LEADER 03702nam 22004815 450 001 9910154671503321 005 20200705203729.0 024 7 $a10.1007/978-1-4939-6460-4 035 $a(CKB)3710000000964604 035 $a(DE-He213)978-1-4939-6460-4 035 $a(MiAaPQ)EBC4747261 035 $a(PPN)19713467X 035 $a(EXLCZ)993710000000964604 100 $a20161123d2016 u| 0 101 0 $aeng 135 $aurnn#008mamaa 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aFrontiers in Cancer Research $eEvolutionary Foundations, Revolutionary Directions /$fedited by Carlo C. Maley, Mel Greaves 205 $a1st ed. 2016. 210 1$aNew York, NY :$cSpringer New York :$cImprint: Springer,$d2016. 215 $a1 online resource (XIV, 258 p. 28 illus., 17 illus. in color.) 311 $a1-4939-6458-5 311 $a1-4939-6460-7 320 $aIncludes bibliographical references at the end of each chapters and index. 327 $a1. The Evolutionary Foundations of Cancer Research -- 2. The Role of Theory in Cancer Research -- 3. Population Genetics of Neoplasms -- 4. Diversity in Neoplasms -- 5. How do Mutant Clones Expand in Normal Tissue? -- 6. Cancer Stem Cells in Tumor Evolution -- 7. Measuring Rather than Imagining Somatic Cell Selection and Clonal Evolution -- 8. The Darwinian Dynamics of Motility and Metastasis -- 9. Applying Evolutionary Principles to Cancer Therapy -- 10. Mismatches with Our Ancestral Environments and Cancer Risk -- 11. The Evolution of Cancer Suppression Mechanisms -- 12. Epilogue: How can we Thwart the Evolutionary Resilience of Cancer?. 330 $aThis is the ideal book for anyone contemplating starting a career in, or shifting their career to, studying the dynamics that drive cancer progression and its response to therapy. Topics include the theory and population genetics of cancers, genetic diversity within tumors (intra-tumor heterogeneity), understanding how mutant clones expand in tissues, the role of cancer stem cells in the dynamics of tumors, the evolution of metastasis, and how to improve cancer therapy by addressing the evolution of cancers in response to our interventions. There are also chapters on the patterns of cancer susceptibility in humans due to a mismatch between our modern environment and the environment in which our ancestors evolved, as well as a chapter on the evolution of cancer suppression mechanisms that have evolved in different species, particularly the large long-lived animals like elephants and whales that are better at suppressing cancers than humans. This book serves as a primer on the evolutionary and ecological theory of cancer- the framework upon which all the details of cancer may be hung. It is ideal for oncologists and cancer researchers interested in evolutionary theory, and evolutionary biologists and ecologists interested in gaining insights into cancer development and prevention. . 606 $aCancer research 606 $aPharmacology 606 $aCancer Research$3https://scigraph.springernature.com/ontologies/product-market-codes/B11001 606 $aPharmacology/Toxicology$3https://scigraph.springernature.com/ontologies/product-market-codes/B21007 615 0$aCancer research. 615 0$aPharmacology. 615 14$aCancer Research. 615 24$aPharmacology/Toxicology. 676 $a614.5999 702 $aMaley$b Carlo C$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aGreaves$b Mel$4edt$4http://id.loc.gov/vocabulary/relators/edt 906 $aBOOK 912 $a9910154671503321 996 $aFrontiers in Cancer Research$92524212 997 $aUNINA LEADER 01315nam0 22003251i 450 001 UON00223382 005 20231205103425.165 010 $a06-7444-611-9 100 $a20030730d1998 |0itac50 ba 101 $aeng 102 $aGB 105 $a|||| ||||| 200 1 $aIn search of Africa$fManthia Diawara 210 $aCambridge$aLondon$cHarward University Press$d1998 215 $aIX, 288 p.$cill.$d24 cm. 606 $aAFRICANI$xStati Uniti d'America$xIdentità etnica$3UONC047632$2FI 606 $aAFRO-AMERICANI$xRelazioni con africani$3UONC047633$2FI 606 $aArte Afro-americana$3UONC040005$2FI 606 $aPANAFRICANISMO$3UONC023829$2FI 620 $dCambridge$3UONL000022 620 $aGB$dLondon$3UONL003044 676 $a973.0496$cStati Uniti. 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