LEADER 04796nam 22005895 450 001 9911049223503321 005 20260102120739.0 010 $a3-032-07686-2 024 7 $a10.1007/978-3-032-07686-1 035 $a(CKB)44770129300041 035 $a(MiAaPQ)EBC32470104 035 $a(Au-PeEL)EBL32470104 035 $a(DE-He213)978-3-032-07686-1 035 $a(EXLCZ)9944770129300041 100 $a20260102d2026 u| 0 101 0 $aeng 135 $aur||||||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aCellular and Molecular Mechanisms of Chronic Rejection in Organ Transplantation /$fedited by Malgorzata Kloc, Rafik Mark Ghobrial 205 $a1st ed. 2026. 210 1$aCham :$cSpringer Nature Switzerland :$cImprint: Springer,$d2026. 215 $a1 online resource (385 pages) 225 1 $aResults and Problems in Cell Differentiation,$x1861-0412 ;$v77 311 08$a3-032-07685-4 327 $aPart I. Overview of Cellular and Molecular Effectors in Chronic Rejection and the Computational Approaches -- Chapter 1. Cellular and Molecular Aspects of Chronic Rejection -- Chapter 2. Cellular and Molecular Aspects of Chronic Rejection -- Chapter 3. Exploring Chronic Rejection in Organ Transplantation through Computational Modeling -- Part II. Immune Cells, Non-Immune Cells, and Extracellular Molecules in Chronic Rejection -- Chapter 4. The Role of the Endothelium as a Key Regulator of Chronic Transplant Rejection -- Chapter 5. Pathogenesis of Chronic Rejection: Graft Endothelial Cell Trans-presentation of IL-15 Connects Alloantibody- and Cell-Mediated Steps in Allograft Vasculopathy -- Chapter 6. Macrophage Actin Cytoskeleton in Chronic Rejection -- Chapter 7. Donor-Derived Cell-Free DNA in Acute and Chronic Rejection of Solid Allograft Transplantation. Part III. Shared and Organ-Specific Features of Chronic Rejection and Therapeutic Approaches -- Chapter 8. Vascular Remodeling in Chronic Rejection: Insights into Transplant Vasculopathy Across Solid Organ Allografts -- Chapter 9. The Myeloid-T Lymphocyte Axis in Chronic Lung Allograft Rejection: Emerging Insights into the Immune Circuitry Driving Fibrosis -- Chapter 10. Chronic Rejection in Facial Vascularized Composite Allotransplantation (fVCA) -- Chapter 11. Evolving Therapeutic Approaches for Treatment of Antibody Mediated Rejection in Renal Allograft Recipients -- Chapter 12. Chronic Liver Allograft Rejection: Histopathological Insights and Future Directions. 330 $aDespite improvements in antirejection therapies, solid organ transplantation is hampered by chronic rejection, with around 70% of transplants being rejected within 10 years post-transplantation. Given the growing number of transplant candidates and the shortage of organ donors, finding a cure for chronic rejection is a priority in transplantation. Although chronic rejection studies have increased our knowledge of the subject over the years, the cellular and molecular processes involved in chronic rejection are still not fully understood. This volume covers the molecular and cellular aspects of the chronic rejection of both solid and composite allografts. It is divided into three parts: Part I provides a comprehensive overview and mechanistic understanding of the cellular and molecular pathways underlying chronic rejection, as well as their potential in identifying novel biomarkers and developing targeted anti-chronic rejection strategies. Part II focuses on immune cells, non-immune cells, and extracellular molecules in the context of chronic rejection. Part III concentrates on shared and organ-specific (liver, face, kidney, lung) features as well as the latest therapeutic approaches in chronic rejection. The book provides a comprehensive overview of the mechanisms and challenges involved, with the aim of inspiring the development of new therapies for chronic rejection. 410 0$aResults and Problems in Cell Differentiation,$x1861-0412 ;$v77 606 $aTransplantation immunology 606 $aCytology 606 $aMolecular biology 606 $aTransplant immunology 606 $aCell Biology 606 $aMolecular Biology 615 0$aTransplantation immunology. 615 0$aCytology. 615 0$aMolecular biology. 615 14$aTransplant immunology. 615 24$aCell Biology. 615 24$aMolecular Biology. 676 $a571.96 676 $a617.95 700 $aKloc$b Malgorzata$01453555 701 $aGhobrial$b Rafik Mark$01886299 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9911049223503321 996 $aCellular and Molecular Mechanisms of Chronic Rejection in Organ Transplantation$94521785 997 $aUNINA