LEADER 05148nam 22006135 450 001 9910300333603321 005 20200701173037.0 010 $a3-7091-1535-3 024 7 $a10.1007/978-3-7091-1535-0 035 $a(CKB)2670000000423546 035 $a(EBL)1474367 035 $a(SSID)ssj0001010552 035 $a(PQKBManifestationID)11584842 035 $a(PQKBTitleCode)TC0001010552 035 $a(PQKBWorkID)11003476 035 $a(PQKB)10082251 035 $a(MiAaPQ)EBC1474367 035 $a(DE-He213)978-3-7091-1535-0 035 $a(PPN)172431816 035 $a(EXLCZ)992670000000423546 100 $a20130902d2014 u| 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 14$aThe Intervertebral Disc $eMolecular and Structural Studies of the Disc in Health and Disease /$fedited by Irving M. Shapiro, Makarand V. Risbud 205 $a1st ed. 2014. 210 1$aVienna :$cSpringer Vienna :$cImprint: Springer,$d2014. 215 $a1 online resource (440 p.) 300 $aDescription based upon print version of record. 311 $a3-7091-1534-5 320 $aIncludes bibliographical references and index. 327 $aBiomechanical and Molecular Studies of the Intervertebral Disc: Introduction to the Structure, Function and Comparative Anatomy of the Vertebrae and the Intervertebral Disc -- The Intervertebral Disc: Overview of Disc Mechanics -- Development of the Intervertebral Disc -- Proteoglycans of the Intervertebral Disc -- Collagen and Other Proteins of the Nucleus Pulposus, Annulus Fibrosus and Cartilage Endplates -- Microenvironmental Regulation of Cell Function and Extracellular Matrix Synthesis by Disc Cells -- The Effects of Mechanical Forces on Nucleus and Annulus Cells -- The Role of the ADAMTS Proteins in the Intervertebral Disc -- Intervertebral Disc Disease: Pathogenesis and Current Treatment Modalities: Epidemiology of Lumbar Disc Degeneration -- Genetic Basis of Intervertebral Disc Degeneration -- Pathogenesis of Intervertebral Disc Degeneration -- Imaging Modalities for Studying Disc Pathology -- Surgical Indications for Lumbar Degenerative Disease -- Spinal Motion Restoration Devices for the Degenerate Disc -- The Non-Surgical Treatment of Back Pain -- Back Pain and Disc Degeneration: Are They Linked?- Clinical Features and Pathobiology of Chordoma -- Models of Disc Disease and Biological Regeneration: Large Animal Models of Disc Degeneration -- Intervertebral Disc Herniation -- The Sand Rat (Psammomys obesus obesus) Model of Spontaneous, Age-Related Intervertebral Disc Generation -- Use of Knockout and Transgenic Mouse Models in Disc Research -- Intervertebral Disc Culture Models and Their Applications to Study Pathogenesis and Repair -- Use of Stem Cells to Regenerate the Disc -- Gene Therapy Approaches for Disc Regeneration -- Enhancing Disc Repair by Growth Factors and Other Modalities -- Tissue Engineering of the Disc. 330 $aThe intervertebral disc is composed of a complex tissue that separates neighboring vertebrae, permits a wide range of motion, and cushions the high biomechanical forces on the spine. Disc degeneration leads to a loss of function and is often associated with excruciating pain. Written by leading scientists and clinicians, this is the only book in the past fifty years devoted entirely to the study of the intervertebral disc. The first part of the book provides a review of the basic biology of the disc in health and disease. The second part considers strategies for mitigating the effects of disc degeneration and discusses the possibility of engineering replacement tissues. The final section is dedicated to approaches that model normal development, and the elucidation of the pathogenesis of degenerative disc disease using animal, organ and cell culture techniques.  This unique and authoritative book bridges the gap between the basic and clinical sciences; its target audience includes basic scientists, orthopedists, neurologists, rehabilitation and physical therapists, primary care physicians and chiropractors, while it also addresses the needs of graduate students, medical students, interns, fellows, and patients who suffer from disc-related pathologies. 606 $aOrthopedics 606 $aNeurosurgery 606 $aSurgical Orthopedics$3https://scigraph.springernature.com/ontologies/product-market-codes/H45027 606 $aNeurosurgery$3https://scigraph.springernature.com/ontologies/product-market-codes/H39000 606 $aOrthopedics$3https://scigraph.springernature.com/ontologies/product-market-codes/H45000 615 0$aOrthopedics. 615 0$aNeurosurgery. 615 14$aSurgical Orthopedics. 615 24$aNeurosurgery. 615 24$aOrthopedics. 676 $a617.5 676 $a617.5/6 676 $a617.56 702 $aShapiro$b Irving M$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aRisbud$b Makarand V$4edt$4http://id.loc.gov/vocabulary/relators/edt 906 $aBOOK 912 $a9910300333603321 996 $aThe Intervertebral Disc$92505590 997 $aUNINA LEADER 01021nam0 22002651i 450 001 UON00072237 005 20231205102355.400 100 $a20020107d1983 |0itac50 ba 101 $afre 102 $aFR 105 $a|||| ||||| 200 1 $aVictoire assuree$e(Souvenirs: Algerie 1920-1954)$fMohammed Belhalfaoui 210 $a[Francia]$cSNED ; Paris$cPublisud$dc1983 215 $a149 p.$d22 cm 606 $aAlgeria$xDocumenti$3UONC021575$2FI 620 $aFR$dParis$3UONL002984 676 $a965.0099$cSTORIA DELL'ALGERIA - Biografie$v21 700 1$aBELHALFAOUI$bMohamed$3UONV042121$0657190 712 $aPublisud$3UONV248146$4650 801 $aIT$bSOL$c20260410$gRICA 899 $aSIBA - SISTEMA BIBLIOTECARIO DI ATENEO E ARCHIVIO STORICO$2UONSI 912 $aUON00072237 950 $aSIBA - SISTEMA BIBLIOTECARIO DI ATENEO E ARCHIVIO STORICO$dSI 3 0295 $eSI AA 15071 5 0295 996 $aVictoire assuree$91159343 997 $aUNIOR