LEADER 07017nam 22017895 450 001 9910154744803321 005 20190708092533.0 010 $a1-4008-8149-8 024 7 $a10.1515/9781400881499 035 $a(CKB)3710000000631343 035 $a(SSID)ssj0001651272 035 $a(PQKBManifestationID)16426197 035 $a(PQKBTitleCode)TC0001651272 035 $a(PQKBWorkID)13976268 035 $a(PQKB)10755492 035 $a(MiAaPQ)EBC4738514 035 $a(DE-B1597)467991 035 $a(OCoLC)979882335 035 $a(DE-B1597)9781400881499 035 $a(EXLCZ)993710000000631343 100 $a20190708d2016 fg 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt 182 $cc 183 $acr 200 10$aEtale Homotopy of Simplicial Schemes. (AM-104), Volume 104 /$fEric M. Friedlander 210 1$aPrinceton, NJ : $cPrinceton University Press, $d[2016] 210 4$d©1983 215 $a1 online resource (193 pages) 225 0 $aAnnals of Mathematics Studies ;$v231 300 $aBibliographic Level Mode of Issuance: Monograph 311 $a0-691-08317-7 311 $a0-691-08288-X 320 $aIncludes bibliographical references and index. 327 $tFrontmatter -- $tINTRODUCTION -- $t1. ETALE SITE OF A SIMPLICIAL SCHEME -- $t2. SHEAVES AND COHOMOLOGY -- $t3. COHOMOLOGY VIA HYPERCOVERINGS -- $t4. ETALE TOPOLOGICAL TYPE -- $t5. HOMOTOPY INVARIANTS -- $t6. WEAK EQUIVALENCES, COMPLETIONS, AND HOMOTOPY LIMITS -- $t7. FINITENESS AND HOMOLOGY -- $t8. COMPARISON OF HOMOTOPY TYPES -- $t9. APPLICATIONS TO TOPOLOGY -- $t10. COMPARISON OF GEOMETRIC AND HOMOTOPY THEORETIC FIBRES -- $t11. APPLICATIONS TO GEOMETRY -- $t12. APPLICATIONS TO FINITE CHE VALLEY GROUPS -- $t13. FUNCTION COMPLEXES -- $t14. RELATIVE COHOMOLOGY -- $t15. TUBULAR NEIGHBORHOODS -- $t16. GENERALIZED COHOMOLOGY -- $t17. POINCARÉ DUALITY AND LOCALLY COMPACT HOMOLOGY -- $tREFERENCES -- $tINDEX -- $tBackmatter 330 $aThis book presents a coherent account of the current status of etale homotopy theory, a topological theory introduced into abstract algebraic geometry by M. Artin and B. Mazur. Eric M. Friedlander presents many of his own applications of this theory to algebraic topology, finite Chevalley groups, and algebraic geometry. Of particular interest are the discussions concerning the Adams Conjecture, K-theories of finite fields, and Poincare duality. Because these applications have required repeated modifications of the original formulation of etale homotopy theory, the author provides a new treatment of the foundations which is more general and more precise than previous versions.One purpose of this book is to offer the basic techniques and results of etale homotopy theory to topologists and algebraic geometers who may then apply the theory in their own work. With a view to such future applications, the author has introduced a number of new constructions (function complexes, relative homology and cohomology, generalized cohomology) which have immediately proved applicable to algebraic K-theory. 410 0$aAnnals of mathematics studies ;$vNumber 104. 606 $aHomotopy theory 606 $aSchemes (Algebraic geometry) 606 $aHomology theory 610 $aAbelian group. 610 $aAdams operation. 610 $aAdjoint functors. 610 $aAlexander Grothendieck. 610 $aAlgebraic K-theory. 610 $aAlgebraic closure. 610 $aAlgebraic geometry. 610 $aAlgebraic group. 610 $aAlgebraic number theory. 610 $aAlgebraic structure. 610 $aAlgebraic topology (object). 610 $aAlgebraic topology. 610 $aAlgebraic variety. 610 $aAlgebraically closed field. 610 $aAutomorphism. 610 $aBase change. 610 $aCap product. 610 $aCartesian product. 610 $aClosed immersion. 610 $aCodimension. 610 $aCoefficient. 610 $aCohomology. 610 $aComparison theorem. 610 $aComplex number. 610 $aComplex vector bundle. 610 $aConnected component (graph theory). 610 $aConnected space. 610 $aCoprime integers. 610 $aCorollary. 610 $aCovering space. 610 $aDerived functor. 610 $aDimension (vector space). 610 $aDisjoint union. 610 $aEmbedding. 610 $aExistence theorem. 610 $aExt functor. 610 $aExterior algebra. 610 $aFiber bundle. 610 $aFibration. 610 $aFinite field. 610 $aFinite group. 610 $aFree group. 610 $aFunctor. 610 $aFundamental group. 610 $aGalois cohomology. 610 $aGalois extension. 610 $aGeometry. 610 $aGrothendieck topology. 610 $aHomogeneous space. 610 $aHomological algebra. 610 $aHomology (mathematics). 610 $aHomomorphism. 610 $aHomotopy category. 610 $aHomotopy group. 610 $aHomotopy. 610 $aIntegral domain. 610 $aIntersection (set theory). 610 $aInverse limit. 610 $aInverse system. 610 $aK-theory. 610 $aLeray spectral sequence. 610 $aLie group. 610 $aLocal ring. 610 $aMapping cylinder. 610 $aNatural number. 610 $aNatural transformation. 610 $aNeighbourhood (mathematics). 610 $aNewton polynomial. 610 $aNoetherian ring. 610 $aOpen set. 610 $aOpposite category. 610 $aPointed set. 610 $aPresheaf (category theory). 610 $aReductive group. 610 $aRegular local ring. 610 $aRelative homology. 610 $aResidue field. 610 $aRiemann surface. 610 $aRoot of unity. 610 $aSerre spectral sequence. 610 $aShape theory (mathematics). 610 $aSheaf (mathematics). 610 $aSheaf cohomology. 610 $aSheaf of spectra. 