LEADER 00890nam0 22002531i 450 001 UON00297750 005 20231205103949.928 010 $a97-346-0238-1 100 $a20070625d2006 |0itac50 ba 101 $arom 102 $aRO 105 $a|||| 1|||| 200 1 $aPostmodernismul in antropologia culturiala$fGabriel Troc 210 $aIasi$cPolirom$d2006 215 $a355 p.$d20 cm. 620 $dIa?i$3UONL004069 700 1$aTROC$bGabriel$3UONV173644$0695210 712 $aPolirom$3UONV272593$4650 801 $aIT$bSOL$c20240220$gRICA 899 $aSIBA - SISTEMA BIBLIOTECARIO DI ATENEO$2UONSI 912 $aUON00297750 950 $aSIBA - SISTEMA BIBLIOTECARIO DI ATENEO$dSI ROMENO C 0014 $eSI EO 40110 7 0014 996 $aPostmodernismul in antropologia culturiala$91380132 997 $aUNIOR LEADER 04581nam 2201297z- 450 001 9910557105803321 005 20210501 035 $a(CKB)5400000000040989 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/68966 035 $a(oapen)doab68966 035 $a(EXLCZ)995400000000040989 100 $a20202105d2020 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aMetastatic Progression and Tumour Heterogeneity 210 $aBasel, Switzerland$cMDPI - Multidisciplinary Digital Publishing Institute$d2020 215 $a1 online resource (312 p.) 311 08$a3-03928-853-9 311 08$a3-03928-854-7 330 $aImproved understanding of the cellular and molecular makeup of tumors in the last 30 years has unraveled a previously unexpected level of heterogeneity among tumor cells as well as within the tumor microenvironment. The concept of tumor heterogeneity underlines the realization that different tumors can display significant differences in their genomic content as well as in their overall behavior. Our capacity to better understand the heterogeneous make up of tumors has very important consequences on our ability to design efficient therapeutic strategies to improve patient survival. This book highlights several aspects of tumor heterogeneity in the context of metastatic development and summarize some of the challenges posed by heterogeneity for tumor diagnostics and therapeutic management of tumors. 606 $aMedicine and Nursing$2bicssc 610 $a3D cultures 610 $aacidosis 610 $aADH 610 $aangiocrine factor 610 $abeta-catenin paradox 610 $abiomechanics 610 $abreast cancer 610 $acarbonic anhydrase 610 $acell fate 610 $acellular heterogeneity 610 $acirculating tumor cells 610 $acirculating tumor cells (CTCs) 610 $aclear cell renal cell carcinoma 610 $aclonality 610 $acollective and single-cell migration 610 $acolon cancer 610 $acolorectal cancer 610 $aCTC-clusters 610 $aDCIS 610 $adeficient mismatch repair 610 $aEMT 610 $aendometrial carcinoma 610 $aepigenetics 610 $aepithelial mesenchymal plasticity 610 $aepithelial-to-mesenchymal transition 610 $aesophageal squamous cell carcinoma 610 $aextracellular vesicles 610 $agene expression 610 $agenomics 610 $aheterogeneity 610 $ahybrid E/M 610 $ahyperpolarized 13C MRI 610 $aimmune checkpoints 610 $aimmune microenvironment 610 $aimmunotherapy 610 $ainterstitial pH 610 $aintra-tumour heterogeneity 610 $aintratumor heterogeneity 610 $alactic acid 610 $amagnetic resonance imaging 610 $amammary gland 610 $ametaplastic carcinoma 610 $ametastasis 610 $ametastatic niche 610 $amicrosatellite instability 610 $amiRNA expression 610 $amultisite tumor sampling 610 $amutation 610 $anatural killer cells 610 $anuclear medicine 610 $aorganoids 610 $apancreatic cancer 610 $aPET 610 $aphenotypic plasticity 610 $aPI3K/AKT pathway 610 $aplasticity 610 $apositron emission tomography 610 $aprecision medicine 610 $aradiomics 610 $aradiopharmaceuticals 610 $areview 610 $asignaling 610 $asingle-cell analysis 610 $asingle-cell RNAseq 610 $asubclonal diversity 610 $aSUV 610 $atarget discovery 610 $atargeted therapy 610 $aTP53 610 $atreatment resistance 610 $atumor ecology 610 $atumor endothelial cell 610 $atumor evolution 610 $atumor heterogeneity 610 $atumor microenvironment 610 $atumor mutation burden 610 $auterine carcinosarcoma 610 $aWnt signaling 615 7$aMedicine and Nursing 700 $aHollande$b Fred$4edt$01327820 702 $aMerino$b Delphine$4edt 702 $aHollande$b Fred$4oth 702 $aMerino$b Delphine$4oth 906 $aBOOK 912 $a9910557105803321 996 $aMetastatic Progression and Tumour Heterogeneity$93038137 997 $aUNINA