LEADER 02448nam  2200397z- 450 
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035   $a(CKB)4920000000094120
035   $a(oapen)https://directory.doabooks.org/handle/20.500.12854/42239
035   $a(oapen)doab42239
035   $a(EXLCZ)994920000000094120
100   $a20202102d2018      |y         0
101 0 $aeng
135   $aurmn|---annan
181   $ctxt$2rdacontent
182   $cc$2rdamedia
183   $acr$2rdacarrier
200 00$aBiology of Brain Disorders
210   $cFrontiers Media SA$d2018
215   $a1 online resource (586 p.)
225 1 $aFrontiers Research Topics
311 08$a2-88945-380-4 
330   $aBrain disorders, including neurological and neuropsychiatric conditions, represent a challenge for public health systems and society at large. The limited knowledge of their biology hampers the development of diagnostic tools and effective therapeutics. A clear understanding of the mechanisms that underlie the onset and progression of brain disorders is required in order to identify new avenues for therapeutic intervention.Overlapping genetic risk factors across different brain disorders suggest common linkages and pathophysiological mechanisms that underlie brain disorders. Methodological and technological advances are leading to new insights that go beyond traditional hypotheses. Taking account of underlying molecular, cellular and systems biology underlying brain function will play an important role in the classification of brain disorders in future.In this Research Topic, the latest advances in our understanding of biological mechanisms across different brain disorders are presented. The areas covered include developments in neurogenetics, epigenetics, plasticity, glial cell biology, neuroimmune interactions and new technologies associated with the study of brain function. Examples of how understanding of biological mechanisms are translating into research strategies that aim to advance diagnoses and treatment of brain disorders are discussed.
606   $aMedicine$2bicssc
610   $aAgeing
610   $aBrain
610   $aneurodegeneration
610   $aNeurons
610   $aneuropsychiatric
615  7$aMedicine
700   $aAndrew Harkin$4auth$02009737
702   $aDaniela Tropea$4auth
906   $aBOOK
912   $a9911115474603321
996   $aBiology of Brain Disorders$94797282
997   $aUNINA