophosphate (cAMP) and 3',5'-cyclic guanosine monophosphate (cGMP) play important roles in the control of cardiovascular function under physiological and pathological conditions. In this book, which is a reprint of a Special Issue of the Journal of Cardiovascular Development and Disease entitled "Cyclic Nucleotide Signaling and the Cardiovascular System", internationally recognized experts give an overview of this vibrant scientific field. The first series of articles deal with the localization and function of membrane-bound and soluble adenylate cyclases, followed by articles on the roles of phosphodiesterase isoforms in the heart. Cyclic nucleotide signaling takes place in nanodomains and the A-kinase anchor proteins (AKAPS) are essential for the compartmentalized assembly of signaling proteins into functional complexes. Reviews on the role of AKAP proteins in the physiology and pathophysiology of the heart are also included in this book. Cyclic nucleotides act through effector proteins and articles on EPAC and POPDC proteins inform the reader of recent developments on these topics. A major advancement in our understanding of cyclic nucleotide signaling came through the use of genetically encoded cAMP sensor molecules, and a series of articles review the current insight that these reporter molecules have provided. The final set of articles in this book deals with the association of the cyclic nucleotide pathway and cardiovascular disease as well as the development of novel therapeutic approaches. 606 $aNucleotides 615 0$aNucleotides. 676 $a547.79 702 $aBrand$b Thomas 702 $aKlussmann$b Enno 801 0$bNjHacI 801 1$bNjHacl 906 $aBOOK 912 $a9910598192603321 996 $aCyclic Nucleotide Signaling and the Cardiovascular System$92943092 997 $aUNINA