LEADER 03060nam 2200409z- 450 001 9911115442703321 005 20210212 035 $a(CKB)4920000000094270 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/60439 035 $a(oapen)doab60439 035 $a(EXLCZ)994920000000094270 100 $a20202102d2017 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aSystems Biology and the Challenge of Deciphering the Metabolic Mechanisms Underlying Cancer 210 $cFrontiers Media SA$d2017 215 $a1 online resource (142 p.) 225 1 $aFrontiers Research Topics 311 08$a2-88945-333-2 330 $aSince the discovery of the Warburg effect in the 1920s cancer has been tightly associated with the genetic and metabolic state of the cell. One of the hallmarks of cancer is the alteration of the cellular metabolism in order to promote proliferation and undermine cellular defense mechanisms such as apoptosis or detection by the immune system. However, the strategies by which this is achieved in different cancers and sometimes even in different patients of the same cancer is very heterogeneous, which hinders the design of general treatment options.Recently, there has been an ongoing effort to study this phenomenon on a genomic scale in order to understand the causality underlying the disease. Hence, current "omics" technologies have contributed to identify and monitor different biological pieces at different biological levels, such as genes, proteins or metabolites. These technological capacities have provided us with vast amounts of clinical data where a single patient may often give rise to various tissue samples, each of them being characterized in detail by genomescale data on the sequence, expression, proteome and metabolome level. Data with such detail poses the imminent problem of extracting meaningful interpretations and translating them into specific treatment options. To this purpose, Systems Biology provides a set of promising computational tools in order to decipher the mechanisms driving a healthy cell's metabolism into a cancerous one. However, this enterprise requires bridging the gap between large data resources, mathematical analysis and modeling specifically designed to work with the available data. This is by no means trivial and requires high levels of communication and adaptation between the experimental and theoretical side of research. 606 $aPhysiology$2bicssc 610 $aCancer 610 $aComputational Biology 610 $aMetabolic alterations 610 $aMetabolism 610 $aModeling 610 $aSystems Biology 615 7$aPhysiology 700 $aChristian Diener$4auth$02007992 702 $aOsbaldo Resendis-Antonio$4auth 906 $aBOOK 912 $a9911115442703321 996 $aSystems Biology and the Challenge of Deciphering the Metabolic Mechanisms Underlying Cancer$94794960 997 $aUNINA LEADER 02403nam 2200613Ia 450 001 9911131610203321 005 20260415135807.0 010 $a979-82-16-21448-9 010 $a1-283-87597-7 010 $a1-4616-6402-0 035 $a(CKB)2550000000709944 035 $a(EBL)1037548 035 $a(SSID)ssj0000810343 035 $a(PQKBManifestationID)12349444 035 $a(PQKBTitleCode)TC0000810343 035 $a(PQKBWorkID)10833385 035 $a(PQKB)11544640 035 $a(Au-PeEL)EBL1037548 035 $a(CaPaEBR)ebr10639612 035 $a(CaONFJC)MIL418847 035 $a(OCoLC)854520048 035 $a(MiAaPQ)EBC1037548 035 $a(EXLCZ)992550000000709944 100 $a20100513e20102009 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 14$aThe A to Z of animation and cartoons /$fNichola Dobson 205 $a1st ed. 210 $aLanham, Md. $cScarecrow Press$d2010, c2009 215 $a1 online resource (434 p.) 225 1 $aThe A to Z guide series ;$vno. 194 300 $aDescription based upon print version of record. 311 08$a0-8108-7623-X 320 $aIncludes bibliographical references. 327 $aCover; Title Page; Copyright Page; Table of Contents; Editor's Foreword; Preface; Acknowledgments; Acronyms and Abbreviations; Chronology; Introduction; The Dictionary; Bibliography; About the Authors 330 $aThe A to Z of Animation and Cartoons is an introduction to all aspects of animation history and its development as a technology and industry beyond the familiar cartoons from the Disney and Warner Bros. Studios. This is done through a chronology, an introductory essay, photos, a bibliography, and over 200 cross-referenced dictionary entries on animators, directors, studios, techniques, films, and some of the best-known characters. 410 0$aA to Z guides ;$v194. 517 3 $aAnimation and cartoons 606 $aAnimated films$vDictionaries 606 $aMotion picture industry$vDictionaries 615 0$aAnimated films 615 0$aMotion picture industry 676 $a791.4334 700 $aDobson$b Nichola$f1976-$0849925 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9911131610203321 996 $aThe A to Z of animation and cartoons$94839990 997 $aUNINA