LEADER 00923nam0 22002411i 450 001 UON00007762 005 20231205101919.44 100 $a20020107d1929 |0itac50 ba 101 $aeng 102 $aUS 105 $a|||| ||||| 200 1 $aSlaves of the Gods$fKatherine Mayo 210 $aNew York$cHarcourt, Brace and Company$d1929 278 p. ; 18 cm 620 $aUS$dNew York$3UONL000050 686 $aSI VI N$cSUBCONT. 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The study of membrane protein structures not only provides a basic understanding of life at the molecular level but also helps in the rational and targeted design of new drugs with reduced side effects.  Today, about 60% of the commercially available drugs target membrane proteins and it is estimated that nearly 30% of proteins encoded in the human genome are membrane proteins. In recent years much effort has been put towards innovative developments to overcome the numerous obstacles associated with the structure determination of membrane proteins. This book reviews a variety of recent techniques that are essential to any modern researcher in the field of membrane protein structural biology. The topics that are discussed are not commonly found in textbooks. The scope of this book includes: Expression screening using fluorescent proteins The use of detergents in membrane protein research The use of NMR Synchrotron developments in membrane protein structural biology Visualisation and X-ray data collection of microcrystals X-ray diffraction data analysis from multiple crystals Serial millisecond crystallography Serial femtosecond crystallography Membrane protein structures in drug discovery The information provided in this book should be of interest to anyone working in the area of structural biology. Students will find carefully prepared overviews of basic ideas and advanced protein scientists will find the level of detail required to apply the material directly to their day to day work. 410 0$aAdvances in Experimental Medicine and Biology,$x0065-2598 ;$v922 606 $aProteins 606 $aProtein Science$3https://scigraph.springernature.com/ontologies/product-market-codes/L14040 606 $aProtein Structure$3https://scigraph.springernature.com/ontologies/product-market-codes/L14050 615 0$aProteins. 615 14$aProtein Science. 615 24$aProtein Structure. 676 $a572.696 702 $aMoraes$b Isabel$4edt$4http://id.loc.gov/vocabulary/relators/edt 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910253903303321 996 $aNext Generation in Membrane Protein Structure Determination$94311939 997 $aUNINA