LEADER 01266nam0 22003011i 450 001 UON00260748 005 20231205103710.985 010 $a84-7658-713-9 100 $a20050125d2004 |0itac50 ba 101 $aspa 102 $aES 105 $a|||| ||||| 200 1 $aAlejo Carpentier$eAmerica, la imagen de una conjuncion$f[Angel Nogueira Dobarro... et al.] 210 $aRubi(Barcelona)$cAnthropos Editorial$d2004 215 $a159 p.$d18 cm 410 1$1001UON00265514$12001 $aHuellas$ememoria y texto de creacion. Serie Palabra e imagen de Iberoamérica. Barcelona$eAnthropos$v5 423 1$1001UON00374607$12001 $aAmerica, la imagen de una conjuncion 606 $aCARPENTIER ALEJO$3UONC044645$2FI 620 $dRubi (Barcelona)$3UONL003934 676 $aCu863$cLetteratura cubana. 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Accesso al full-text attraverso riconoscimento IP di Ateneo, proxy e/o Shibboleth 899 $aBIBLIOTECA DEL DIPARTIMENTO DI MATEMATICA E FISICA$1IT-CE0120$2VAN08 912 $fN 912 $aVAN00296560 950 $aBIBLIOTECA DEL DIPARTIMENTO DI MATEMATICA E FISICA$d08DLOAD e-Book 12179 $e08eMF12179 20250924 996 $aCombinatorial convexity and algebraic geometry$979419 997 $aUNICAMPANIA LEADER 03500nam 2200721 a 450 001 9910968093403321 005 20250709215331.0 010 $a9781299276826 010 $a1299276822 010 $a9782842542375 010 $a2842542371 024 7 $a10.1051/978-2-84254-237-5 035 $a(CKB)2560000000099461 035 $a(EBL)3155343 035 $a(SSID)ssj0000906519 035 $a(PQKBManifestationID)11536131 035 $a(PQKBTitleCode)TC0000906519 035 $a(PQKBWorkID)10843950 035 $a(PQKB)10824750 035 $a(Au-PeEL)EBL3155343 035 $a(CaPaEBR)ebr10667713 035 $a(CaONFJC)MIL458932 035 $a(OCoLC)922991221 035 $a(DE-B1597)634993 035 $a(DE-B1597)9782842542375 035 $a(Au-PeEL)EBL7156049 035 $a(OCoLC)1355220062 035 $a(OCoLC)834607434 035 $a(PPN)176628622 035 $a(FRCYB88811388)88811388 035 $a(FR-PaCSA)88811388 035 $a(MiAaPQ)EBC3155343 035 $a(Perlego)3799206 035 $a(MiAaPQ)EBC7156049 035 $a(EXLCZ)992560000000099461 100 $a20241012d2012 u| | 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 14$aThe clinibook $eclinical gene transfer : state of the art /$fedited by Odile Cohen-Haguenauer 205 $a1st ed. 210 $aParis $cEDP Sciences$d2012 215 $a1 online resource (589 p.) 300 $aDescription based upon print version of record. 311 08$a9782842541712 311 08$a2842541715 320 $aIncludes bibliographical references and index. 327 $apt. 1. Technologies and pre-clinical studies -- pt. 2. Clinical trials and regulatory issues. 330 $aThis book provides a 2012 reference for state-of-the-art gene transfer technology and the different aspects of its clinical translation with a focus on European-based initiatives. As examples of successful outcomes, recent clinical trials are presented together with Ethical, Safety and Regulatory issues, which are discussed. The broad range of various technologies is covered whether addressing direct in vivo gene transfer like with AAV, Adeno or non-viral vectors or ex-vivo genetically engineered cells including induced pluripotent stem cells (iPS) with integrating vectors such as retrovirus, lentivirus or transposon-derived systems. The critical path to clinical implementation is covered in the second part describing currently available tools - such as molecular imaging, ex-vivo organ cultures and high-throughput technologies used for evaluation of criteria towards a go-or-no go decision to move to the clinic; in addition, utmost salient biosafety and immunotoxicology aspects are discussed. This book is ideal for postgraduates, undergraduates, scientists, clinicians, regulators and patients' advocacy groups looking for states-of-the-art information as well as emerging prospects - including gene targeting and homologous recombination - in gene transfer intended for clinical translation. 606 $aGenetic transformation 615 0$aGenetic transformation. 676 $a571.96 700 $aCohen-Haguenauer$b Odile, $4aut$4http://id.loc.gov/vocabulary/relators/aut$01087562 701 $aCohen-Haguenauer$b Odile$01087562 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910968093403321 996 $aThe clinibook$94355944 997 $aUNINA