LEADER 04615nam 22007335 450 001 9911049218703321 005 20260102122735.0 010 $a3-032-10024-0 024 7 $a10.1007/978-3-032-10024-5 035 $a(CKB)44770026200041 035 $a(MiAaPQ)EBC32471145 035 $a(Au-PeEL)EBL32471145 035 $a(DE-He213)978-3-032-10024-5 035 $a(EXLCZ)9944770026200041 100 $a20260102d2026 u| 0 101 0 $aeng 135 $aur||||||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aOrganoids for Preclinical Disease Modeling and Personalized Medicine /$fedited by Ozge Sezin Somuncu 205 $a1st ed. 2026. 210 1$aCham :$cSpringer Nature Switzerland :$cImprint: Springer,$d2026. 215 $a1 online resource (229 pages) 225 1 $aStem Cell Biology and Regenerative Medicine,$x2196-8993 ;$v78 311 08$a3-032-10023-2 327 $aEmerging roles of organoids in cancer research -- University of Greenwich -- Preclinical organoid models for modeling cancer -- Dana Farber Cancer Institute -- Prognostication of DNA repair inhibitor response in cancer organoids -- Ramya Ravindranathan -- Unraveling radiation response Insights from organoid systems -- Zeinaf Muradova -- Bladder organoids for healthy and diseased tissue modeling -- Dilara Akbulut -- Organoids to investigate immune functions immunological diseases and therapy -- Alexander Cicala -- Lymphoma organoid models for evaluating and targeting tumor immune microenvironment -- Sahin Lacin -- The use of organoids for modeling bone tumors and testing drugs -- Doruk Somuncu -- Lung organoids in disease modeling and treatment -- Organoid technology for brain disease modeling -- Deniz Altunsu Kurt -- Investigating pediatric diseases with organoid systems -- Fulden Aycan -- Engineering transplantable organoids for children with pediatric disorder -- Tansu Salman -- Organoid technology in cardiology for disease modeling and treatment -- Irem Turkmen -- Gastrointestinal organoids from pluripotent stem cells Jose Guillermo Sanchez Arriola Cincinnati Children Hospital Medical Center -- Brain organoids for unraveling human brain development and evolution -- Organoids for modeling skin hair pigmentation -- Proteomics applications on organoids to improve preclinical research. 330 $aOrganoid technologies are preclinical models in which drug responses or radiotherapies are determined very closely to patient response. While until the recent past there were no three-dimensional systems in which the entire cellular content of an organ could be reflected, we can now create the physiological and structural features of an organ in vitro and model a disease effectively. As these diseases may be developmental defects, chronic diseases can also be investigated in detail at the gene and protein level with these systems. In terms of developmental biology, thanks to the use of organoids, it is possible to learn the physiological internal dynamics of organs and to model diseases other than cancer. Chapters include introductions to their respective topics, recent advancements and how future applications can be implemented to organoid models. Organoids for Preclinical Disease Modeling and Personalized Medicine serves as an aid to researchers working in this vital area of research. 410 0$aStem Cell Biology and Regenerative Medicine,$x2196-8993 ;$v78 606 $aStem cells 606 $aRegenerative medicine 606 $aDiseases$xAnimal models 606 $aImmunology 606 $aNeurosciences 606 $aCancer 606 $aStem Cell Biology 606 $aRegenerative Medicine and Tissue Engineering 606 $aDisease Models 606 $aImmunology 606 $aNeuroscience 606 $aCancer Biology 615 0$aStem cells. 615 0$aRegenerative medicine. 615 0$aDiseases$xAnimal models. 615 0$aImmunology. 615 0$aNeurosciences. 615 0$aCancer. 615 14$aStem Cell Biology. 615 24$aRegenerative Medicine and Tissue Engineering. 615 24$aDisease Models. 615 24$aImmunology. 615 24$aNeuroscience. 615 24$aCancer Biology. 676 $a571.6 676 $a616.02774 700 $aSomuncu$b Ozge Sezin$01886401 701 $aSomuncu$01886402 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9911049218703321 996 $aOrganoids for Preclinical Disease Modeling and Personalized Medicine$94521913 997 $aUNINA