LEADER 04326nam 22007575 450 001 9911049173803321 005 20260102122937.0 010 $a981-9544-05-X 024 7 $a10.1007/978-981-95-4405-9 035 $a(CKB)44770015900041 035 $a(MiAaPQ)EBC32470782 035 $a(Au-PeEL)EBL32470782 035 $a(DE-He213)978-981-95-4405-9 035 $a(EXLCZ)9944770015900041 100 $a20260102d2025 u| 0 101 0 $aeng 135 $aur||||||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aMechanobiology of Hydrostatic Pressure $eFrontiers of Biomechanics /$fby Jiro Nagatomi 205 $a1st ed. 2025. 210 1$aSingapore :$cSpringer Nature Singapore :$cImprint: Springer,$d2025. 215 $a1 online resource (147 pages) 225 1 $aFrontiers of Biomechanics,$x2199-8523 ;$v5 311 08$a981-9544-04-1 327 $aPart 1. What is hydrostatic pressure and why is it important for Biomechanics -- Chapter 1.Physics of hydrostatic pressure, continuum mechanics (hydrostatic stress) vs. fluid mechanics (HP as a thermodynamic quantity) -- Chapter 2. Hydrostatic pressure in nature (plant, deep sea biology, bacteria/microorganism) -- Chapter 3. Hydrostatic pressure in mammalian physiology and pathology, various organ systems -- Part 2. In vitro studies of HP mechanobiology -- Chapter 4. HP vs stretch (Bladder, lungs, vascular) -- Chapter 5. HP vs flow (Vascular, Bone) -- Chapter 6. HP vs osmotic (cancer, brain, kidney),- Chapter 7. Static vs dynamic HP (Chondrocyte, IVD) -- Chapter 8. In vitro systems criticism (ocular) -- Part 3. Events and pathways involved in HP Mechanotransduction.-Chapter 9. Intracellular signal transduction -- Chapter 10. Cell volume regulation, aquaporin, membrane, cytoskeleton -- Chapter 11. Membrane bound ion channels and calcium signaling -- Chapter 12. ATP release, purinergic signaling, DAMP, inflammasome -- Chapter 13. ECM synthesis, fibrosis, EMT -- Conclusion. 330 $aThis book compiles and reorganizes previously published research to give readers a clear overview of how living systems respond to hydrostatic pressure?a force present from the deepest oceans to the human body. Although scientists have recognized its importance for decades, many questions remain. By bringing together work from across the field, this volume provides a comprehensive look at both the physical forces involved and the biological processes they influence. The central theme is how cells sense pressure and convert it into biological signals, a process known as Mechan transduction. The book is organized into three sections: the first explains what hydrostatic pressure is and why it matters; the second reviews laboratory studies on pressure and fluid flow in different organ systems; and the third examines studies on pressure and stretching forces. Through this reorganized collection of research, the book offers readers a deeper understanding of the essential role hydrostatic pressure plays in biology and health. 410 0$aFrontiers of Biomechanics,$x2199-8523 ;$v5 606 $aBiomechanics 606 $aBiophysics 606 $aCell interaction 606 $aCytology 606 $aBiomedical engineering 606 $aContinuum mechanics 606 $aMaterials 606 $aFluidics 606 $aBiomechanics 606 $aMechanobiological Cell Signaling 606 $aCell Biology 606 $aBiomedical Engineering and Bioengineering 606 $aContinuum Mechanics 606 $aFluidics 615 0$aBiomechanics. 615 0$aBiophysics. 615 0$aCell interaction. 615 0$aCytology. 615 0$aBiomedical engineering. 615 0$aContinuum mechanics. 615 0$aMaterials. 615 0$aFluidics. 615 14$aBiomechanics. 615 24$aMechanobiological Cell Signaling. 615 24$aCell Biology. 615 24$aBiomedical Engineering and Bioengineering. 615 24$aContinuum Mechanics. 615 24$aFluidics. 676 $a571.43 700 $aNagatomi$b Jiro$01886025 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9911049173803321 996 $aMechanobiology of Hydrostatic Pressure$94521421 997 $aUNINA