LEADER 05441nam 22006734a 450 001 9911092850903321 005 20200520144314.0 010 $a1-280-18546-5 010 $a9786610185467 010 $a0-309-57001-8 035 $a(CKB)111069351120062 035 $a(EBL)3377371 035 $a(SSID)ssj0000124881 035 $a(PQKBManifestationID)11141399 035 $a(PQKBTitleCode)TC0000124881 035 $a(PQKBWorkID)10047462 035 $a(PQKB)11635515 035 $a(MiAaPQ)EBC3377371 035 $a(Au-PeEL)EBL3377371 035 $a(CaPaEBR)ebr10071398 035 $a(CaONFJC)MIL18546 035 $a(OCoLC)923269802 035 $a(EXLCZ)99111069351120062 100 $a20020116d2001 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aColloquium on Virulence and Defense in Host-Pathogen Interactions $eCommon Features Between Plants and Animals /$f[edited by Noel T. Keen ... et al.] 205 $a1st ed. 210 $aWashington, D.C. $cNational Academy of Sciences$d2001 215 $a1 online resource (124 pages) $cillustrations 225 1 $aNational Academy of Sciences colloquium series 300 $a"Reprinted from the Proceedings of the National Academy of Sciences of America, volume 97, pp. 8752-8862, August 1, 2000, and includes articles from the National Academy of Sciences' Colloquim on Virulence and Defense in Host-Pathogen Interactions: Common Features Between Plants and Animals, held at the Arnold and Mabel Beckman Center in Irvine, California, December 9-11, 1999"--P. [2] of cover. 311 0 $a0-309-07080-5 320 $aIncludes bibliographical references. 327 $a""COLLOQUIUM ON Virulence and Defense in Hosta???Pathogen Interactions: Common Features Between Plants and Animals""; ""Contents""; ""Introduction""; ""Colloquium Striking a balance: Modulation of the actin cytoskeleton by Salmonella""; ""THE CENTISOME 63 TYPE III SECRETION SYSTEM: SALMONELLA'S KEY TO ENTER INTO HOST CELLS""; ""REVVING UP RHO GTPASES: SIGNALING FOR ENTRY AND BEYOND""; ""DOWNSTREAM SIGNALING: EFFECTORS OF CDC42 AND RAC-1 FUNCTION""; ""FINE-TUNING THE ACTIN CYTOSKELETON REARRANGEMENTS: THE ROLE OF THE ACTIN-BINDING PROTEIN SIPA"" 327 $a""PUTTING ON THE BRAKES: A LESSON ON SELF-RESTRAINT"" ""LESSONS LEARNED FROM SALMONELLA""; ""Colloquium Structure and function of pectic enzymes: Virulence factors of plant pathogens""; ""DIFFERENCE IN OUTER BARRIERS OF PLANT AND MAMMALIAN CELLS""; ""DEGRADATIVE ENZYMES OF PLANT CELL WALL COMPONENTS""; ""THREE-DIMENSIONAL STRUCTURES OF PLANT CELL WALL DEGRADATIVE ENZYMES""; ""STRUCTURAL APPROACHES TO THE ELUCIDATION OF THE ENZYMATIC MECHANISM OF PELC""; ""STRUCTURE OF THE PELC R218K-(CA2+)4-PENTAGALPA COMPLEX""; ""SIGNIFICANCE OF MULTIPLE ISOZYMES FOR PATHOGENESIS"" 327 $a""MODEL OF THE PLB-MGALPA4 COMPLEX"" ""CONCLUSIONS""; ""METHODS""; ""Colloquium Pseudomonas syringae Hrp type III secretion system and effector proteins""; ""HOPPSYA, PHIR11, AND THE MINIMUM GENETIC UNIT FOR BACTERIAL ELICITATION OF THE HYPERSENSITIVE RESPONSE""; ""FUNCTIONS OF HRP SYSTEM COMPONENTS""; ""THE TRIPARTITE MOSAIC STRUCTURE OF THE P. SYRINGAE HRP PAI""; ""AN EEL MAKES A SMALL CONTRIBUTION TO PARASITIC FITNESS""; ""THE CEL IS IMPORTANT FOR PATHOGENICITY""; ""HRPK AND CEL ORF1""; ""EFFECTOR PROTEIN SECRETION AND A UNIVERSAL TYPE III TARGETING SIGNAL""; ""CONCLUSIONS"" 327 $a""Colloquium Molecular and cell biology aspects of plague"" ""A DEVICE TO INJECT BACTERIAL PROTEINS ACROSS EUKARYOTIC CELL MEMBRANES""; ""EFFECTOR YOPS AND HOST RESPONSE""; ""Colloquium A framework for interpreting the leucine-rich repeats of the Listeria internalins ""; ""INTERNALIN FAMILY""; ""INTERNALIN LRR""; ""LRR FLANKING SEQUENCES""; ""LRR PATTERN: STRUCTURAL RESIDUES""; ""LRR PATTERN: FUNCTIONAL RESIDUES""; ""Colloquium Acyl-homoserine lactone quorum sensing in Gram-negative bacteria: A signaling mechanism involved in associations ""; ""OVERVIEW OF ACYL-HSL QUORUM SENSING"" 327 $a""QUORUM SENSING IN P. AERUGINOSA""""REGULATION OF VIRULENCE BY QUORUM SENSING IN P. AERUGINOSA""; ""BIOFILMS AND QUORUM SENSING""; ""FUTURE CHALLENGES""; ""Colloquium Phenotypic variation and intracellular parasitism by Histoplasma capsulatum""; ""MODULATION OF I??