LEADER 00800nam0-22002891i-450- 001 990000852390403321 005 20001010 035 $a000085239 035 $aFED01000085239 035 $a(Aleph)000085239FED01 035 $a000085239 100 $a20001010d--------km-y0itay50------ba 101 0 $aita 105 $ay-------001yy 200 1 $a<>comprehensive introduction to differential geometry 205 $a2.ed. 210 $as.l.$cPublish or Perich Inc. Berke ley$d1979. 300 $aVol. IV 700 1$aSpivak,$bMichael$042072 801 0$aIT$bUNINA$gRICA$2UNIMARC 901 $aBK 912 $a990000852390403321 952 $a000085239000001$fFINBN 959 $aFINBN 996 $aComprehensive introduction to differential geometry$9186816 997 $aUNINA DB $aING01 LEADER 04462nam 2200637 450 001 9910131532103321 005 20230621140410.0 010 $a9782889192380$b(ebook) 035 $a(CKB)3710000000504556 035 $a(SSID)ssj0001680347 035 $a(PQKBManifestationID)16496203 035 $a(PQKBTitleCode)TC0001680347 035 $a(PQKBWorkID)15028422 035 $a(PQKB)10111740 035 $a(WaSeSS)IndRDA00056339 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/53528 035 $a(EXLCZ)993710000000504556 100 $a20160829d2014 uy 0 101 0 $aeng 135 $aur||#|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aMind the gap! $egap junction channels and their importance in pathogenesis /$ftopic editors: Aida Salameh, Katja Blanke and Stefan Dhein 210 $cFrontiers Media SA$d2014 210 31$aFrance :$cFrontiers Media SA,$d2014 215 $a1 online resource (252 pages) $cillustrations; digital, PDF file(s) 225 0 $aFrontiers Research Topics 300 $aBibliographic Level Mode of Issuance: Monograph 311 $a2-88919-238-5 330 $a?Cells live together, but die singly?, this sentence wrote the German physiologist Theodor Engelmann in 1875 and although he had no particular knowledge of gap junction channels (their structure was discovered around 100 years later) he described their functions very well: gap junction channels are essential for intercellular communication and crucial for the development of tissue and organs. But besides providing an opportunity for cells to communicate gap junction channels might also prevent intercellular communication by channel closure thereby preserving the surrounding healthy tissue in case of cellular necrosis. According to today?s understanding gap junction channels play an important role during embryonic development, during growth, wound healing and cell differentiation and are also involved in the process of learning. In the past decades most intensive research was done not only to unravel the physiological role of gap junction channels but also to extend our knowledge of the contribution of these channels in pathogenesis. A new frontier emerges in the field ?pharmacology of gap junctions? with the aim to control growth, differentiation, or electrical coupling via targeting gap junction channels pharmacologically.As we know today disturbances in gap junction synthesis, assembly and cellular distribution may account for various organic disorders from most different medical fields, such as the Charcot-Marie-Tooth neuropathy, epilepsy, Chagas-disease, Naxos-syndrome, congenital cardiac malformations, arrhythmias, cancer and as a very common disease in industrial countries atherosclerosis. Point mutations in gap junction channels have been found to cause hereditary diseases like the congenital deafness or the Charcot-Marie-Tooth neuropathy but the exact molecular mechanisms of gap junction malfunction from most of the mentioned illnesses are not fully understood. Moreover, in the last few years research has expanded on the role and function of connexin hemichannels and on a relatively new field the pannexins. The purpose of this volume is to give a comprehensive overview of the involvement of gap junction channels, hemichannels and pannexins on pathogenesis of inborn and acquired diseases and on emerging pharmacological strategies to target these channels.We welcome our colleagues to contribute their findings on the influence of gap junctions on pathogenesis and to unravel the secrets of intercellular communication. Take the lid off! 606 $aCytology$2HILCC 606 $aBiology$2HILCC 606 $aHealth & Biological Sciences$2HILCC 610 $adevelopment 610 $adifferentiation 610 $aGrowth 610 $apannexins 610 $aintercellular communication 610 $ahemichannels 610 $aConnexins 610 $agap junction 610 $aPharmacology 610 $ahuman diseases 615 7$aCytology 615 7$aBiology 615 7$aHealth & Biological Sciences 700 $aStefan Dhein$4auth$01366877 702 $aSalameh$b Aida 702 $aDhein$b S 702 $aBlanke$b Katja 801 0$bPQKB 801 2$bUkMaJRU 912 $a9910131532103321 996 $aMind the gap$93389396 997 $aUNINA LEADER 01002nam0 22002891i 450 001 UON00266035 005 20231205103734.517 010 $a86-305-0227-4 100 $a20050721d1994 |0itac50 ba 101 $ahbs 102 $aYU 105 $a|||| ||||| 200 1 $aBolnica$fPetar Cetkovic$gpriredio Radivoje Mikic 210 $aCetinje$cObod$d1994 215 $aXXI, 119 p.$d20 cm. 410 1$1001UON00266195$12001 $aRoman u Crnoj Gori$v17 620 $dCetinje$3UONL003857 676 $a891.82$cLetteratura serbo-croata$v21 700 1$aCETKOVIC$bPetar$3UONV154817$0690305 702 1$aMIKIC$bRadivoje$3UONV138017 712 $aObod$3UONV270362$4650 801 $aIT$bSOL$c20250620$gRICA 899 $aSIBA - SISTEMA BIBLIOTECARIO DI ATENEO$2UONSI 912 $aUON00266035 950 $aSIBA - SISTEMA BIBLIOTECARIO DI ATENEO$dSI CROATO A 1329 $eSI EO 37292 5 1329 996 $aBolnica$91241287 997 $aUNIOR