LEADER 03945nam 2200613Ia 450 001 996218390403316 005 20230421044212.0 010 $a1-281-75888-4 010 $a9786611758882 010 $a3-527-61682-9 010 $a3-527-61683-7 035 $a(CKB)1000000000540643 035 $a(EBL)482141 035 $a(SSID)ssj0000230975 035 $a(PQKBManifestationID)11173865 035 $a(PQKBTitleCode)TC0000230975 035 $a(PQKBWorkID)10197380 035 $a(PQKB)10763076 035 $a(MiAaPQ)EBC482141 035 $a(OCoLC)214281974 035 $a(EXLCZ)991000000000540643 100 $a19940418d1993 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aQSAR : Hansch analysis and related approaches$b[electronic resource] /$fby Hugo Kubinyi 210 $aWeinheim ;$aNew York $cVCH$dc1993 215 $a1 online resource (254 p.) 225 1 $aMethods and principles in medicinal chemistry ;$vv. 1 300 $aDescription based upon print version of record. 311 $a3-527-30035-X 320 $aIncludes bibliographical references (p. [183]-210) and index. 327 $aQSAR: Hansch Analysis and Related Approaches; Content; 1. Introduction; 1.1. History and Development of QSAR; 1.2. Drug-Receptor Interactions; 2. Biological Data. The Additivity of Group Contributions; 3. Parameters; 3.1. Lipophilicity Parameters; 3.2. The Measurement of Partition Coefficients and Related Lipophilicity Parameters; 3.3. Lipophilicity Contributions and the Calculation of Partition Coefficients; 3.4. Polarizability Parameters; 3.5. Electronic Parameters; 3.6. Steric Parameters; 3.7. Other Parameters; 3.8. Indicator Variables; 4. Quantitative Models 327 $a4.1. The Extrathermodynamic Approach (Hansch Analysis)4.2. The Additivity Model (Free Wilson Analysis); 4.3. The Relationships between Hansch and Free Wilson Analysis (The Mixed Approach); 4.4. Nonlinear Relationships; 4.5. Dissociation and Ionization of Acids and Bases; 4.6. Other QSAR Approaches; 5. Statistical Methods; 5.1. Regression Analysis; 5.2. The Significance and Validity of QSAR Regression Equations; 5.3. Partial Least Squares (PLS) Analysis and Other Multivariate Statistical Methods; 6. Design of Test Series in QSAR; 7. Applications of Hansch Analysis; 7.1. Enzyme Inhibition 327 $a7.2. Other in vitro Data7.3. Pharmacokinetic Data; 7.4. Other Biological Data; 7.5. Activity-Activity Relationships; 8. Applications of Free Wilson Analysis and Related Models; 9. 3D QSAR Approaches; 9.1. Stereochemistry and Drug Action; 9.2. Active Site Interaction Models; 9.3. Comparative Molecular Field Analysis (CoMFA); 9.4. Molecular Similarity QSAR Analyses; 10. Summary and Conclusions; References; Index 330 $aFinding the new remedy for a certain disease: an inspired goal. QSAR, an invaluable tool in drug design, aids scientists to attain this aim.This book is a long-awaited comprehensive text to QSAR and related approaches. It provides a practice-oriented introduction to the theory, methods and analyses for QSAR relationships, including modelling-based and 3D approaches.Hugo Kubinyi is a leading expert in QSAR. Readers will benefit from the author's 20 years of practical experience, from his careful calculations and recalculations of thousands of QSAR equations. Among the topics cov 410 0$aMethods and principles in medicinal chemistry ;$vv. 1. 606 $aQSAR (Biochemistry) 606 $aPharmaceutical chemistry 615 0$aQSAR (Biochemistry) 615 0$aPharmaceutical chemistry. 