610 $aSimplex. 610 $aSimplicial set. 610 $aSpecial case. 610 $aSpectral sequence. 610 $aSurjective function. 610 $aTheorem. 610 $aTopological K-theory. 610 $aTopological space. 610 $aTopology. 610 $aTubular neighborhood. 610 $aVector bundle. 610 $aWeak equivalence (homotopy theory). 610 $aWeil conjectures. 610 $aWeyl group. 610 $aWitt vector. 610 $aZariski topology. 615 0$aHomotopy theory. 615 0$aSchemes (Algebraic geometry) 615 0$aHomology theory. 676 $a514/.24 700 $aFriedlander$b Eric M., $055737 801 0$bDE-B1597 801 1$bDE-B1597 906 $aBOOK 912 $a9910154744803321 996 $aEtale Homotopy of Simplicial Schemes. (AM-104), Volume 104$92786625 997 $aUNINA LEADER 04398nam 2200529 450 001 9910136805903321 005 20230808192403.0 035 $a(CKB)3710000000631086 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/41045 035 $a(EXLCZ)993710000000631086 100 $a20160411c2016uuuu fy| 0 101 0 $aeng 135 $aurc|#---||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aApplication of genetically encoded indicators to mammalian central nervous system$b[electronic resource] /$fedited by Yoshiyuki Yamada and Katsuhiko Mikoshiba 210 $cFrontiers Media SA$d2016 210 1$a[Place of publication not identified] :$cFrontiers Media SA,$d2016. 215 $a1 online resource (116 pages) $cillustrations; digital file(s) 225 0 $aFrontiers Journal series 225 1 $aFrontiers Research Topics,$x1664-8714 300 $a"Published in: Frontiers in molecular neuroscience" --front cover. 311 $a2-88919-804-9 320 $aIncludes bibliographical references. 327 $aEditorial: application of genetically encoded indicators to mammalian central nervous system --Monitoring activity in neural circuits with genetically encoded indicators --Putting a finishing touch on GECIs --Genetically encoded Ca²? indicators; expanded affinity range, color hue and compatibility with optogenetics --Investigating neuronal function with optically controllable proteins --Exploration of genetically encoded voltage indicators based on a chimeric voltage sensing domain --Engineering a genetically-encoded SHG chromophore by electrostatic targeting to the membrane --Imaging activity in astrocytes and neurones with genetically encoded calcium indicators following in utero electroporation --Intracellular calcium dynamics in cortical microglia responding to focal laser injury in the PC::G5-tdT reporter mouse --Wide-field Ca²? imaging reveals visually evoked activity in the retrosplenial area --Habituation of glomerular responses in the olfactory bulb following prolonged odor stimulation reflects reduced peripheral input. 330 3 $aGenetically encoded indicators emerged as promising tools for cell type-specific and chronic recording of neuronal population activity. Since publication of the first prototypical genetically encoded Ca2+ indicators (Cameleons) in 1997, we have witnessed remarkable evolution of the field, with rapid improvement of indicator performance as well as expanded application to many model organisms in the neuroscience community. Challenges still remain, however, concerning the mammalian central nervous system: limited sensitivity of indicators to subtle changes in activity, slow signal kinetics, cytotoxicity after a long-term and high-level expression of indicators, and variable performance across cell types. In addition to improvement of the indicators per se, development of strategies that allow combined use of the indicators and optogenetic tools is also desired. In this Research Topic, we recruited top researchers in the field and their young colleagues to present their cutting-edge research as well as insightful opinions on the following subtopics:1) Latest breakthroughs on development of genetically encoded indicators2) Novel scientific findings obtained with genetically encoded indicators3) Wishlist for the next-generation genetically encoded indicators4) Guideline for selecting an appropriate indicator5) Optimal methodology for indicator delivery to mammalian CNS. 410 0$aFrontiers Research Topics,$x1664-8714 606 $aNeurosciences 606 $aNeurosciences$xResearch 606 $aNeuropsychiatry$xResearch 610 $ain vivo imaging 610 $aGenetically encoded calcium indicators (GECIs) 610 $agenetically encoded voltage sensor 610 $aFluorescent protein sensors 610 $agenetically encoded sensors 615 0$aNeurosciences. 615 0$aNeurosciences$xResearch. 615 0$aNeuropsychiatry$xResearch. 700 $aYoshiyuki Yamada$4auth$01376542 702 $aYamada$b Yoshiyuki 702 $aMikoshiba$b Katsuhiko$f1945- 801 2$bUkMaJRU 906 $aBOOK 912 $a9910136805903321 996 $aApplication of genetically encoded indicators to mammalian central nervous system$93412437 997 $aUNINA LEADER 01511nam0 22003491i 450 001 UON00018946 005 20231205102008.733 100 $a20020107d1956 |0itac50 ba 101 $aeng 102 $aGB 105 $a|||| 1|||| 200 1 $aˆThe ‰teachings of the Magi$eA compendium of zoroastrian beliefs$fby R.C. 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