LEADER 01087nam0 22002651i 450 001 UON00093318 005 20231205102520.912 100 $a20020107d1995 |0itac50 ba 101 $aita 102 $aIT 105 $a|||| ||||| 200 1 $aPropedeutica al latino universitario$fA. Traina$gG. Bernardi Perini 210 $aBologna$cPātron$d1996 525 p. ; 22 cm 410 1$1001UON00087215$12001 $aTesti e manuali per l'insegnamento universitario del latino$fcollana diretta da Alfonso Traina$v9 620 $aIT$dBologna$3UONL000085 686 $aQ2$cLATINO$2A 700 1$aTRAINA$bAlfonso$3UONV055921$0161858 701 1$aBERNARDI PERINI$bGiorgio$3UONV057129$069401 712 $aPātron$3UONV265630$4650 801 $aIT$bSOL$c20240220$gRICA 899 $aSIBA - SISTEMA BIBLIOTECARIO DI ATENEO$2UONSI 912 $aUON00093318 950 $aSIBA - SISTEMA BIBLIOTECARIO DI ATENEO$dSI Q 2 130 $eSI MC 20241 7 996 $aPropedeutica al latino universitario$9972151 997 $aUNIOR LEADER 03525nam 2200457z- 450 001 9910220036903321 005 20210212 035 $a(CKB)3800000000216408 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/61392 035 $a(oapen)doab61392 035 $a(EXLCZ)993800000000216408 100 $a20202102d2017 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aTumor Hypoxia: Impact in Tumorigenesis, Diagnosis, Prognosis and Therapeutics 210 $cFrontiers Media SA$d2017 215 $a1 online resource (113 p.) 225 1 $aFrontiers Research Topics 311 08$a2-88945-064-3 330 $aHypoxic regions have been identified within tumors and its presence has been linked to malignant progression, metastasis, resistance to therapy, and poor clinical outcomes following treatment. Acute and chronic hypoxia are integral components of tumor microenvironment and conduce to metabolic adaptations of tumor cells leading to genetic instability, intratumor heterogeneity and malignant progression. On the success of our fight against cancer, the continued adaptability of tumors to their microenvironmental stresses, such as hypoxia, must be considered. Tumor cells are endowed with a very high plasticity and capacity to adapt. It is our challenge to find populations and conditions of the tumor microenvironment germane for target success. Interdisciplinary work will be the key for achievement of these goals. This e-book is a compendium of original reports and review articles contributed by world-class experts in the field of tumor hypoxia. This material will be useful to foster discussion and increase understanding of the involvement of hypoxia in tumorigenesis, biomarker development, and therapeutics.Hypoxic regions have been identified within tumors and its presence has been linked to malignant progression, metastasis, resistance to therapy, and poor clinical outcomes following treatment. Acute and chronic hypoxia are integral components of tumor microenvironment and conduce to metabolic adaptations of tumor cells leading to genetic instability, intratumor heterogeneity and malignant progression. On the success of our fight against cancer, the continued adaptability of tumors to their microenvironmental stresses, such as hypoxia, must be considered. Tumor cells are endowed with a very high plasticity and capacity to adapt. It is our challenge to find populations and conditions of the tumor microenvironment germane for target success. Interdisciplinary work will be the key for achievement of these goals. This e-book is a compendium of original reports and review articles contributed by world-class experts in the field of tumor hypoxia. This material will be useful to foster discussion and increase understanding of the involvement of hypoxia in tumorigenesis, biomarker development, and therapeutics. 517 $aTumor Hypoxia 606 $aMedicine$2bicssc 610 $abiomarkers 610 $aHIF 610 $ahypoxia 610 $aLeukemia 610 $amicroenvironment 610 $apH 610 $aStem Cells 610 $astress 610 $atherapy 610 $atumor 615 7$aMedicine 700 $aChristian R. Gomez$4auth$01296299 906 $aBOOK 912 $a9910220036903321 996 $aTumor Hypoxia: Impact in Tumorigenesis, Diagnosis, Prognosis and Therapeutics$93023973 997 $aUNINA