676 $a572.072 676 $a615 676 $a615.1901 700 $aKubinyi$b Hugo$096070 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a996218390403316 996 $aQSAR : Hansch analysis and related approaches$92137944 997 $aUNISA LEADER 03130nam 22008053u 450 001 9910966078103321 005 20200520144314.0 010 $a0-19-772998-3 010 $a1-280-52704-8 010 $a0-19-535906-2 010 $a1-4294-0038-2 024 7 $a10.1093/oso/9780195085310.001.0001 035 $a(CKB)1000000000410388 035 $a(EBL)271034 035 $a(OCoLC)191924623 035 $a(SSID)ssj0000108029 035 $a(PQKBManifestationID)11135227 035 $a(PQKBTitleCode)TC0000108029 035 $a(PQKBWorkID)10013703 035 $a(PQKB)11590312 035 $a(Au-PeEL)EBL271034 035 $a(CaPaEBR)ebr10142213 035 $a(CaONFJC)MIL52704 035 $a(OCoLC)936849445 035 $a(MiAaPQ)EBC271034 035 $a(OCoLC)1406788265 035 $a(StDuBDS)9780197729984 035 $a(OCoLC)29877007 035 $a(FINmELB)ELB168450 035 $a(EXLCZ)991000000000410388 100 $a19950814e20231995 |y | 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aAutonomy and intervention $eparentalism in the caring life /$fJohn Kultgen 205 $a1st ed. 210 1$aNew York ;$cOxford University Press,$d2023. 215 $a1 online resource (xiii, 262 pages) 225 1 $aOxford scholarship online 300 $aPreviously issued in print: 1995. 311 0 $a0-19-508531-0 320 $aIncludes bibliographical references (p. 253-256) and index. 327 $aContents; 1. The Life of Care; 2. Care and Moral Intuition; 3. Care and Morality; 4. The Parental Analogy; 5. Parentalism Defined; 6. The Evaluation of Parentalism; 7. The Anatomy of Intervention; 8. The Value of Autonomy; 9. The Role of Consent; 10. Varieties of Antiparentalism; 11. VanDeVeer's Consent-Based Antiparentalism; 12. The State as Parentalist; 13. Feinberg's Antiparentalism; 14. Professional Parentalism; 15. Conclusion; Appendix: Critical Review of the Literature; Notes; Bibliography; Index 330 8 $aThis philosophical treatise explores the place of paternalism in caring for others. It provides guidelines for balancing respect for the recipients' autonomy with the good that can be provided by intervening in their lives. 410 0$aOxford scholarship online. 606 $aRespect for persons 606 $aCaring 606 $aPaternalism$xMoral and ethical aspects 606 $aAutonomy (Philosophy) 606 $aCommunity life 606 $aInvoluntary treatment$xMoral and ethical aspects 615 0$aRespect for persons. 615 0$aCaring. 615 0$aPaternalism$xMoral and ethical aspects. 615 0$aAutonomy (Philosophy) 615 0$aCommunity life. 615 0$aInvoluntary treatment$xMoral and ethical aspects. 676 $a171.1 676 $a177/.7 700 $aKultgen$b John H.$0902716 801 0$bUkCU 801 2$bUk 801 2$bStDuBDSZ 801 2$bStDuBDSZ 906 $aBOOK 912 $a9910966078103321 996 $aAutonomy and intervention$94525282 997 $aUNINA LEADER 00775nas 2200289zu 450 001 9911056225403321 005 20260218111517.0 011 $a2982-1975 035 $a(CKB)45004200200041 035 $a(DE-599)ZDB3234012-6 035 $a(DE-599)3234012-6 035 $a(EXLCZ)9945004200200041 100 $a20260124cuuuuuuuu || | 101 0 $aeng 135 $aur||||||||||| 200 00$aJournal of Medicinal Natural Products 210 $aAustralia: $cScilight Press Pty Ltd 610 0$anatural products 610 0$abioactivities 610 0$abiochemistry 610 0$apharmacology 610 0$asynthesis 610 0$amedicine 906 $aJOURNAL 912 $a9911056225403321 996 $aJournal of Medicinal Natural Products$94530427 997 $aUNINA