LEADER 01135nam0 22002771i 450 001 UON00225179 005 20231205103433.651 010 $a01-411-8168-0 100 $a20030730d2000 |0itac50 ba 101 $aeng 102 $aGB 105 $a|||| ||||| 200 1 $aTwo serious ladies$fJane Bowles$gwith an introduction by Lorna Sage 210 $aLondon$cPenguin Books ; in association with Peter Owen$d2000. xiii$d181 p. ; 20 cm. 410 1$1001UON00051586$12001 $aPenguin Classics$1210 $aLondon$aParis ; New York$cPenguin Books 620 $aGB$dLondon$3UONL003044 676 $a813.5$cNarrativa americana in inglese. 1900-1999$v21 700 1$aBOWLES$bPaul$3UONV089100$0146879 702 1$aSAGE$bLorna$3UONV119112 712 $aPenguin Books$3UONV246450$4650 801 $aIT$bSOL$c20240220$gRICA 899 $aSIBA - SISTEMA BIBLIOTECARIO DI ATENEO$2UONSI 912 $aUON00225179 950 $aSIBA - SISTEMA BIBLIOTECARIO DI ATENEO$dSI NordA V A 0059 $eSI LO 66946 7 0059 996 $aTwo serious ladies$91269841 997 $aUNIOR LEADER 04011nam 22005775 450 001 9910918693903321 005 20241221115234.0 010 $a9783031711800$b(electronic bk.) 010 $z9783031711794 024 7 $a10.1007/978-3-031-71180-0 035 $a(MiAaPQ)EBC31855495 035 $a(Au-PeEL)EBL31855495 035 $a(CKB)37065128600041 035 $a(DE-He213)978-3-031-71180-0 035 $a(EXLCZ)9937065128600041 100 $a20241221d2024 u| 0 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aAcute Lymphoblastic Leukemia in Children and Adolescents /$fedited by Gabriele Escherich, Valentino Conter 205 $a1st ed. 2024. 210 1$aCham :$cSpringer Nature Switzerland :$cImprint: Springer,$d2024. 215 $a1 online resource (387 pages) 225 1 $aPediatric Oncology,$x2191-0812 311 08$aPrint version: Escherich, Gabriele Acute Lymphoblastic Leukemia in Children and Adolescents Cham : Springer,c2025 9783031711794 327 $aPart I: Epidemiology and Predisposition of ALL. Genetic predisposition for leukemia -- Association of leukemia with genetic diseases. Part II: Biology and Diagnostics of ALL. Genetic aberrations and profiles in Bcp ALL -- Genetic aberrations and profiles in T ALL -- Features of ALL in children, adolescents, and young adults -- Immunological Diagnosis -- MRD response: FCM, Ig/Tcr PCR, NGS. Part III: Stratification and treatment considerations in ALL. Stratification and treatment of Bcp ALL and T-ALL -- Stratification and treatment of Adolescents/AYA -- CNS therapy -- Stratification and treatment of Down Syndrome -- Stratification and treatment of Infants -- Stratification and treatment of BCR/ABL and ABL class fusion. Part IV: Immunotherapy in ALL. Immunotherapy with monoclonal antibodies -- Immunotherapy with CAR-T. Part V: Strategies for patients with Lymphoblastic Lymphoma/mature B-ALL. Stratification and treatment of lymphoblastic lymphomas -- Stratification and treatment of mature B ALLs. Part VI: Strategies for patients with refractory or relapsed ALL. Relapses: classification and treatment -- HSCT in 1rst CR and after subsequent CRs: indications, conditioning regimens. Part VII: Toxicity and Late effects following ALL treatment. Genetic disposition for toxicity Late toxicity including SMN -- late effects after HSCT. Part VIII: Perspectives and Future directions -- Global disparities in ALL treatment and outcome -- New agents. 330 $aThis book is a comprehensive and up-to-date compendium on diagnosis, treatment and late effects of Acute Lymphoblastic Leukemia in children, adolescents and young adults. After introductory chapters on the epidemiology and biology of ALL, treatment considerations are extensively reviewed, also with emphasis on special patient groups, such as Infants, Adolescents and patients with Down Syndrome. Immunotherapy in Acute Lymphoblastic Leukemia is reviewed as well as strategies for patients with Lymphoblastic Lymphoma and for patients with refractory or relapsed ALL. The authors are internationally recognized experts and offer up-to-date insights on etiology, biology, and treatment. This book will prove indispensable for those treating or researching into this disease. 410 0$aPediatric Oncology,$x2191-0812 606 $aHematology 606 $aPediatrics 606 $aOncology 606 $aHematology 606 $aPediatrics 606 $aOncology 615 0$aHematology. 615 0$aPediatrics. 615 0$aOncology. 615 14$aHematology. 615 24$aPediatrics. 615 24$aOncology. 676 $a616.15 700 $aEscherich$b Gabriele$01781157 701 $aConter$b Valentino$01781158 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 912 $a9910918693903321 996 $aAcute Lymphoblastic Leukemia in Children and Adolescents$94305930 997 $aUNINA