-(1,3)-GLUCAN IN THE CELL WALL""; ""CALCIUM AND INTRACELLULAR PARASITISM""; ""REGULATION OF CBP""; ""HISTOPLASMA AS A MODEL SYSTEM""; ""Colloquium Exploitation of host cells by enteropathogenic Escherichia coli""; ""CLINICAL SYMPTOMS AND PATHOLOGY""; ""THE LOCUS OF ENTEROCYTE EFFACEMENT""; "LOCALIZED EPEC ADHERENCE TO EPITHELIAL CELLS"" 410 0$aNational Academy of Sciences colloquium series. 606 $aVirulence (Microbiology)$vCongresses 606 $aHost-parasite relationships$vCongresses 606 $aImmune response$xMolecular aspects$vCongresses 615 0$aVirulence (Microbiology) 615 0$aHost-parasite relationships 615 0$aImmune response$xMolecular aspects 676 $a571.9/6 701 $aKeen$b Noel T.$f1940-$0293405 712 02$aNational Academy of Sciences (U.S.) 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9911092850903321 996 $aColloquium on Virulence and Defense in Host-Pathogen Interactions$94740440 997 $aUNINA LEADER 03078nam 2200625 a 450 001 9911141833403321 005 20251017110056.0 010 $a0-309-22067-X 010 $a1-280-12334-6 010 $a9786613527202 010 $a0-309-22065-3 035 $a(CKB)2670000000176340 035 $a(OCoLC)794491570 035 $a(CaPaEBR)ebrary10554791 035 $a(SSID)ssj0000645747 035 $a(PQKBManifestationID)11380818 035 $a(PQKBTitleCode)TC0000645747 035 $a(PQKBWorkID)10683766 035 $a(PQKB)10169540 035 $a(MiAaPQ)EBC3378946 035 $a(Au-PeEL)EBL3378946 035 $a(CaPaEBR)ebr10554791 035 $a(CaONFJC)MIL352720 035 $a(OCoLC)785373830 035 $a(DNLM)1583262 035 $a(EXLCZ)992670000000176340 100 $a20120509d2012 uy 0 101 0 $aeng 135 $aurcn||||||||| 181 $ctxt 182 $cc 183 $acr 200 10$aFacilitating collaborations to develop combination investigational cancer therapies $eworkshop summary /$fMargie Patlak, Erin Balogh, and Sharyl J. Nass, rapporteurs ; Institute of Medicine of the National Academies 205 $a1st ed. 210 $aWashington, D.C. $cNational Academies Press$d2012 215 $a1 online resource (117 p.) 300 $a"National Cancer Policy Forum, Board on Health Care Services." 311 08$a0-309-22064-5 320 $aIncludes bibliographical references. 327 $aIntroduction -- Why Combinations and Collaborations Are Necessary -- Scientific Challenges in Developing Investigational Combination Therapies -- Overcoming Cultural Challenges to Collaborations Legal Issues in Collaborations -- Financial Challenges -- Regulatory Issues -- Codevelopment of Therapies for HIV as a Model -- Examples of Collaborations Relevant to Cancer -- Wrapping Up -- Appendix A: Examples of Collaborations -- Appendix B: Workshop Agenda -- References -- Acronyms. 330 $a"Advances in biomedical research have increased our understanding of the complex nature of disease and the interaction of multiple molecular pathways involved in cancer. Combining investigational products early in their development is thought to be a promising strategy for identifying effective therapies. The IOM's National Cancer Policy Forum held a workshop to discuss challenges and identify potential solutions to improve collaboration and advance the development of combination investigational cancer therapies."--Publisher's description. 606 $aCancer$xTreatment 615 0$aCancer$xTreatment. 701 $aPatlak$b Margie$01607028 701 $aBalogh$b Erin$01089066 701 $aNass$b Sharyl J$0857626 712 02$aNational Cancer Policy Forum (U.S.) 712 02$aInstitute of Medicine (U.S.).$bBoard on Health Care Services. 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9911141833403321 996 $aFacilitating collaborations to develop combination investigational cancer therapies$94874292 997 $aUNINA