LEADER 01200nam0 22002891i 450 001 UON00072126 005 20231205102355.13 100 $a20020107d1986 |0itac50 ba 101 $aara 102 $aTN 105 $a|||| ||||| 200 1 $aZad al-musafir wa qut al hadir$fIbn al-Gazzar$gtahqiq Muhammad Suissi, al-Radi al-Gazi 210 $aTunis$cal-Dar al- arabiyya li-'l-kitab$d[1986?] 215 $a292 p.$d24 cm 410 1$1001UON00066326$12001 $aIhya' 'l-turat al- ilmi$fal-Mu'assasa 'l-wataniyya li-'l-targama wa 'l-tahqiq wa 'l-dirasat$v2 606 $aMedicina araba$3UONC018211$2FI 620 $aTN$dTunis$3UONL000089 676 $a615$cFarmacologia e terapeutica$v21 700 0$aIBN AL-GAZZAR$3UONV047242$0658680 702 1$aSUISSI$bMuhammad$3UONV047243 712 $aal-Dar al- arabiyya li-'l-kitab$3UONV257544$4650 801 $aIT$bSOL$c20250307$gRICA 899 $aSIBA - SISTEMA BIBLIOTECARIO DI ATENEO$2UONSI 912 $aUON00072126 950 $aSIBA - SISTEMA BIBLIOTECARIO DI ATENEO$dSI XVIII A 004 $eSI AA 14844 5 004 996 $aZad al-musafir wa qut al hadir$91159472 997 $aUNIOR LEADER 05355nam 22007215 450 001 9910946349603321 005 20250111115244.0 010 $a9783031685057 010 $a3031685059 024 7 $a10.1007/978-3-031-68505-7 035 $a(MiAaPQ)EBC31876179 035 $a(Au-PeEL)EBL31876179 035 $a(CKB)37188986900041 035 $a(DE-He213)978-3-031-68505-7 035 $a(OCoLC)1493054985 035 $a(EXLCZ)9937188986900041 100 $a20250111d2024 u| 0 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aBiology of Bladder Cancer $eFrom Molecular Insights to Clinical Strategies /$fedited by Margaret A. Knowles, Lars Dyrskjøt 205 $a1st ed. 2024. 210 1$aCham :$cSpringer Nature Switzerland :$cImprint: Springer,$d2024. 215 $a1 online resource (946 pages) 311 08$a9783031685040 311 08$a3031685040 327 $aPart I. Fundamentals of Bladder Cancer -- Chapter 1. Epidemiology of Bladder Cancer -- Chapter 2. Genetic Predisposition to Bladder Cancer -- Chapter 3. Human Urothelium -- Chapter 4. Bladder Cancer Pathology -- Chapter 5. Overview of Standard Therapy of Non Muscle-Invasive Bladder Cancer -- Chapter 6. Overview of Standard Therapy of Muscle-Invasive Bladder Cancer -- Part II. Molecular Genetics and Oncogenesis in Bladder Cancer -- Chapter 7. From Normalcy to Neoplasia: Mutational Events during Bladder Tumor Evolution -- Chapter 8. Cell Cycle Regulators as Oncogenic Drivers in Bladder Cancer -- Chapter 9. DNA Repair Pathway Alterations in Bladder Cancer -- Chapter 10. DNA Methylation and Chromatin Regulators in Bladder Cancer -- Part III. Pathogenesis and Microenvironment Dynamics in Bladder Cancer -- Chapter 11. Molecular Pathogenesis: Field Cancerization and Clonal Evolution in Urothelial Cancer Initiation and Progression -- Chapter 12. The Bladder Tumor Microenvironment -- Part IV. Molecular and Histological Subtypes of Bladder Cancer -- Chapter 13. Molecular Subtypes of Non-Muscle-Invasive Bladder Cancer -- Chapter 14. Molecular Subtypes of Muscle-Invasive Bladder Cancer -- Chapter 15. Molecular Features of Divergent Differentiation and Histological Subtypes in Bladder Cancer -- Part V. Experimental Models of Bladder Cancer -- Chapter 16. The Emerging Landscape of Mouse Bladder Cancer Models -- Chapter 17. In Vitro Bladder Cancer Models -- Part VI. Biomarkers for Diagnosis and Treatment of Bladder Cancer -- Chapter 18. Urine Biomarkers for Bladder Cancer Diagnosis and Screening -- Chapter 19. Blood-Based Biomarkers for Bladder Cancer Diagnosis and Prognosis -- Chapter 20. Mechanisms and Biomarkers of Response to BCG and Chemotherapy in Bladder Cancer -- Part VII. Therapeutic Application based on Molecular Insights -- Chapter 21. New Treatment Approaches in Non-Muscle-Invasive Bladder Cancer -- Chapter 22. New Treatment Approaches in Muscle-Invasive Bladder Cancer -- Chapter 23. Targeting the Immune Checkpoint in Bladder Cancer -- Part VIII. Future Directions in Bladder Cancer Research -- Chapter 24. Future Directions in Bladder Cancer Research and Clinical Implications. 330 $aThis book provides an update on the current understanding of various aspects of bladder cancer biology and introduces clinical manifestations together with current and novel treatment aspects. Key concepts covered include epidemiology and genetic predisposition to bladder cancer, insights into the mutational events and molecular pathogenesis of bladder cancer, detailed analyses of tumor subtypes, and references to common experimental models used in the study of bladder cancer. The book addresses critical issues such as the molecular features that contribute to the development of bladder cancer, the impact of the tumor microenvironment on disease progression, and the potential of novel urine- and blood-based biomarkers for diagnosis and treatment. Innovative therapeutic applications are also explored, including targeting immune checkpoints and personalized medicine approaches. Aimed at early career and experienced researchers or clinicians alike, this volume provides an interdisciplinary understanding of bladder cancer. Delving into the biology, pathology, and clinical aspects of the disease, it serves as an indispensable resource for understanding bladder cancer's complexity. 606 $aCancer 606 $aOncology 606 $aOncogenes 606 $aTumor markers 606 $aCancer$xTreatment 606 $aCancer Biology 606 $aCancers 606 $aOncology 606 $aOncogenes 606 $aTumour Biomarkers 606 $aCancer Therapy 615 0$aCancer. 615 0$aOncology. 615 0$aOncogenes. 615 0$aTumor markers. 615 0$aCancer$xTreatment. 615 14$aCancer Biology. 615 24$aCancers. 615 24$aOncology. 615 24$aOncogenes. 615 24$aTumour Biomarkers. 615 24$aCancer Therapy. 676 $a571.978 676 $a616.994 700 $aKnowles$b Margaret A$01794878 701 $aDyrskjøt$b Lars$01794879 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910946349603321 996 $aBiology of Bladder Cancer$94335871 997 $aUNINA