LEADER 01916nam 2200409z- 450 001 9911115529003321 005 20210211 035 $a(CKB)4100000002484695 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/42712 035 $a(oapen)doab42712 035 $a(EXLCZ)994100000002484695 100 $a20202102d2017 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aCardiac Remodeling: New Insights in Physiological and Pathological Adaptations 210 $cFrontiers Media SA$d2017 215 $a1 online resource (117 p.) 225 1 $aFrontiers Research Topics 311 08$a2-88945-331-6 330 $aThe effective management of Cardiac remodeling(CR), remains a major challenge. Heart failure remains the leading cause of death in industrialized countries. Yet, despite the enormity of the problem, effective therapeutic interventions remain elusive. In fact, several initially promising agents were found to decrease mortality in patients recovering from myocardial infarction. Cardiac remodeling is defined as molecular and interstitial changes, manifested clinically by changes in size, mass , geometry and function of the heart in response to certain aggression. Initially, ventricular remodeling aims to maintain stable cardiac function in situations of aggression. 517 $aCardiac Remodeling 606 $aPhysiology$2bicssc 610 $aCardiac Remodeling 610 $aFibrosis 610 $aHeart Failure 610 $aInflammation 610 $aPhysiology 615 7$aPhysiology 700 $aLeonardo Roever$4auth$02006531 702 $aAntonio C. Palandri Chagas$4auth 906 $aBOOK 912 $a9911115529003321 996 $aCardiac Remodeling: New Insights in Physiological and Pathological Adaptations$94792929 997 $aUNINA