LEADER 01190nam0 22002891i 450 001 UON00261732 005 20231205103715.355 010 $a02-532-1613-3 100 $a20050228d2003 |0itac50 ba 101 $aeng 102 $aUS 105 $a|||| ||||| 200 1 $aApartheid's festival$econtesting South Africa's national pasts$fLeslie Witz 210 $aBloomington$cIndiana University Press$dc2003 215 $axii, 324 p.$cill.$d24 cm 410 1$1001UON00065561$12001 $aAfrican systems of thought$fGeneral Editors Charles S. Bird, Ivan Carp 606 $aSUDAFRICA $xPolitica$3UONC018558$2FI 620 $aUS$dBloomington (IN)$3UONL000188 676 $a320.968$cPOLITICA E GOVERNO DEL SUDAFRICA$v21 700 1$aWITZ$bLeslie$3UONV044063$0662374 712 $aIndiana University Press$3UONV246015$4650 801 $aIT$bSOL$c20240220$gRICA 899 $aSIBA - SISTEMA BIBLIOTECARIO DI ATENEO$2UONSI 912 $aUON00261732 950 $aSIBA - SISTEMA BIBLIOTECARIO DI ATENEO$dSI AA ST 419 $eSI AA 27237 5 419 996 $aApartheid's festival$91237474 997 $aUNIOR LEADER 04560nam 22008295 450 001 9910437894503321 005 20251113211248.0 010 $a1-283-91007-1 010 $a3-642-34094-6 024 7 $a10.1007/978-3-642-34094-9 035 $a(CKB)2670000000279790 035 $a(EBL)1082770 035 $a(OCoLC)821265731 035 $a(SSID)ssj0000799152 035 $a(PQKBManifestationID)11438348 035 $a(PQKBTitleCode)TC0000799152 035 $a(PQKBWorkID)10763945 035 $a(PQKB)11454828 035 $a(DE-He213)978-3-642-34094-9 035 $a(MiAaPQ)EBC1082770 035 $a(PPN)168326124 035 $a(EXLCZ)992670000000279790 100 $a20121116d2013 u| 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aSialo-Xenoantigenic Glycobiology $eMolecular Glycobiology of Sialylglycan-Xenoantigenic Determinants in Pig to Human Xenotransplantation /$fby Kwon-Ho Song, Cheorl-Ho Kim 205 $a1st ed. 2013. 210 1$aBerlin, Heidelberg :$cSpringer Berlin Heidelberg :$cImprint: Springer,$d2013. 215 $a1 online resource (75 p.) 225 1 $aSungkyunkwan University Outstanding Research,$x2195-3554 ;$v1 300 $aDescription based upon print version of record. 311 08$a3-642-43443-6 311 08$a3-642-34093-8 320 $aIncludes bibliographical references. 327 $aScreening of pig glycosyltransferase genes related to xenoantigens and their masking -- Cloning and tissue specific expression of pcmah and its alternative transcripts -- Functional characterization of pCMAH in the synthesis of N-glycolylneuraminic acid as the xenoantigenic determinant in pig-to-human xenotransplantation -- Identification of two alternative promoters of the pig CMP-N-acetylneuraminic acid hydroxylase gene -- Screening for xenoantigenic determinants formed by sialyltransferases. 330 $aCarbohydrate antigens on glycoconjugates of mammalian cells play crucial roles in various biological processes and are epitopes recognized by the immune system, as glycobiology has hugely been progressed during the past two decades. The book focuses on sialic acid?based xenoantigenes. In pig to human xenotransplantation, exposure of pig organs to human blood results in hyper acute rejection (HAR), caused by differences in carbohydrate epitopes between human and pig vascular endothelia. Although Gal-antigen as major antigen was eliminated, the remaining non-Gal antigens are considered to be xenoantigens. Sialosyl-Tn or Hanganutziu-Deicher (HD), are non-Gal antigens specific to natural antibodies in human. To overcome rejection responses such as HAR, studies of genes involved in carbohydrate antigens, causing xenoantigenicity, are necessary. Knowledge of pig glycosyltransferases are also useful to apply to xenoantigen masking or identification of the xenoantigenic sialylglycan(s). In the first chapter the screening for pig glycosyltransferase genes for xenoantigens is presented. In the chapter II to IV the cloning, characterization, and investigation of the regulatory mechanism of the pig CMAH gene in NeuGc biosynthesis is shown. Lastly, the effects of an alteration of pig glycosylation patterns on human serum-mediated cytotoxicity, caused by human sialyltransferases including hST6GalNAc IV is presented.  . 410 0$aSungkyunkwan University Outstanding Research,$x2195-3554 ;$v1 606 $aBiomedical engineering 606 $aMedicine$xResearch 606 $aBiology$xResearch 606 $aMedical genetics 606 $aClinical biochemistry 606 $aBiochemistry 606 $aBiomedical Engineering and Bioengineering 606 $aBiomedical Research 606 $aMedical Genetics 606 $aMedical Biochemistry 606 $aBiochemistry 615 0$aBiomedical engineering. 615 0$aMedicine$xResearch. 615 0$aBiology$xResearch. 615 0$aMedical genetics. 615 0$aClinical biochemistry. 615 0$aBiochemistry. 615 14$aBiomedical Engineering and Bioengineering. 615 24$aBiomedical Research. 615 24$aMedical Genetics. 615 24$aMedical Biochemistry. 615 24$aBiochemistry. 676 $a572.567 701 $aSong$b Kwon-ho$01059100 701 $aKim$b Cheorl-ho$01062709 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910437894503321 996 $aSialo-xenoantigenic glycobiology$94188344 997 $aUNINA