LEADER 01148nam0 22003011i 450 001 UON00079319 005 20231205102423.179 010 $a04-15-02243-6 100 $a20020107d1997 |0itac50 ba 101 $aeng 102 $aGB 105 $a|||| ||||| 200 1 $aMaltese$fAlbert Borg, Marie Azzopardi-Alexander 210 $aLondon$cRoutledge$d1997 215 $axvii, 395 p.$d24 cm 410 1$1001UON00067325$12001 $aDescriptive grammars$fSeries editor: Bernard Comrie 606 $aLINGUA MALTESE$xGrammatica$3UONC021842$2FI 620 $aGB$dLondon$3UONL003044 676 $a492.77$cLingua araba. Varianti storiche e geografiche$v21 700 1$aBORG$bAlbert$3UONV052090$0661093 701 1$aAZZOPARDI-ALEXANDER$bMarie$3UONV052091$0661094 712 $aRoutledge$3UONV248939$4650 801 $aIT$bSOL$c20240220$gRICA 899 $aSIBA - SISTEMA BIBLIOTECARIO DI ATENEO$2UONSI 912 $aUON00079319 950 $aSIBA - SISTEMA BIBLIOTECARIO DI ATENEO$dSI ET II B i 001 $eSI AA 19563 7 001 996 $aMaltese$91299005 997 $aUNIOR LEADER 03985nam 22007575 450 001 9910506382103321 005 20260213093407.0 010 $a3-030-85281-4 024 7 $a10.1007/978-3-030-85281-8 035 $a(CKB)4950000000281514 035 $a(MiAaPQ)EBC6785157 035 $a(Au-PeEL)EBL6785157 035 $a(OCoLC)1280048465 035 $a(PPN)258297212 035 $a(BIP)81923404 035 $a(BIP)80998185 035 $a(DE-He213)978-3-030-85281-8 035 $a(EXLCZ)994950000000281514 100 $a20211018d2021 u| 0 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aBiophysical and Computational Tools in Drug Discovery /$fedited by Anil Kumar Saxena 205 $a1st ed. 2021. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2021. 215 $a1 online resource (405 pages) 225 1 $aTopics in Medicinal Chemistry,$x1862-247X ;$v37 311 08$a3-030-85280-6 327 $aKinetic profiling of fragments by TR-FRET -- Role of Structural biology in drug discovery with emphasis on X-ray crystallography -- A computational search for peptide vaccines using novel mathematical descriptors of sequences of emerging pathogens -- Solution NMR methods in Drug Discovery for the series -- Applications of Mass Spectrometry in Herbal Drug Research -- Generative machine learning for drug discovery -- Structure and ligand based virtual screening in drug discovery -- Quantum Chemical and Quantum Dynamics Techniques for Drug Discovery Including Bioinorganic Compounds. 330 $aThis book reviews recent physicochemical and biophysical techniques applied in drug discovery research, and it outlines the latest advances in computational drug design. Divided into 10 chapters, the book discusses about the role of structural biology in drug discovery, and offers useful application cases of several biophysical and computational methods, including time-resolved fluorometry (TRF) with Förster resonance energy transfer (FRET), X-Ray crystallography, nuclear magnetic resonance spectroscopy, mass spectroscopy, generative machine learning for inverse molecular design, quantum mechanics/molecular mechanics (QM/MM,ONIOM) and quantum molecular dynamics (QMT) methods. Particular attention is given to computational search techniques applied to peptide vaccines using novel mathematical descriptors and structure and ligand-based virtual screening techniques in drug discovery research. Given its scope, the book is a valuable resource for students, researchers and professionals frompharmaceutical industry interested in drug design and discovery. 410 0$aTopics in Medicinal Chemistry,$x1862-247X ;$v37 606 $aPharmaceutical chemistry 606 $aPhysical biochemistry 606 $aBiology$xTechnique 606 $aChemistry$xData processing 606 $aChemistry, Physical and theoretical 606 $aBiophysics 606 $aMedicinal Chemistry 606 $aBiophysical Chemistry 606 $aBiological Techniques 606 $aComputational Chemistry 606 $aPhysical Chemistry 606 $aBiophysical Methods 615 0$aPharmaceutical chemistry. 615 0$aPhysical biochemistry. 615 0$aBiology$xTechnique. 615 0$aChemistry$xData processing. 615 0$aChemistry, Physical and theoretical. 615 0$aBiophysics. 615 14$aMedicinal Chemistry. 615 24$aBiophysical Chemistry. 615 24$aBiological Techniques. 615 24$aComputational Chemistry. 615 24$aPhysical Chemistry. 615 24$aBiophysical Methods. 676 $a615.1 702 $aSaxena$b Anil Kumar 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910506382103321 996 $aBiophysical and Computational Tools in Drug Discovery$92025207 997 $aUNINA